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View article: <i>Alk</i> — <i>Fam150b</i> (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress
<i>Alk</i> — <i>Fam150b</i> (augmentor α) expression in the paraventricular nucleus of the mouse hypothalamus at molecular resolution, and its sensitivity to acute stress Open
Augmentor α ( Fam150b ) action on the ALK receptor ( Alk ) has gained significance as a hypothalamic signaling pathway with relevance to the control of food intake and energy homeostasis. In contrast, much less is known about the sensitivi…
View article: Corrigendum to “Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice” [MOLMET 85 (2024) 1–16]
Corrigendum to “Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice” [MOLMET 85 (2024) 1–16] Open
View article: Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice
Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice Open
View article: Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus
Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus coeruleus Open
The locus coeruleus (LC) is a small nucleus in the pons from which ascending and descending projections innervate major parts of the central nervous system. Its major transmitter is norepinephrine (NE). This system is evolutionarily conser…
View article: Persistent binding at dopamine transporters determines sustained psychostimulant effects
Persistent binding at dopamine transporters determines sustained psychostimulant effects Open
Psychostimulants interacting with the dopamine transporter (DAT) can be used illicitly or for the treatment of specific neuropsychiatric disorders. However, they can also produce severe and persistent adverse events. Often, their pharmacol…
View article: The metabolic regulator USF-1 is involved in the control of affective behaviour in mice
The metabolic regulator USF-1 is involved in the control of affective behaviour in mice Open
Epidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, and mood disorders, most prominently major depression. However, the biological mechanisms media…
View article: Serotonin-releasing agents with reduced off-target effects
Serotonin-releasing agents with reduced off-target effects Open
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g., social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studi…
View article: Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner
Uncoupling Protein-1 Modulates Anxiety-Like Behavior in a Temperature-Dependent Manner Open
A strong bidirectional link between metabolic and psychiatric disorders exists; yet, the molecular basis underlying this interaction remains unresolved. Here we explored the role of the brown adipose tissue (BAT) as modulatory interface, f…
View article: Microdystrophin Therapy Rescues Impaired Na Currents in Cardiac Purkinje Fibers From Dystrophin-Deficient Mdx Mice
Microdystrophin Therapy Rescues Impaired Na Currents in Cardiac Purkinje Fibers From Dystrophin-Deficient Mdx Mice Open
View article: Serotonin-releasing agents with reduced off-target effects
Serotonin-releasing agents with reduced off-target effects Open
Increasing extracellular levels of serotonin (5-HT) in the brain ameliorates symptoms of depression and anxiety-related disorders, e.g. social phobias and post-traumatic stress disorder. Recent evidence from preclinical and clinical studie…
View article: The metabolic regulator USF1 is involved in the control of affective behaviour in mice
The metabolic regulator USF1 is involved in the control of affective behaviour in mice Open
Epidemiological studies indicate a bidirectional association between metabolic disturbances, including obesity and related pathological states, and mood disorders, most prominently major depression. However, the biological mechanisms media…
View article: Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain
Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain Open
The rising opioid crisis has become a worldwide societal and public health burden, resulting from the abuse of prescription opioids. Targeting the κ-opioid receptor (KOR) in the periphery has emerged as a powerful approach to develop novel…
View article: Psychomotor stimulant effects of α-pyrrolidinovalerophenone (αPVP) enantiomers correlate with drug binding kinetics at the dopamine transporter
Psychomotor stimulant effects of α-pyrrolidinovalerophenone (αPVP) enantiomers correlate with drug binding kinetics at the dopamine transporter Open
α-Pyrrolidinovalerophenone (αPVP) is a psychostimulant and drug of abuse associated with severe intoxications in humans. αPVP exerts long-lasting psychostimulant effects, when compared to the classical dopamine transporter (DAT) inhibitor …
View article: STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology
STAT3 in the dorsal raphe gates behavioural reactivity and regulates gene networks associated with psychopathology Open
The signal transducer and activator of transcription 3 (STAT3) signalling pathway is activated through phosphorylation by Janus kinases in response to a diverse set of immunogenic and non-immunogenic triggers. Several distinct lines of evi…
View article: VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring after Maternal Immune Activation
VEGF Treatment Ameliorates Depression-Like Behavior in Adult Offspring after Maternal Immune Activation Open
Maternal immune activation (MIA) during pregnancy impacts offspring neurodevelopmental trajectories and induces lifelong consequences, including emotional and cognitive alterations. Using the polyinosinic:polycytidilic acid (PIC) MIA model…
View article: Lmo3 deficiency in the mouse is associated with alterations in mood-related behaviors and a depression-biased amygdala transcriptome
Lmo3 deficiency in the mouse is associated with alterations in mood-related behaviors and a depression-biased amygdala transcriptome Open
The highly conserved transcription factor LIM-only 3 (Lmo3) is involved in important neurodevelopmental processes in several brain areas including the amygdala, a central hub for the generation and regulation of emotions. Accordingly, a ro…
View article: Maternal immune activation during pregnancy impacts on brain structure and function in the adult offspring
Maternal immune activation during pregnancy impacts on brain structure and function in the adult offspring Open
Gestational infection constitutes a risk factor for the occurrence of psychiatric disorders in the offspring. Activation of the maternal immune system (MIA) with subsequent impact on the development of the fetal brain is considered to form…
View article: Flotillin‐1 interacts with the serotonin transporter and modulates chronic corticosterone response
Flotillin‐1 interacts with the serotonin transporter and modulates chronic corticosterone response Open
Aberrant serotonergic neurotransmission in the brain is considered at the core of the pathophysiological mechanisms involved in neuropsychiatric disorders. Gene by environment interactions contribute to the development of depression and in…