Spyros A. Papiris
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View article: Long-Term Lung Sequelae in Survivors of Severe/Critical COVID-19 Pneumonia: The “Non-Steroid”, “Non-Interventional” Approach
Long-Term Lung Sequelae in Survivors of Severe/Critical COVID-19 Pneumonia: The “Non-Steroid”, “Non-Interventional” Approach Open
Introduction: Long-term lung sequelae in severe COVID-19 survivors, as well as their treatment, are poorly described in the current literature. Objective: To investigate lung fibrotic sequelae in survivors of severe/critical COVID-19 pneum…
View article: Childhood interstitial lung disease survivors in adulthood: a European collaborative study
Childhood interstitial lung disease survivors in adulthood: a European collaborative study Open
Background Interstitial lung disease is rarer in children than adults, but, with increasing diagnostic awareness, more cases are being discovered. The prognosis of childhood interstitial lung disease is often poor, but increasing numbers a…
View article: Chest Wall Deformities in Adults With Fibrotic Interstitial Lung Disease Related to Surfactant-Related Gene Mutations
Chest Wall Deformities in Adults With Fibrotic Interstitial Lung Disease Related to Surfactant-Related Gene Mutations Open
View article: Similarities and differences of interstitial lung disease associated with pathogenic variants in <scp><i>SFTPC</i></scp> and <scp><i>ABCA3</i></scp> in adults
Similarities and differences of interstitial lung disease associated with pathogenic variants in <span><i>SFTPC</i></span> and <span><i>ABCA3</i></span> in adults Open
Background and Objective Variants in surfactant genes SFTPC or ABCA3 are responsible for interstitial lung disease (ILD) in children and adults, with few studies in adults. Methods We conducted a multicentre retrospective study of all cons…
View article: <i>CSF2RB</i>mutation-related hereditary pulmonary alveolar proteinosis: the “long and winding road” into adulthood
<i>CSF2RB</i>mutation-related hereditary pulmonary alveolar proteinosis: the “long and winding road” into adulthood Open
Genetic analysis pre-lung transplantation diagnosed a case of hereditary pulmonary alveolar proteinosis (PAP) complicated by fibrosis in adulthood. The need for genetic testing in GM-CSF autoantibody negative and unclassifiable PAP is h…
View article: Lung transplantation outcome in adult surfactant-related interstitial lung disease: first evidence to move on
Lung transplantation outcome in adult surfactant-related interstitial lung disease: first evidence to move on Open
A new study reports the first evidence to "move on" with lung transplantation in adult surfactant-related fibrotic ILDs. It highlights the need for better genetic characterisation of transplant candidates and cancer screening for these …
View article: Patients Hospitalized for COVID-19 in the Periods of Delta and Omicron Variant Dominance in Greece: Determinants of Severity and Mortality
Patients Hospitalized for COVID-19 in the Periods of Delta and Omicron Variant Dominance in Greece: Determinants of Severity and Mortality Open
Background: Coronavirus disease 2019 (COVID-19) has been a pandemic since 2020, and depending on the SARS-CoV-2 mutation, different pandemic waves have been observed. The aim of this study was to compare the baseline characteristics of pat…
View article: Epidemiological characteristics, clinical featuresand outcomes of patients with COVID-19 admittedto seven reference centers across Greece: Anobservational study during the fourth and fifth wavesof the COVID-19 pandemic
Epidemiological characteristics, clinical featuresand outcomes of patients with COVID-19 admittedto seven reference centers across Greece: Anobservational study during the fourth and fifth wavesof the COVID-19 pandemic Open
1. Amin R, Sohrabi MR, Zali AR, Hannani K. Five consecutive epidemiological waves of COVID-19: a population-based cross-sectional study on characteristics, policies, and health outcome. BMC Infect Dis. 2022;22(1):906. doi:10.1186/s12879-02…
View article: From Karl Wurm and Guy Scadding's staging to 18F-FDG PET/CT scan phenotyping and far beyond: perspective in the evading history of phenotyping in sarcoidosis
From Karl Wurm and Guy Scadding's staging to 18F-FDG PET/CT scan phenotyping and far beyond: perspective in the evading history of phenotyping in sarcoidosis Open
Sarcoidosis is an inflammatory granulomatous disease of unknown etiology involving any organ or tissue along with any combination of active sites, even the most silent ones clinically. The unpredictable nature of the sites involved in sarc…
View article: Diffuse panniculitis in a teenage male with ZZ α<sub>1</sub>-antitrypsin deficiency
Diffuse panniculitis in a teenage male with ZZ α<sub>1</sub>-antitrypsin deficiency Open
Diffuse panniculitis is a rare manifestation of α1-ATD, albeit perhaps the most fulminant and life-threatening complication, associated usually with ZZ phenotype. Intravenous α1-AT treatment is lifesaving. http…
View article: Effects of short-term air pollution exposure on symptoms development in the course of idiopathic pulmonary fibrosis
Effects of short-term air pollution exposure on symptoms development in the course of idiopathic pulmonary fibrosis Open
Lately a potential detrimental effect of air pollution to idiopathic pulmonary fibrosis emerged. We aimed to assess the effects of short-term air pollution exposure to the clinical course of IPF. IPF patients were followed intensively for …
View article: Nursing home elderly patients hospitalized for <scp>COVID</scp>‐19: Characteristics and predictors of outcomes
Nursing home elderly patients hospitalized for <span>COVID</span>‐19: Characteristics and predictors of outcomes Open
View article: Genetics in Idiopathic Pulmonary Fibrosis: A Clinical Perspective
Genetics in Idiopathic Pulmonary Fibrosis: A Clinical Perspective Open
