Srinivas Madduri
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View article: Dose-dependent effects of hyperbaric oxygen on PC12 cell viability and neurite outgrowth with and without NGF stimulation
Dose-dependent effects of hyperbaric oxygen on PC12 cell viability and neurite outgrowth with and without NGF stimulation Open
Hyperbaric oxygen therapy (HBOT) is a promising approach to promote peripheral nerve regeneration. However, the underlying mechanisms of action are poorly understood resulting in inconsistent treatment protocols and unclear indications. Th…
View article: Clinical Safety and Efficacy of Allogeneic Adipose Stem Cells: A Systematic Review of the Clinical Trials
Clinical Safety and Efficacy of Allogeneic Adipose Stem Cells: A Systematic Review of the Clinical Trials Open
Allogeneic adipose stem cells (AASCs) are increasingly recognized for their potential in regenerative medicine. They offer a promising alternative to autologous cells, with potential advantages such as availability and reduced morbidity in…
View article: Can Humanized Immune System Mouse and Rat Models Accelerate the Development of Cytomegalovirus-Based Vaccines Against Infectious Diseases and Cancers?
Can Humanized Immune System Mouse and Rat Models Accelerate the Development of Cytomegalovirus-Based Vaccines Against Infectious Diseases and Cancers? Open
Over the past three decades, immunodeficient mouse models carrying human immune cells, with or without human lymphoid tissues, termed humanized immune system (HIS) rodent models, have been developed to recapitulate the human immune system …
View article: BILATERAL EPISIOTOMY FOR SUCCESSFUL PER VAGINAL DELIVERY OF TERATOLOGICAL TWIN FETUSES IN A DOE WITH VULVAL STENOSIS
BILATERAL EPISIOTOMY FOR SUCCESSFUL PER VAGINAL DELIVERY OF TERATOLOGICAL TWIN FETUSES IN A DOE WITH VULVAL STENOSIS Open
A full-term pregnant doe was presented with a history of dystocia. Ultrasonographic examination revealed the presence of two dead fetuses. On obstetrical examination, vulval stenosis was confirmed. Bilateral episiotomy was performed and tw…
View article: An Implantable Biohybrid Neural Interface Toward Synaptic Deep Brain Stimulation
An Implantable Biohybrid Neural Interface Toward Synaptic Deep Brain Stimulation Open
In patients with sensory nerve loss, such as those experiencing optic nerve damage that leads to vision loss, the thalamus no longer receives the corresponding sensory input. To restore functional sensory input, it is necessary to bypass t…
View article: 3D stem-like spheroids-on-a-chip for personalized combinatorial drug testing in oral cancer
3D stem-like spheroids-on-a-chip for personalized combinatorial drug testing in oral cancer Open
View article: Therapeutic Potential and Challenges of Mesenchymal Stem Cell-Derived Exosomes for Peripheral Nerve Regeneration: A Systematic Review
Therapeutic Potential and Challenges of Mesenchymal Stem Cell-Derived Exosomes for Peripheral Nerve Regeneration: A Systematic Review Open
Gap injuries to the peripheral nervous system result in pain and loss of function, without any particularly effective therapeutic options. Within this context, mesenchymal stem cell (MSC)-derived exosomes have emerged as a potential therap…
View article: Preconceptional paternal caloric restriction of high-fat diet-induced obesity in Wistar rats dysregulates the metabolism of their offspring via AMPK/SIRT1 pathway
Preconceptional paternal caloric restriction of high-fat diet-induced obesity in Wistar rats dysregulates the metabolism of their offspring via AMPK/SIRT1 pathway Open
View article: An implantable biohybrid nerve model towards synaptic deep brain stimulation
An implantable biohybrid nerve model towards synaptic deep brain stimulation Open
Restoring functional vision in blind patients lacking a healthy optic nerve requires bypassing retinal circuits, ideally, by directly stimulating the visual thalamus. However, available deep brain stimulation electrodes do not provide the …
View article: Sensory and pain outcomes of neurotized skin-grafted free gracilis muscle flaps for lower extremity reconstruction
Sensory and pain outcomes of neurotized skin-grafted free gracilis muscle flaps for lower extremity reconstruction Open
Mechanical detection, vibration detection, temperature detection, and two-point discrimination significantly improved over time but without reaching normal sensory function at 12 months postoperatively. Neuropathic pain resolved at 12 mont…
View article: Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia
Role of Oxygen and Its Radicals in Peripheral Nerve Regeneration: From Hypoxia to Physoxia to Hyperoxia Open
