Srinivas Nallandhighal
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View article: Molecular Profiling of Primary versus Paired Asynchronous Metastatic Clear Cell Renal Cell Carcinoma Reveals Heterogeneity in Tumor Immune Microenvironment
Molecular Profiling of Primary versus Paired Asynchronous Metastatic Clear Cell Renal Cell Carcinoma Reveals Heterogeneity in Tumor Immune Microenvironment Open
View article: Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma
Spatial analysis reveals a novel inflammatory tumor transition state which promotes a macrophage-driven induction of sarcomatoid renal cell carcinoma Open
SUMMARY Sarcomatoid renal cell carcinoma (sRCC) is an aggressive transdifferentiation of epithelioid clear cell RCC (ccRCC) tumors that shows heightened response to immunotherapy. The underlying biology leading to sarcomatoid transformatio…
View article: Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis
Integrative multi-region molecular profiling of primary prostate cancer in men with synchronous lymph node metastasis Open
Localized prostate cancer is frequently composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing clones that may drive the biologi…
View article: Discovery and Validation of a 15-Gene Prognostic Signature for Clear Cell Renal Cell Carcinoma
Discovery and Validation of a 15-Gene Prognostic Signature for Clear Cell Renal Cell Carcinoma Open
PURPOSE Develop and validate gene expression–based biomarker associated with recurrent disease to facilitate risk stratification of clear cell renal cell carcinoma (ccRCC). MATERIALS AND METHODS We retrospectively identified 110 patients w…
View article: Analysis of the Tumor Immune Microenvironment (TIME) in Clear Cell Renal Cell Carcinoma (ccRCC) Reveals an M0 Macrophage-Enriched Subtype: An Exploration of Prognostic and Biological Characteristics of This Immune Phenotype
Analysis of the Tumor Immune Microenvironment (TIME) in Clear Cell Renal Cell Carcinoma (ccRCC) Reveals an M0 Macrophage-Enriched Subtype: An Exploration of Prognostic and Biological Characteristics of This Immune Phenotype Open
There is a need to optimize the treatment of clear cell renal cell carcinoma (ccRCC) patients at high recurrence risk after nephrectomy. We sought to elucidate the tumor immune microenvironment (TIME) of localized ccRCC and understand the …
View article: Role of Adenosine Deaminase in Prostate Cancer Progression
Role of Adenosine Deaminase in Prostate Cancer Progression Open
Prostate cancer (PCa) is the second most common cancer and constitutes about 14.7% of total cancer cases. PCa is highly prevalent and more aggressive in African American (AA) men when compared to European-American (EA) men. PCa tends to be…
View article: Integrative multi-region molecular profiling of primary prostate cancer with synchronous lymph node metastasis to characterize the biologically dominant clone
Integrative multi-region molecular profiling of primary prostate cancer with synchronous lymph node metastasis to characterize the biologically dominant clone Open
Localized prostate cancer is composed of multiple spatially distinct tumors with significant inter- and intra-tumoral molecular heterogeneity. This genomic diversity gives rise to many competing subclones that may drive the biological traj…
View article: Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC) Open
The substantial biological heterogeneity of metastatic prostate cancer has hindered the development of personalized therapeutic approaches. Therefore, it is difficult to predict the course of metastatic hormone-sensitive prostate cancer (m…
View article: The prevalence and density of asymptomatic Plasmodium falciparum infections among children and adults in three communities of western Kenya
The prevalence and density of asymptomatic Plasmodium falciparum infections among children and adults in three communities of western Kenya Open
View article: MP60-05 MOLECULAR PROFILING OF PROSTATE CANCER REVEALS INCREASED INFLAMMATORY MARKERS AND POOR CLINICAL OUTCOMES IN AFRICAN AMERICAN COMPARED TO EUROPEAN AMERICAN MEN
MP60-05 MOLECULAR PROFILING OF PROSTATE CANCER REVEALS INCREASED INFLAMMATORY MARKERS AND POOR CLINICAL OUTCOMES IN AFRICAN AMERICAN COMPARED TO EUROPEAN AMERICAN MEN Open