Background: Unraveling the genetic background in a significant proportion of patients with both sporadic and familial IPF provided new insights into the pathogenic pathways of pulmonary fibrosis. Aim: The aim of the present study is to ove…
View article: Effects of short- and long-term air pollution exposure on the course of idiopathic pulmonary fibrosis
Effects of short- and long-term air pollution exposure on the course of idiopathic pulmonary fibrosis Open
Background & Aim: Urban air pollution has recently emerged as a significant risk factor for developing IPF Acute Exacerbation (AE-IPF). The aim of this study was to simultaneously investigate the effects of short- and long-term ambient air…
View article: COVID-19 in patients with pulmonary alveolar proteinosis: a European multicentre study
COVID-19 in patients with pulmonary alveolar proteinosis: a European multicentre study Open
Adult PAP patients experience similar #COVID19 rates to the general population, and high rates of hospitalisation and deaths, underscoring their vulnerability and the need for measures to prevent infection. The impact of iGM-CSF must be…
View article: IPF-Acute Exacerbations: Advances and Future Perspectives
IPF-Acute Exacerbations: Advances and Future Perspectives Open
OPINION article Front. Pharmacol., 14 April 2022Sec. Experimental Pharmacology and Drug Discovery https://doi.org/10.3389/fphar.2022.836553
View article: Autoimmune pulmonary alveolar proteinosis in children
Autoimmune pulmonary alveolar proteinosis in children Open
In childhood, a multitude of causes lead to pulmonary alveolar proteinosis (PAP), an excessive surfactant accumulation in the alveolar space, limiting gas exchange. Autoantibodies against granulocyte–macrophage colony-stimulating factor (G…
View article: Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis
Long-term personal air pollution exposure and risk for acute exacerbation of idiopathic pulmonary fibrosis Open
View article: MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression
MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression Open
View article: Early COVID-19 lockdown in Greece and idiopathic pulmonary fibrosis: a beneficial “impact” beyond any expectation
Early COVID-19 lockdown in Greece and idiopathic pulmonary fibrosis: a beneficial “impact” beyond any expectation Open
During the lockdown, IPF patients experienced lower than expected COVID-19, suggesting that simple measures for the winter months, such as face masking, clean hands, physical distancing could be adopted as promising advances in non-phar…
View article: Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis
Inhaled Molgramostim Therapy in Autoimmune Pulmonary Alveolar Proteinosis Open
In patients with aPAP, daily administration of inhaled molgramostim resulted in greater improvements in pulmonary gas transfer and functional health status than placebo, with similar rates of adverse events. (Funded by Savara Pharmaceutica…
View article: First heterozygous<i>NOP10</i>mutation in familial pulmonary fibrosis
First heterozygous<i>NOP10</i>mutation in familial pulmonary fibrosis Open
We provide first evidence that a heterozygous NOP10 mutation (c.17A>G,p.Tyr6Cys) identified in a large family co-segregates with adult-onset familial PF and predisposes to short telomere syndrome (familial PF, liver, haematologic…
View article: The Significance of Clinical Awareness of Anatomical Variations
The Significance of Clinical Awareness of Anatomical Variations Open
So far, diverse congenital anatomical variations have been recognized as a consequence of failed developmental process during early embryogenesis [...]
View article: Myelodysplastic syndromes and idiopathic pulmonary fibrosis: a dangerous liaison
Myelodysplastic syndromes and idiopathic pulmonary fibrosis: a dangerous liaison Open
View article: Bi-allelic missense<i>ABCA3</i>mutations in a patient with childhood ILD who reached adulthood
Bi-allelic missense<i>ABCA3</i>mutations in a patient with childhood ILD who reached adulthood Open
Children with ABCA3 mutations may survive beyond infancy and reach adulthood. Genetic mechanisms should always be examined in adult patients with childhood onset ILD and molecular analysis should be performed accordingly in speci…
View article: Primary Hemangiopericytoma Arising in Extralobar Pulmonary Sequestration: A Coincidence or Two Rare Disorders?
Primary Hemangiopericytoma Arising in Extralobar Pulmonary Sequestration: A Coincidence or Two Rare Disorders? Open
Pulmonary HPC can arise in EPS. Surgical excision is the treatment of choice.
View article: <i>MUC5B</i> Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease
<i>MUC5B</i> Promoter Variant and Rheumatoid Arthritis with Interstitial Lung Disease Open
We found that the MUC5B promoter variant was associated with RA-ILD and more specifically associated with evidence of usual interstitial pneumonia on imaging. (Funded by Société Française de Rhumatologie and others.).
View article: Desert dust outbreaks and respiratory morbidity in Athens, Greece
Desert dust outbreaks and respiratory morbidity in Athens, Greece Open
View article: Exhaled Breath Condensate Acidification Occurs During Surgery for Abdominal Cancer
Exhaled Breath Condensate Acidification Occurs During Surgery for Abdominal Cancer Open
EBC acidification occurs in patients undergoing abdominal cancer resection and is associated with the occurrence of acute bronchospasm intraoperatively.
View article: Activin A and follistatin in patients with asthma. Does severity make the difference?
Activin A and follistatin in patients with asthma. Does severity make the difference? Open
Background and objective Activin A is a pleiotropic cytokine holding a fundamental role in inflammation and tissue remodelling. Follistatin can modulate the bioactivity of activin. We aimed to measure activin A and follistatin in sputum su…