Srikant Rangaraju
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View article: Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies
Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies Open
In Alzheimer's disease (AD) and other tauopathies, tau dissociates from microtubules and forms toxic aggregates that contribute to neurodegeneration. Although some of the pathological interactions of tau have been identified from postmorte…
View article: Multi-scale integration of human brain vascular and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk
Multi-scale integration of human brain vascular and CSF proteomes reveals biomarkers of cerebral amyloid angiopathy linked to Alzheimer’s disease risk Open
Summary Cerebrovascular disease frequently co-occurs with amyloid-β (Aβ) plaques and tau tangles, the pathological hallmarks of Alzheimer’s disease (AD), compounding cognitive decline. Aβ deposition is also central to cerebral amyloid angi…
View article: Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons
Neuroinflammatory Stress Preferentially Impacts Synaptic MAPK Signaling and Mitochondria in Excitatory Neurons Open
Background: Understanding synapse-specific effects of neuroinflammation can provide mechanistic and therapeutically relevant insights across the spectrum of neurological diseases. Methods: We applied neuron-specific proteomic biotinylation…
View article: Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis
Blood-based protein biomarkers of sickle cell disease pain: a systematic review and meta-analysis Open
Pain is a major complication of sickle cell disease (SCD), and persons with SCD experience acute vaso-occlusive pain episodes (VOEs). Many adults with SCD also develop chronic pain (CP). We conducted a systematic review and meta-analysis (…
View article: Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling
Simultaneous profiling of native-state proteomes and transcriptomes of neural cell types using proximity labeling Open
Deep molecular phenotyping of cells at transcriptomic and proteomic levels is an essential first step to understanding cellular contributions to development, aging, injury, and disease. Since proteome and transcriptome level abundances onl…
View article: Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies
Proximity labeling of the Tau repeat domain enriches RNA-binding proteins that are altered in Alzheimer’s disease and related tauopathies Open
In Alzheimer’s disease (AD) and other tauopathies, tau dissociates from microtubules and forms toxic aggregates that contribute to neurodegeneration. Although some of the pathological interactions of tau have been identified from postmorte…
View article: Multi-Scale Integration of Human Brain Vascular and CSF Proteomes Reveals Biomarkers of Cerebral Amyloid Angiopathy Linked to Alzheimer’s Disease Risk
Multi-Scale Integration of Human Brain Vascular and CSF Proteomes Reveals Biomarkers of Cerebral Amyloid Angiopathy Linked to Alzheimer’s Disease Risk Open
View article: Kv1.3 regulation of brain immune function <i>in vitro</i> and <i>in vivo</i>
Kv1.3 regulation of brain immune function <i>in vitro</i> and <i>in vivo</i> Open
Background In neurodegenerative disease such as Alzheimer’s disease and stroke, the brain transitions to pro‐inflammatory profile, where microglia and T‐cells in the brain have increase inflammatory profiles, along with increased Kv1.3 pot…
View article: In vivo TurboID labeling for paired proteomic and transcriptomic profiling of neurons and astrocytes
In vivo TurboID labeling for paired proteomic and transcriptomic profiling of neurons and astrocytes Open
Background Our group has developed the innovative proximity labeling cell‐type specific in vivo biotinylation of proteins (CIBOP) approach to quantify cell‐specific in vivo proteomic and transcriptomic signatures that may lead to identify …
View article: Neuropathological and cell type‐specific effects of Kv1.3 blockers in a pre‐clinical AD mouse model
Neuropathological and cell type‐specific effects of Kv1.3 blockers in a pre‐clinical AD mouse model Open
Background Kv1.3 channels are promising therapeutic targets to modulate neuroinflammatory responses in neurodegenerative disease including Alzheimer’s disease (AD). Although the ability of Kv1.3 blockers to reduce neuropathology in AD mous…
View article: Aβ re‐wires CSF1R‐induced MAPK pathway activation in MMC microglia
Aβ re‐wires CSF1R‐induced MAPK pathway activation in MMC microglia Open
Background Mitogen activated protein kinase (MAPK) signaling is a critical regulator of microglial phenotype, including phagocytic function, cytokine expression, and motility, among others. Importantly, both canonical and non‐canonical MAP…
View article: Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons
Neuroinflammatory Stress Exerts Distinct Proteomic Effects on Soma, Synapses and Mitochondria in Excitatory Neurons Open
Background Neuroinflammation plays a critical role in Alzheimer’s disease pathogenesis. Neurons are anatomically divided in subcellular compartments (axons, soma, and synapses), which may be distinctly impacted by neuroinflammation. This s…
View article: Matched Proteomics of Cerebrospinal Fluid and Brain Reveals Conserved and Discordant Mechanisms of Progressive Aβ Pathology in Mice
Matched Proteomics of Cerebrospinal Fluid and Brain Reveals Conserved and Discordant Mechanisms of Progressive Aβ Pathology in Mice Open
Background Cerebrospinal fluid (CSF) is an important source of protein biomarkers for diagnosis, risk stratification, and predicting treatment response in Alzheimer's disease (AD). Proximity to brain parenchyma suggests that CSF proteomic …
View article: Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease
Integrative proteomics identifies a conserved Aβ amyloid responsome, novel plaque proteins, and pathology modifiers in Alzheimer’s disease Open
View article: Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology
Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology Open
Dysfunction in fast-spiking parvalbumin interneurons (PV-INs) may represent an early pathophysiological perturbation in Alzheimer’s Disease (AD). Defining early proteomic alterations in PV-INs can provide key biological and translationally…
