Srinivas Nanduri
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View article: OR24-08 A Universally Accessible, Computationally Efficient, Artificial Intelligence Powered Application for Diagnosing Endocrine Cancers
OR24-08 A Universally Accessible, Computationally Efficient, Artificial Intelligence Powered Application for Diagnosing Endocrine Cancers Open
Disclosure: R. Elangovan: None. K. Elangovan: None. J.R. Sethuraj: None. E. Krishnan: None. G. Palaniswamy: None. S. Nanduri: None. K. Sakalabaktula: None. U. Qureshi: None. F. Rahman: None. Z. Baloch: None. Z. Ahmed: None. S. Biswas: None…
View article: A Case Series of Hypermucoid Klebsiella pneumoniae Liver Abscess in Caucasian Americans Without Travel History: An Epidemiologic Shift?
A Case Series of Hypermucoid Klebsiella pneumoniae Liver Abscess in Caucasian Americans Without Travel History: An Epidemiologic Shift? Open
View article: Novel 3,19-(N-Phenyl-3-(4-fluorophenyl)-pyrazole) Acetal of Andrographolide Promotes Cell Cycle Arrest and Apoptosis in MDA-MB-231 Breast Cancer Cells
Novel 3,19-(N-Phenyl-3-(4-fluorophenyl)-pyrazole) Acetal of Andrographolide Promotes Cell Cycle Arrest and Apoptosis in MDA-MB-231 Breast Cancer Cells Open
Background: Natural products play a crucial role in cancer treatment due to their ability to selectively target cancer cells. Andrographolide, a major constituent of Andrographis paniculata, exhibits potential anticancer properties. Consid…
View article: Assessing the Safety of Semaglutide and Tirzepatide in Black and Asian Populations: A Narrative Review
Assessing the Safety of Semaglutide and Tirzepatide in Black and Asian Populations: A Narrative Review Open
View article: Novel 3,19‐(N‐phenyl‐3‐(4‐fluorophenyl)‐pyrazole) Acetal of Andrographolide Promotes Cell Cycle Arrest and Apoptosis in MDA‐MB‐231 Breast Cancer Cells
Novel 3,19‐(N‐phenyl‐3‐(4‐fluorophenyl)‐pyrazole) Acetal of Andrographolide Promotes Cell Cycle Arrest and Apoptosis in MDA‐MB‐231 Breast Cancer Cells Open
Natural products have been crucial in cancer treatment due to their ability to selectively target cancer cells. Andrographolide, a major bioactive compound from the plant Andrographis paniculata, and its derivatives exhibited potential ant…
View article: Promising New Anti‐<scp>TIGIT</scp> Agents: Stealthy Allies in Cancer Immunotherapy
Promising New Anti‐<span>TIGIT</span> Agents: Stealthy Allies in Cancer Immunotherapy Open
TIGIT (T cell immunoreceptor with immunoglobulin and tyrosine‐based inhibitory motif (ITIM) domain), Vstm3, and VSIG9, are newly recognized immunological checkpoints. They are prominently expressed on CD4+ and CD8+ T cells, tumor‐infiltrat…
View article: Exploration of Benzofuran/Indole‐Chalcone Conjugated 1,2,3‐Triazole Hybrids as <i>Candida glabrata</i> Agents: Design, Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Analysis
Exploration of Benzofuran/Indole‐Chalcone Conjugated 1,2,3‐Triazole Hybrids as <i>Candida glabrata</i> Agents: Design, Synthesis, Biological Evaluation, Molecular Docking, and In Silico ADMET Analysis Open
A novel series of benzofuran/indole‐chalcone linked 1,2,3‐triazole hybrids ( 4a–k , 8a–h ) were synthesized to explore their potential as antifungal agents. Among the 19 derivatives, 4b , 4c , 4i , 4j , and 8a showed inhibition against Can…
View article: Novel Imidazopyridine Derivatives Targeting Cytochrome bd Oxidase: A Promising Strategy to Combat Tuberculosis
Novel Imidazopyridine Derivatives Targeting Cytochrome bd Oxidase: A Promising Strategy to Combat Tuberculosis Open
Tuberculosis (TB) treatment is time-consuming and is further worsened due to multi-drug resistance and toxicities. Hence, there is a need for the discovery of newer antituberculosis drugs. One of the important and emerging areas of discove…
View article: Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against <i>Staphylococcus aureus</i>
Design, synthesis, and biological evaluation of pyrazole–ciprofloxacin hybrids as antibacterial and antibiofilm agents against <i>Staphylococcus aureus</i> Open
A series of pyrazole–ciprofloxacin hybrids were designed, synthesized, and tested for antibacterial activity against Staphylococcus aureus , Pseudomonas aeruginosa , and Mycobacterium tuberculosis , aiming to combat antibiotic resistance.
