Sriganesh Jammula
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View article: Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma
Inhibition of AKT enhances chemotherapy efficacy and synergistically interacts with targeting of the Inhibitor of apoptosis proteins in oesophageal adenocarcinoma Open
The incidence of oesophageal adenocarcinoma (OAC) has risen six-fold in western countries over the last forty years but survival rates have only marginally improved. Hyperactivation of the PI3K-AKT-mTOR pathway is a common occurrence in OA…
View article: Author Correction: Disentangling oncogenic amplicons in esophageal adenocarcinoma
Author Correction: Disentangling oncogenic amplicons in esophageal adenocarcinoma Open
View article: Disentangling oncogenic amplicons in esophageal adenocarcinoma
Disentangling oncogenic amplicons in esophageal adenocarcinoma Open
Esophageal adenocarcinoma is a prominent example of cancer characterized by frequent amplifications in oncogenes. However, the mechanisms leading to amplicons that involve breakage-fusion-bridge cycles and extrachromosomal DNA are poorly u…
View article: Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation
Multi-Omic Analysis of Esophageal Adenocarcinoma Uncovers Candidate Therapeutic Targets and Cancer-Selective Posttranscriptional Regulation Open
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View article: Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma
Multicentre validation of CT grey-level co-occurrence matrix features for overall survival in primary oesophageal adenocarcinoma Open
View article: Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma
Mutational signature dynamics shaping the evolution of oesophageal adenocarcinoma Open
View article: The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes
The transcriptional landscape of endogenous retroelements delineates esophageal adenocarcinoma subtypes Open
Most cancer types exhibit aberrant transcriptional activity, including derepression of retrotransposable elements (RTEs). However, the degree, specificity and potential consequences of RTE transcriptional activation may differ substantiall…
View article: Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus
Extrachromosomal DNA in the cancerous transformation of Barrett’s oesophagus Open
View article: Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus
Extrachromosomal DNA in the cancerous transformation of Barrett’s esophagus Open
BACKGROUND Oncogenes are commonly amplified on extrachromosomal DNA (ecDNA) contributing to poor outcomes for patients. Currently, the chronology of ecDNA development is not known. We studied the origination and evolution of ecDNA in patie…
View article: Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas
Rearrangement processes and structural variations show evidence of selection in oesophageal adenocarcinomas Open
View article: Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity
Multi-omic cross-sectional cohort study of pre-malignant Barrett’s esophagus reveals early structural variation and retrotransposon activity Open
Barrett’s esophagus is a pre-malignant lesion that can progress to esophageal adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146 patients with a range of outcomes, comprising 642 person years of follow-up. Whol…
View article: P-OGC44 Multi-omic cohort study of Barrett’s oesophagus reveals structural variation and retrotransposon activity to occur early in cancer evolution
P-OGC44 Multi-omic cohort study of Barrett’s oesophagus reveals structural variation and retrotransposon activity to occur early in cancer evolution Open
Background Barrett’s oesophagus (BE) is the main risk factor for the development of oesophageal adenocarcinoma (OAC), yet few patients ever go on to progress to cancer. The acquisition of events during the metaplasia-dysplasia-cancer seque…
View article: Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments
Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments Open
Polyploidy is present in many cancer types and is increasingly recognized as an important factor in promoting chromosomal instability, genome evolution, and heterogeneity in cancer cells. However, the mechanisms that trigger polyploidy in …
View article: Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments
Evidence that polyploidy in esophageal adenocarcinoma originates from mitotic slippage caused by defective chromosome attachments Open
Polyploidy is present in many cancer types and is increasingly recognized as an important factor in promoting chromosomal instability, genome evolution, and heterogeneity in cancer cells. However, the mechanisms that trigger polyploidy in …
View article: Machine Classification of Methylomes in Cancer
Machine Classification of Methylomes in Cancer Open
Cancer remains a leading cause of morbidity and mortality worldwide. Its evolutionary nature and resultant complex interactions with the tumour micro-environment and the host immune system engender heterogeneity, make developing interventi…
View article: Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data
Identification of Subtypes of Barrett’s Esophagus and Esophageal Adenocarcinoma Based on DNA Methylation Profiles and Integration of Transcriptome and Genome Data Open
View article: PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin
PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin Open
View article: Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma
Patient-specific cancer genes contribute to recurrently perturbed pathways and establish therapeutic vulnerabilities in esophageal adenocarcinoma Open
View article: FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway
FBXW5 Promotes Tumorigenesis and Metastasis in Gastric Cancer via Activation of the FAK-Src Signaling Pathway Open
F-box/WD repeat-containing protein 5 (FBXW5) is a member of the FBXW subclass of F-box proteins. Despite its known function as a component of the Skp1-Cullin-F-box (SCF) ubiquitin ligase complex, the role of FBXW5 in gastric cancer tumorig…
View article: The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic
The landscape of selection in 551 esophageal adenocarcinomas defines genomic biomarkers for the clinic Open
View article: DNA Methylation Biomarkers for the Diagnosis of Barrett's Oesophagus
DNA Methylation Biomarkers for the Diagnosis of Barrett's Oesophagus Open
Kosmidou, Cassandra BSc, MRes1; Jammula, Sriganesh BSc, PhD2; Fitzgerald, Rebecca C. MD, FRCP, FMedSci1Author Information
View article: Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts
Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts Open
View article: Low-cost and clinically applicable copy number profiling using repeat DNA
Low-cost and clinically applicable copy number profiling using repeat DNA Open
Large-scale cancer genome studies suggest that tumors are driven by somatic copy number alterations (SCNAs) or single-nucleotide variants (SNVs). Due to the low-cost, the clinical use of genomics assays is biased towards targeted gene pane…
View article: Selection and Application of Tissue microRNAs for Nonendoscopic Diagnosis of Barrett’s Esophagus
Selection and Application of Tissue microRNAs for Nonendoscopic Diagnosis of Barrett’s Esophagus Open
View article: The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic
The landscape of selection in 551 Esophageal Adenocarcinomas defines genomic biomarkers for the clinic Open
Esophageal Adenocarcinoma (EAC) is a poor prognosis cancer type with rapidly rising incidence. Our understanding of genetic events which drive EAC development is limited and there are few molecular biomarkers for prognostication or therape…
View article: Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice
Maintenance of leukemic cell identity by the activity of the Polycomb complex PRC1 in mice Open
The Polycomb complex PRC1 is a gatekeeper of leukemic cell identity in the presence of distinct oncogenic signals.
View article: Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity
Polycomb Complex PRC1 Preserves Intestinal Stem Cell Identity by Sustaining Wnt/β-Catenin Transcriptional Activity Open