View article: Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia
Proximity labeling proteomics reveals Kv1.3 potassium channel immune interactors in microglia Open
Microglia are the resident immune cells of the brain and regulate the brain’s inflammatory state. In neurodegenerative diseases, microglia transition from a homeostatic state to a state referred to as disease associated microglia (DAM). DA…
View article: Proteomic Changes in the Human Cerebrovasculature in Alzheimer’s Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid
Proteomic Changes in the Human Cerebrovasculature in Alzheimer’s Disease and Related Tauopathies Linked to Peripheral Biomarkers in Plasma and Cerebrospinal Fluid Open
Dysfunction of the neurovascular unit stands as a significant pathological hallmark of Alzheimer’s disease (AD) and age-related neurodegenerative diseases. Nevertheless, detecting vascular changes in the brain within bulk tissues has prove…
View article: Exploring the multimeric tau interactome and its convergence with human tauopathy
Exploring the multimeric tau interactome and its convergence with human tauopathy Open
Background Neurofibrillary tangles (NFTs) comprised of the phosphorylated Tau protein are a core pathological feature of Alzheimer’s disease (AD) and several other neurodegenerative diseases collectively termed tauopathies include progress…
View article: Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model
Age‐Dependent Changes in Perineuronal Nets and Associated Parvalbumin Interneurons in the 5xFAD Amyloidosis Mouse Model Open
Background Perineuronal nets (PNNs) are extracellular matrix structures that surround neurons and proximal dendrites and regulate synaptic transmission, plasticity, and several facets of memory. PNNs are commonly associated with parvalbumi…
View article: Immune regulatory roles for Kv1.3 channels in Microglia in Alzheimer’s Disease
Immune regulatory roles for Kv1.3 channels in Microglia in Alzheimer’s Disease Open
Background In Alzheimer’s Disease (AD), a sub‐population of disease associated microglia present increased Kv1.3 channel abundance. Pharmacological blockade of Kv1.3 reduces Aβ pathology and dampens pro‐inflammatory function of microglia. …
View article: In vivo TurboID proximity labeling to capture astrocyte proteomic and transcriptomic signatures under homeostatic and neuroinflammatory conditions
In vivo TurboID proximity labeling to capture astrocyte proteomic and transcriptomic signatures under homeostatic and neuroinflammatory conditions Open
Background Despite decades of research into the cellular and molecular contributions of brain cell types to Alzheimer’s disease (AD) pathogenesis, there are no glial‐specific disease‐modifying therapies. To address this, our group has deve…
View article: Identification of State-Specific Proteomic and Transcriptomic Signatures of Microglia-Derived Extracellular Vesicles
Identification of State-Specific Proteomic and Transcriptomic Signatures of Microglia-Derived Extracellular Vesicles Open
Microglia are resident immune cells of the brain that play important roles in mediating inflammatory responses in several neurological diseases via direct and indirect mechanisms. One indirect mechanism may involve extracellular vesicle (E…
View article: Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology Open
Preventative treatment for Alzheimer’s Disease is of dire importance, and yet, cellular mechanisms underlying early regional vulnerability in Alzheimer’s Disease remain unknown. In human patients with Alzheimer’s Disease, one of the earlie…
View article: Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology
Entorhinal cortex vulnerability to human APP expression promotes hyperexcitability and tau pathology Open
View article: Abstract 223: Pre‐Thrombectomy Diagnosis of Large Vessel Occlusion with Underlying Intracranial Atherosclerotic Disease
Abstract 223: Pre‐Thrombectomy Diagnosis of Large Vessel Occlusion with Underlying Intracranial Atherosclerotic Disease Open
Introduction Intracranial atherosclerotic disease (ICAD) is one of the leading causes of ischemic stroke. We sought to identify variables associated with ICAD underlying large vessel occlusion strokes (LVOS) to facilitate pre‐procedural di…
View article: Editorial: Environmental effect on neuroinflammation and neurodegeneration, volume II
Editorial: Environmental effect on neuroinflammation and neurodegeneration, volume II Open
EDITORIAL article Front. Cell. Neurosci., 11 August 2023Sec. Cellular Neuropathology Volume 17 - 2023 | https://doi.org/10.3389/fncel.2023.1269180
View article: Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles
Identification of state-specific proteomic and transcriptomic signatures of microglia-derived extracellular vesicles Open
Microglia are resident immune cells of the brain that play important roles in mediating inflammatory responses in several neurological diseases via direct and indirect mechanisms. One indirect mechanism may involve extracellular vesicle (E…
View article: Factors associated with stroke after COVID-19 vaccination: a statewide analysis
Factors associated with stroke after COVID-19 vaccination: a statewide analysis Open
Background The objective of our study was to evaluate vaccine type, COVID-19 infection, and their association with stroke soon after COVID-19 vaccination. Methods In a retrospective cohort study, we estimated the 21-day post-vaccination in…
View article: Telemedicine impact on post-stroke outpatient follow-up in an academic healthcare network during the COVID-19 pandemic
Telemedicine impact on post-stroke outpatient follow-up in an academic healthcare network during the COVID-19 pandemic Open
View article: Profiling the neuroimmune cascade in 3xTg mice exposed to successive mild traumatic brain injuries
Profiling the neuroimmune cascade in 3xTg mice exposed to successive mild traumatic brain injuries Open
Repetitive mild traumatic brain injuries (rmTBI) sustained within a window of vulnerability can result in long term cognitive deficits, depression, and eventual neurodegeneration associated with tau pathology, amyloid beta (Aβ) plaques, gl…