Spencer R. Keilich
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View article: Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics
Senescence‐induced changes in CD4 T cell differentiation can be alleviated by treatment with senolytics Open
Aging and senescence impact CD4 T helper cell (Th) subset differentiation during influenza infection. In the lungs of infected aged mice, there were significantly greater percentages of Th cells expressing the transcription factor FoxP3, i…
View article: Early detection of SARS-CoV-2 in circulating immune cells in a mouse model
Early detection of SARS-CoV-2 in circulating immune cells in a mouse model Open
SARS-CoV-2 infects the respiratory tract, lung and then other organs. However, its pathogenesis remains largely unknown. We used RareScope™ Fluorescence Light Sheet Microscopy (FLSM) and fluorescent in situ hybridization of RNA (RNA-FISH) …
View article: Vaccination Improves CD4 T Helper Subset Balance in Aged Mice by Overcoming the Effects of the Senescent Environment
Vaccination Improves CD4 T Helper Subset Balance in Aged Mice by Overcoming the Effects of the Senescent Environment Open
Influenza (flu) infection is a leading cause of morbidity and mortality in older adults. Although vaccination is the best strategy to combat the effects of flu infection, there is a marked decline in vaccine efficacy in older adults. We hy…
View article: Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice
Influenza Infection has Fiber Type-Specific Effects on Cellular and Molecular Skeletal Muscle Function in Aged Mice Open
Skeletal muscle myopathies represent a common non-pulmonary manifestation of influenza infection, leading to reduced physical function and hospitalization in older adults. However, underlying mechanisms remain poorly understood. Our study …
View article: Age‐related factors that affect B cell responses to vaccination in mice and humans
Age‐related factors that affect B cell responses to vaccination in mice and humans Open
Aging significantly changes the ability to respond to vaccinations and infections. In this review, we summarize published results on age‐related changes in response to infection with the influenza virus and on the factors known to increase…
View article: Influenza-induced Muscle Degradation: Mechanisms of Flu-induced Disability with Aging
Influenza-induced Muscle Degradation: Mechanisms of Flu-induced Disability with Aging Open
The goal of this dissertation is to expand our understanding of how influenza (flu) infection negatively impacts skeletal muscle and leads to future disability with aging. We hypothesize that flu infection triggers prolonged inflammation a…
View article: Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment
Assessment of Lymph Node Stromal Cells as an Underlying Factor in Age-Related Immune Impairment Open
Aging negatively impacts immunity, resulting in inefficient responses to vaccinations and infections. Fibroblastic reticular cells (FRCs) are the major stromal cell subset in lymph nodes (LNs) and play an intricate role in the orchestratio…
View article: MECHANISMS OF INFLUENZA-INDUCED DISABILITY WITH AGING
MECHANISMS OF INFLUENZA-INDUCED DISABILITY WITH AGING Open
Influenza (flu) is problematic for the elderly with increased severity of infection and greater risk for hospitalization and death. Primary flu infection is limited to pulmonary epithelial cells; yet myalgias are a common symptom and elder…
View article: INFLUENZA-INDUCED MUSCLE DEGRADATION: A PATHWAY TO AGE-ASSOCIATED DISABILITY
INFLUENZA-INDUCED MUSCLE DEGRADATION: A PATHWAY TO AGE-ASSOCIATED DISABILITY Open
Influenza (flu) is problematic for the elderly with increased severity of infection and greater risk for hospitalization and death. Flu infection is limited to pulmonary epithelial cells; yet myalgias are a common symptom and elderly are a…
View article: Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy
Aging augments the impact of influenza respiratory tract infection on mobility impairments, muscle-localized inflammation, and muscle atrophy Open
Although the influenza virus only infects the respiratory system, myalgias are commonly experienced during infection. In addition to a greater risk of hospitalization and death, older adults are more likely to develop disability following …