Oxygen is compulsory for mitochondrial function and energy supply, but it has numerous more nuanced roles. The different roles of oxygen in peripheral nerve regeneration range from energy supply, inflammation, phagocytosis, and oxidative c…
View article: Crafting code keepers: An in-depth exploration of talent management strategies for sustainable employee retention in the software industry
Crafting code keepers: An in-depth exploration of talent management strategies for sustainable employee retention in the software industry Open
The execution of initiatives that are focused at employee satisfaction is always required in order to maintain skilled human resources, regardless of whether the firm in question is small, medium, local, or global. The turnover rate of emp…
View article: Reporting of Mammary Tumours in Indigenously developed Spontaneous NIN/Sprague Dawley Mutant (Nude) Rat Strain
Reporting of Mammary Tumours in Indigenously developed Spontaneous NIN/Sprague Dawley Mutant (Nude) Rat Strain Open
Background: Breast cancer has been linked with many causes including nutrition. However spontaneous mammary tumour rodent model will unlock many such mechanisms. The past five decades, the ICMR-NIN animal facility has diligently maintained…
View article: Emerging Strategies for the Biofabrication of Multilayer Composite Amniotic Membranes for Biomedical Applications
Emerging Strategies for the Biofabrication of Multilayer Composite Amniotic Membranes for Biomedical Applications Open
The amniotic membrane (AM) is the innermost part of the fetal placenta, which surrounds and protects the fetus. Due to its structural components (stem cells, growth factors, and proteins), AMs display unique biological properties and are a…
View article: Mesenchymal Stem Cells in Nerve Tissue Engineering: Bridging Nerve Gap Injuries in Large Animals
Mesenchymal Stem Cells in Nerve Tissue Engineering: Bridging Nerve Gap Injuries in Large Animals Open
Cell-therapy-based nerve repair strategies hold great promise. In the field, there is an extensive amount of evidence for better regenerative outcomes when using tissue-engineered nerve grafts for bridging severe gap injuries. Although a m…
View article: Natural polysaccharides and their derivatives as potential medical materials and drug delivery systems for the treatment of peripheral nerve injuries
Natural polysaccharides and their derivatives as potential medical materials and drug delivery systems for the treatment of peripheral nerve injuries Open
Peripheral nerve repair following injury is one of the most serious problems in neurosurgery. Clinical outcomes are often unsatisfactory and associated with a huge socioeconomic burden. Several studies have revealed the great potential of …
View article: A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine
A comprehensive review of silk-fibroin hydrogels for cell and drug delivery applications in tissue engineering and regenerative medicine Open
View article: Therapeutic management of canine papilloma: a study of six cases
Therapeutic management of canine papilloma: a study of six cases Open
Clinical study was conducted in six different dog breeds aged between one to nine years were presented to Veterinary Clinical Complex, Rajiv Gandhi Institute of Veterinary Education and Research, Puducherry with a history of multiple cauli…
View article: The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation
The Role of Hippo Signaling Pathway and ILK in the Pathophysiology of Human Hypertrophic Scars and Keloids: An Immunohistochemical Investigation Open
Background: Keloids and hypertrophic scars are characterized by abnormal fibroblast activation and proliferation. While their molecular pathogenesis remains unclear, myofibroblasts have been associated with their development. Hippo pathway…
View article: Diagnostic and Therapeutic Roles of the “Omics” in Hypoxic–Ischemic Encephalopathy in Neonates
Diagnostic and Therapeutic Roles of the “Omics” in Hypoxic–Ischemic Encephalopathy in Neonates Open
Perinatal asphyxia and neonatal encephalopathy remain major causes of neonatal mortality, despite the improved availability of diagnostic and therapeutic tools, contributing to neurological and intellectual disabilities worldwide. An appro…
View article: Optimized Decellularization Protocol for Large Peripheral Nerve Segments: Towards Personalized Nerve Bioengineering
Optimized Decellularization Protocol for Large Peripheral Nerve Segments: Towards Personalized Nerve Bioengineering Open
Nerve injuries remain clinically challenging, and allografts showed great promise. Decellularized nerve allografts possess excellent biocompatibility and biological activity. However, the vast majority of decellularization protocols were e…
