Sreenivas Avula
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View article: Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis
Discovery of novel fluorescent amino-pyrazolines that detect and kill Mycobacterium tuberculosis Open
The emergence of multidrug-resistant Mycobacterium tuberculosis (MDR-TB) necessitates novel therapeutics with distinct mechanisms. Here, we report amino-pyrazoline derivatives as a new class of dual-functional antimycobacterial agents, int…
View article: Achieving Long‐Wavelength Electroluminescence Using Two‐Coordinate Gold(I) Complexes: Overcoming the Energy Gap Law
Achieving Long‐Wavelength Electroluminescence Using Two‐Coordinate Gold(I) Complexes: Overcoming the Energy Gap Law Open
Two‐coordinate coinage metal complexes have emerged as promising emitters for highly efficient organic light‐emitting devices (OLEDs). However, achieving efficient long‐wavelength electroluminescence emission from these complexes remains a…
View article: Wernicke-Korsakoff Syndrome From Hyperemesis Gravidarum
Wernicke-Korsakoff Syndrome From Hyperemesis Gravidarum Open
To editor: Wernicke encephalopathy (WE) is an acute neurological disorder caused by a deficiency of vitamin B1 (thiamine), with a prevalence of 1.3% in autopsy studies.1 Eighty-four percent of patients with WE will develop Korsakoff syndro…
View article: Design and biological evaluation of substituted 5,7-dihydro-6 <i>H</i> -indolo[2,3- <i>c</i> ]quinolin-6-one as novel selective Haspin inhibitors
Design and biological evaluation of substituted 5,7-dihydro-6 <i>H</i> -indolo[2,3- <i>c</i> ]quinolin-6-one as novel selective Haspin inhibitors Open
A library of substituted indolo[2,3-c]quinolone-6-ones was developed as simplified Lamellarin isosters. Synthesis was achieved from indole after a four-step pathway sequence involving iodination, a Suzuki-Miyaura cross-coupling reaction, a…
View article: A Case of a Seven-Year-old boy with Epilepsy with Myoclonic Absence: Importance of Seizure Semiology, Genetic Etiology, and Electroencephalogram Correlation for Timely Intervention
A Case of a Seven-Year-old boy with Epilepsy with Myoclonic Absence: Importance of Seizure Semiology, Genetic Etiology, and Electroencephalogram Correlation for Timely Intervention Open
Epilepsy with myoclonic absence (EMA) is a rare disorder with a mean age of onset of 7 years. It is characterized clinically by rhythmic, myoclonic jerking of the head, extremities or both, with impairment of consciousness and an ictal ele…
View article: Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration
Characterization of Co-Formulated High-Concentration Broadly Neutralizing Anti-HIV-1 Monoclonal Antibodies for Subcutaneous Administration Open
The discovery of numerous potent and broad neutralizing antibodies (bNAbs) against Human Immunodeficiency Virus type 1 (HIV-1) envelope glycoprotein has invigorated the potential of using them as an effective preventative and therapeutic a…
View article: CCDC 1475514: Experimental Crystal Structure Determination
CCDC 1475514: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1475513: Experimental Crystal Structure Determination
CCDC 1475513: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …