Srinath Sanda
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View article: HMPV Virus Outbreak: First Review in Literature
HMPV Virus Outbreak: First Review in Literature Open
A BSTRACT Human metapneumovirus (HMPV), a pathogen within the Pneumoviridae family, is a notable contributor to respiratory tract infections worldwide. Identified in 2001, HMPV predominantly affects young children, the elderly, and individ…
View article: Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure
Gut microbial bile and amino acid metabolism associate with peanut oral immunotherapy failure Open
View article: Photodynamic Therapy versus Surgery in Management of Oral Squamous Cell Carcinoma: A Comparative Study
Photodynamic Therapy versus Surgery in Management of Oral Squamous Cell Carcinoma: A Comparative Study Open
A BSTRACT Introduction: “Oral squamous cell carcinoma (OSCC)” is one of the most common malignancies of the oral cavity, often requiring aggressive surgical intervention. “Photodynamic therapy (PDT)” has emerged as a minimally invasive tre…
View article: Genetic Markers as Predictors of Prognosis and Treatment Response in Patients with Oral Cancer: A Prospective Study
Genetic Markers as Predictors of Prognosis and Treatment Response in Patients with Oral Cancer: A Prospective Study Open
A BSTRACT Introduction: “Oral squamous cell carcinoma (OSCC)” is a prevalent malignancy globally, with significant morbidity and mortality. Genetic markers are emerging as vital tools in predicting prognosis and treatment responses. This r…
View article: Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study
Efficacy and safety of oral immunotherapy in children aged 1–3 years with peanut allergy (the Immune Tolerance Network IMPACT trial): a randomised placebo-controlled study Open
View article: Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes
Early expansion of TIGIT+PD1+ effector memory CD4 T cells via agonistic effect of alefacept in new-onset type 1 diabetes Open
The CD2-depleting drug alefacept (LFA3-Ig) preserved beta cell function in new-onset type 1 diabetes (T1D) patients. The most promising biomarkers of response were late expansion of exhausted CD8 T cells and rare baseline inflammatory isle…
View article: Enhanced Gut Microbiome Capacity for Amino Acid Metabolism is associated with Peanut Oral Immunotherapy Failure
Enhanced Gut Microbiome Capacity for Amino Acid Metabolism is associated with Peanut Oral Immunotherapy Failure Open
Peanut Oral Immunotherapy (POIT) holds promise for remission of peanut allergy, though treatment is protracted and successful in only a subset of patients. Because the gut microbiome is linked to food allergy, we sought to identify fecal m…
View article: Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy
Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy Open
View article: Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy
Distinct trajectories distinguish antigen-specific T cells in peanut-allergic individuals undergoing oral immunotherapy Open
View article: HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success
HLA-associated outcomes in peanut oral immunotherapy trials identify mechanistic and clinical determinants of therapeutic success Open
Rationale Previous studies identified an interaction between HLA and oral peanut exposure. HLA-DQA1*01:02 had a protective role with the induction of Ara h 2 epitope-specific IgG4 associated with peanut consumption during the LEAP clinical…
View article: IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation
IL-6-Driven pSTAT1 Response Is Linked to T Cell Features Implicated in Early Immune Dysregulation Open
Elevated levels and enhanced sensing of the pro-inflammatory cytokine interleukin-6 (IL-6) are key features of many autoimmune and inflammatory diseases. To better understand how IL-6 signaling may influence human T cell fate, we investiga…
View article: Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy
Interpretation of Bone Mineral Density Z-Scores by Dual-Energy X-Ray Absorptiometry in Transgender and Gender Diverse Youth Prior to Gender-Affirming Medical Therapy Open
View article: IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes
IL-6 receptor blockade does not slow β cell loss in new-onset type 1 diabetes Open
Type 1 diabetes mellitus (T1DM) is an autoimmune disease. Based on previous research, study doctors think that giving medicines to affect the immune system soon after diabetes is diagnosed may stop, delay or decrease the destruction of bet…
View article: Approaches to Establishing Tolerance in Immune Mediated Diseases
Approaches to Establishing Tolerance in Immune Mediated Diseases Open
The development of rational approaches to restore immune tolerance requires an iterative approach that builds on past success and utilizes new mechanistic insights into immune-mediated pathologies. This article will review concepts that ha…
View article: Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial
Imatinib therapy for patients with recent-onset type 1 diabetes: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial Open
Juvenile Research Diabetes Foundation.