You have accessJournal of UrologyProstate Cancer: Markers (MP60)1 Sep 2021MP60-05 MOLECULAR PROFILING OF PROSTATE CANCER REVEALS INCREASED INFLAMMATORY MARKERS AND POOR CLINICAL OUTCOMES IN AFRICAN AMERICAN COMPARED TO EUROPEAN AMERICAN ME…
View article: The prevalence and density of asymptomatic <i>Plasmodium falciparum</i> infections among children and adults in three communities of western Kenya
The prevalence and density of asymptomatic <i>Plasmodium falciparum</i> infections among children and adults in three communities of western Kenya Open
Background Further reductions in malaria incidence as more countries approach malaria elimination require the identification and treatment of asymptomatic individuals who carry mosquito-infective Plasmodium gametocytes that are responsible…
View article: Development of a Whole-urine, Multiplexed, Next-generation RNA-sequencing Assay for Early Detection of Aggressive Prostate Cancer
Development of a Whole-urine, Multiplexed, Next-generation RNA-sequencing Assay for Early Detection of Aggressive Prostate Cancer Open
View article: Determining the prevalence and density of asymptomatic Plasmodium falciparum infections in low and high transmission settings in Western Kenya
Determining the prevalence and density of asymptomatic Plasmodium falciparum infections in low and high transmission settings in Western Kenya Open
Background/Objective: Malaria remains a global health burden as 2018 saw 228 million cases worldwide. Pre-elimination efforts aim to decrease disease transmission, which depends on development of asexual parasites to sexual gametocytes wit…
View article: Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors
Platelet PD-L1 suppresses anti-cancer immune cell activity in PD-L1 negative tumors Open
Strategies that interfere with the binding of the receptor programmed cell death protein-1 (PD-1) to programmed death ligand-1 (PD-L1) have shown marked efficacy against many advanced cancers, including those that are negative for PD-L1. P…
View article: Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study
Serial Molecular Profiling of Low-grade Prostate Cancer to Assess Tumor Upgrading: A Longitudinal Cohort Study Open
View article: MP51-03 PROSTATE TUMOR SIZE IS INDEPENDENTLY ASSOCIATED WITH GENOMIC RISK
MP51-03 PROSTATE TUMOR SIZE IS INDEPENDENTLY ASSOCIATED WITH GENOMIC RISK Open
You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (MP51)1 Apr 2020MP51-03 PROSTATE TUMOR SIZE IS INDEPENDENTLY ASSOCIATED WITH GENOMIC RISK Christopher Gaffney*, Deli Liu, Cynthia Angulo, Peter Cai, Simp…
View article: Biologic Significance of Magnetic Resonance Imaging Invisibility in Localized Prostate Cancer
Biologic Significance of Magnetic Resonance Imaging Invisibility in Localized Prostate Cancer Open
PURPOSE Multiparametric magnetic resonance imaging (mpMRI) is used widely for prostate cancer (PCa) evaluation. Approximately 35% of aggressive tumors, however, are not visible on mpMRI. We sought to identify the molecular alterations asso…
View article: Reply to Liu et al
Reply to Liu et al Open
View article: 963. Whole Blood Transcriptome Analysis Reveals Differences in Erythropoiesis and Neurologically Relevant Pathways Between Cerebral Malaria and Severe Malarial Anemia
963. Whole Blood Transcriptome Analysis Reveals Differences in Erythropoiesis and Neurologically Relevant Pathways Between Cerebral Malaria and Severe Malarial Anemia Open
Background Plasmodium falciparum malaria can rapidly progress to severe disease that can lead to death if left untreated. Severe malaria cases commonly present as severe malarial anemia (SMA), defined in children as hemoglobin (Hb) <5 g…
View article: Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages
Coxiella burnetii Blocks Intracellular Interleukin-17 Signaling in Macrophages Open
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella type IVB secretion system (T4BSS), which translocates bacterial effector proteins across th…
View article: <i>Coxiella burnetii</i>blocks intracellular IL-17 signaling in macrophages
<i>Coxiella burnetii</i>blocks intracellular IL-17 signaling in macrophages Open
Coxiella burnetii is an obligate intracellular bacterium and the etiological agent of Q fever. Successful host cell infection requires the Coxiella Type IVB Secretion System (T4BSS), which translocates bacterial effector proteins across th…