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View article: The minimal vesicular trafficking machinery of <i>Giardia</i> has two <scp>NSF</scp> paralogues
The minimal vesicular trafficking machinery of <i>Giardia</i> has two <span>NSF</span> paralogues Open
Vesicle fusion events are crucial for the survival of Giardia lamblia as they drive nutrient uptake and morphological stage transitions. Unlike most eukaryotes, Giardia has a minimal vesicular trafficking machinery. We report a rare except…
View article: Divergent functions of late ESCRT components in Giardia lamblia: Insights from subcellular distributions and protein interactions
Divergent functions of late ESCRT components in Giardia lamblia: Insights from subcellular distributions and protein interactions Open
Giardia lamblia , a human gut pathogen, possesses a minimal ESCRT (Endosomal Sorting Complex Required for Transport) machinery. Paradoxically, there are multiple paralogues of some late-ESCRT components- three paralogues for Vps4, GlVps4a,…
View article: Binary protein interactome mapping of the <i>Giardia lamblia</i> proteasome lid reveals extra proteasomal functions of <scp>GlRpn11</scp>
Binary protein interactome mapping of the <i>Giardia lamblia</i> proteasome lid reveals extra proteasomal functions of <span>GlRpn11</span> Open
The assembly of the 26S proteasome, a multi‐subunit complex for regulated protein turnover, proceeds via the formation of intermediates. Giardia lamblia does not encode proteasome regulatory subunit Rpn12 or proteasome complex subunit Sem1…
View article: Divergent Functions of Late ESCRT Components in<i>Giardia lamblia</i>: Insights from Subcellular Distributions and Protein Interactions
Divergent Functions of Late ESCRT Components in<i>Giardia lamblia</i>: Insights from Subcellular Distributions and Protein Interactions Open
Giardia lamblia , a human gut pathogen, possesses a minimal ESCRT (Endosomal Sorting Complex Required for Transport) machinery. Paradoxically, there are multiple paralogs of some late-ESCRT components. There are three paralogs for Vps4, Gl…
View article: Cigarette smoke impairs the endocytotic process in<i>Saccharomyces cerevisiae</i>
Cigarette smoke impairs the endocytotic process in<i>Saccharomyces cerevisiae</i> Open
The accumulation of misfolded proteins inside the cells has been considered to be an important contributor to the development of cigarette smoke-mediated diseases. Since endocytosis plays a crucial role in protein trafficking and clearance…
View article: Two paralogues of N-ethylmaleimide sensitive factor: An exception to the minimal vesicular trafficking machinery of<i>Giardia</i>
Two paralogues of N-ethylmaleimide sensitive factor: An exception to the minimal vesicular trafficking machinery of<i>Giardia</i> Open
Vesicular trafficking plays a critical role in the survival of the human gut pathogen Giardia lamblia as it drives nutrient uptake and morphological stage transition. Unlike most eukaryotes, Giardia has a minimal vesicular trafficking mach…
View article: Multiple paralogues of α-SNAP in Giardia lamblia exhibit independent subcellular localization and redistribution during encystation and stress
Multiple paralogues of α-SNAP in Giardia lamblia exhibit independent subcellular localization and redistribution during encystation and stress Open
None of the genes encoding the three α-SNAPs are pseudogenes and the encoded proteins are likely to discharge non-redundant functions in the different morphological states of G. lamblia. Based on the difference in the interaction of indivi…
View article: Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia
Variation in the ribosome interacting loop of the Sec61α from Giardia lamblia Open
View article: A reduced VWA domain-containing proteasomal ubiquitin receptor of Giardia lamblia localizes to the flagellar pore regions in microtubule-dependent manner
A reduced VWA domain-containing proteasomal ubiquitin receptor of Giardia lamblia localizes to the flagellar pore regions in microtubule-dependent manner Open
GlRpn10 contains a noncanonical VWA domain that is partially functional in yeast. Besides the expected nuclear and cytosolic distribution, the protein displays microtubule-dependent flagellar pore localization in trophozoites. While the pr…