View article: Diabetic ketoacidosis drives <scp>COVID‐19</scp> related hospitalizations in children with type <scp>1</scp> diabetes
Diabetic ketoacidosis drives <span>COVID‐19</span> related hospitalizations in children with type <span>1</span> diabetes Open
Background Diabetes is a risk factor for poor COVID‐19 outcomes, but pediatric patients with type 1 diabetes are poorly represented in current studies. Methods T1D Exchange coordinated a US type 1 diabetes COVID‐19 registry. Forty‐six diab…
View article: Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy
Differential induction of allergen-specific IgA responses following timothy grass subcutaneous and sublingual immunotherapy Open
View article: Imatinib Therapy for Patients with Recent-Onset Type 1 Diabetes: A Randomised Blinded Phase 2 Trial
Imatinib Therapy for Patients with Recent-Onset Type 1 Diabetes: A Randomised Blinded Phase 2 Trial Open
View article: Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers
Inequities in Diabetic Ketoacidosis Among Patients With Type 1 Diabetes and COVID-19: Data From 52 US Clinical Centers Open
Objective We examined whether diabetic ketoacidosis (DKA), a serious complication of type 1 diabetes (T1D) was more prevalent among Non-Hispanic (NH) Black and Hispanic patients with T1D and laboratory-confirmed coronavirus disease 2019 (C…
View article: Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR
Sensitive detection of multiple islet autoantibodies in type 1 diabetes using small sample volumes by agglutination-PCR Open
Islet autoantibodies are predominantly measured by radioassay to facilitate risk assessment and diagnosis of type 1 diabetes. However, the reliance on radioactive components, large sample volumes and limited throughput renders radioassay t…
View article: Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen
Nasal allergen challenge and environmental exposure chamber challenge: A randomized trial comparing clinical and biological responses to cat allergen Open
View article: Tolerance Development Following Oral Immunotherapy (OIT) in 1-3 Year Old Children with Peanut Allergy: Findings from the Immune Tolerance Network (ITN) IMPACT TRIAL
Tolerance Development Following Oral Immunotherapy (OIT) in 1-3 Year Old Children with Peanut Allergy: Findings from the Immune Tolerance Network (ITN) IMPACT TRIAL Open
View article: Survival in a bad neighborhood: pancreatic islets in cystic fibrosis
Survival in a bad neighborhood: pancreatic islets in cystic fibrosis Open
In cystic fibrosis (CF), ductal plugging and acinar loss result in rapid decline of exocrine pancreatic function. This destructive process results in remodeled islets, with only a modest reduction in insulin-producing β cells. However, β-c…
View article: Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control
Hyaluronan levels are increased systemically in human type 2 but not type 1 diabetes independently of glycemic control Open
View article: Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes
Remodeling T cell compartments during anti-CD3 immunotherapy of type 1 diabetes Open
View article: Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests
Increasing ICA512 autoantibody titers predict development of abnormal oral glucose tolerance tests Open
ICA512 autoantibody titers associate with progressive abnormalities in glucose metabolism in subjects at risk for type 1 diabetes. Fluctuations in autoantibody titers do not correlate with lower rates of progression to clinical disease.
View article: Acute hyperglycemia impairs IL‐6 expression in humans
Acute hyperglycemia impairs IL‐6 expression in humans Open
Normal glucose metabolism is critical to immune function but the effects of short-term hyperglycemia on immunity are not well described. To study this phenomenon, we induced hyperglycemia in healthy subjects for 2 h with intravenous dextro…