View article: Editorial: Emerging Therapeutic Approaches for Repair and Regeneration of Injuries in the Peripheral Nervous System
Editorial: Emerging Therapeutic Approaches for Repair and Regeneration of Injuries in the Peripheral Nervous System Open
EDITORIAL article Front. Bioeng. Biotechnol., 31 March 2022Sec. Tissue Engineering and Regenerative Medicine https://doi.org/10.3389/fbioe.2022.891459
View article: Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve
Comparative hard x-ray tomography for virtual histology of zebrafish larva, human tooth cementum, and porcine nerve Open
Purpose: Synchrotron radiation-based tomography yields microanatomical features in human and animal tissues without physical slicing. Recent advances in instrumentation have made laboratory-based phase tomography feasible. We compar…
View article: Synergy of human platelet lysate and laminin to enhance the neurotrophic effect of human adipose-derived stem cells
Synergy of human platelet lysate and laminin to enhance the neurotrophic effect of human adipose-derived stem cells Open
Despite the spontaneous regenerative capacity of the peripheral nervous system, clinical nerve repair often results in poor functional recovery with the high socio-economic burden. In presence of peripheral nerve injuries and when distal n…
View article: Studies on Progesterone Concentration and Fertility Response in Postpartum Subestrus Buffaloes during Breeding and Low Breeding Seasons
Studies on Progesterone Concentration and Fertility Response in Postpartum Subestrus Buffaloes during Breeding and Low Breeding Seasons Open
Background: The dairy and livestock sector plays a very important role in national economy of India by contributing close to one third of gross income of rural households and nearly half of gross income in case of those without land. Subes…
View article: Systematic Investigation and Comparison of US FDA-Approved Immunosuppressive Drugs FK506, Cyclosporine and Rapamycin for Neuromuscular Regeneration following Chronic Nerve Compression Injury
Systematic Investigation and Comparison of US FDA-Approved Immunosuppressive Drugs FK506, Cyclosporine and Rapamycin for Neuromuscular Regeneration following Chronic Nerve Compression Injury Open
Aim: To compare therapeutic benefits of different immunophilin ligands for treating nerve injuries. Materials & methods: Cyclosporine, FK506 and rapamycin, were evaluated first in vitro on a serum-free culture of embry…
View article: A New Model of Chronic Peripheral Nerve Compression for Basic Research and Pharmaceutical Drug Testing
A New Model of Chronic Peripheral Nerve Compression for Basic Research and Pharmaceutical Drug Testing Open
Aim: To develop a consistent model to standardize research in the field of chronic peripheral nerve neuropathy. Methods: The left sciatic nerve of 8-week-old Sprague-Dawley rats was compressed using a customized instrument le…
View article: Laboratory-based phase and absorption tomography for micro-imaging of annual layers in human tooth cementum, paraffin-embedded nerve and zebrafish embryo
Laboratory-based phase and absorption tomography for micro-imaging of annual layers in human tooth cementum, paraffin-embedded nerve and zebrafish embryo Open
Synchrotron radiation-based tomography yields the micro-anatomical features in human and animal tissues without physical slicing. Recent advances in instrumentation have made laboratory-based phase tomography feasible. We compared the perf…
View article: Clinical Studies and Pre-clinical Animal Models on Facial Nerve Preservation, Reconstruction, and Regeneration Following Cerebellopontine Angle Tumor Surgery–A Systematic Review and Future Perspectives
Clinical Studies and Pre-clinical Animal Models on Facial Nerve Preservation, Reconstruction, and Regeneration Following Cerebellopontine Angle Tumor Surgery–A Systematic Review and Future Perspectives Open
Background and purpose: Tumorous lesions developing in the cerebellopontine angle (CPA) get into close contact with the 1st (cisternal) and 2nd (meatal) intra-arachnoidal portion of the facial nerve (FN). When surgical damage occurs, commo…
View article: Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System
Schwann Cell-Like Cells: Origin and Usability for Repair and Regeneration of the Peripheral and Central Nervous System Open
Functional recovery after neurotmesis, a complete transection of the nerve fiber, is often poor and requires a surgical procedure. Especially for longer gaps (>3 mm), end-to-end suturing of the proximal to the distal part is not possible, …