View article: Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>
Synthesis and biological evaluation of new naphthalimide–thiourea derivatives as potent antimicrobial agents active against multidrug-resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i> Open
Novel series of naphthalimide thiourea derivatives were synthesised and evaluated against bacterial pathogen panel and mycobacterial pathogen panel.
View article: Synthesis of novel pyrazole acetals of andrographolide and isoandrographolide as potent anticancer agents
Synthesis of novel pyrazole acetals of andrographolide and isoandrographolide as potent anticancer agents Open
Synthesis, characterization of pyrazole acetals of andrographolide and their in vitro anticancer activity.
View article: Development of naphthalimide hydrazide derivatives as potent antibacterial agents against carbapenem-resistant <i>A. baumannii</i>
Development of naphthalimide hydrazide derivatives as potent antibacterial agents against carbapenem-resistant <i>A. baumannii</i> Open
Novel naphthalimide hydrazide derivatives were synthesised and evaluated against carbapenem-resistant A. baumannii .
View article: Oxiconazole Potentiates Gentamicin against Gentamicin-Resistant Staphylococcus aureus <i>In Vitro</i> and <i>In Vivo</i>
Oxiconazole Potentiates Gentamicin against Gentamicin-Resistant Staphylococcus aureus <i>In Vitro</i> and <i>In Vivo</i> Open
Staphylococcus aureus , which causes the majority of nosocomial and community-acquired infections globally, is a WHO high-priority pathogen for antibiotic research and development. In addition to invasive infections, it is the causative ag…
View article: Design, synthesis, and structure–activity studies of new rhodanine derivatives as carbonic anhydrase II, IX inhibitors
Design, synthesis, and structure–activity studies of new rhodanine derivatives as carbonic anhydrase II, IX inhibitors Open
Rhodanine and its derivatives are an important class of heterocycles with diverse biological properties, including anticancer, antibacterial, and anti‐mycobacterial activities. In the present work, four series of new Rhodanine derivatives …
View article: CCDC 2156073: Experimental Crystal Structure Determination
CCDC 2156073: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Data from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Data from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity Open
Alterations in the gene encoding for the FGFR and upregulation of the VEGFR are found often in cancer, which correlate with disease progression and unfavorable survival. In addition, FGFR and VEGFR signaling synergistically promote tumor a…
View article: Supplementary Table S1 and Figures S1-S7 from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Supplementary Table S1 and Figures S1-S7 from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity Open
Supplementary table S1 shows the effect of ODM-203 in a large kinase panel. Supplementary figure S1 shows how ODM-203 is synthesized. Supplementary figure S2 shows the effect of ODM-203 on FRS2 phosphorylation. Supplement figure S3 shows t…
View article: Supplementary Table S1 and Figures S1-S7 from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Supplementary Table S1 and Figures S1-S7 from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity Open
Supplementary table S1 shows the effect of ODM-203 in a large kinase panel. Supplementary figure S1 shows how ODM-203 is synthesized. Supplementary figure S2 shows the effect of ODM-203 on FRS2 phosphorylation. Supplement figure S3 shows t…
View article: Data from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity
Data from ODM-203, a Selective Inhibitor of FGFR and VEGFR, Shows Strong Antitumor Activity, and Induces Antitumor Immunity Open
Alterations in the gene encoding for the FGFR and upregulation of the VEGFR are found often in cancer, which correlate with disease progression and unfavorable survival. In addition, FGFR and VEGFR signaling synergistically promote tumor a…
View article: CCDC 2203808: Experimental Crystal Structure Determination
CCDC 2203808: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII
Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII Open
The Carbonic anhydrase isoforms IX and XII play a significant role in regulating the intracellular and extracellular pH in hypoxic tumours abetting the metastasis of solid tumours. Selective and potent inhibitors targeting carbonic anhydra…
View article: Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i>
Synthesis and pharmacological evaluation of 1,3-diaryl substituted pyrazole based (thio)urea derivatives as potent antimicrobial agents against multi-drug resistant <i>Staphylococcus aureus</i> and <i>Mycobacterium tuberculosis</i> Open
One lead compound, 7a, (3,4-dichlorophenyl derivative), exhibited potent activity against S. aureus (MIC = 0.25 μg mL −1 ), and the other compound, 7j (2,4-difluorophenyl derivative) against Mycobacterium tuberculosis (MIC = 1 μg mL −1 ) w…
View article: Isoxazole carboxylic acid methyl ester-based urea and thiourea derivatives as promising antitubercular agents
Isoxazole carboxylic acid methyl ester-based urea and thiourea derivatives as promising antitubercular agents Open
View article: CCDC 2117832: Experimental Crystal Structure Determination
CCDC 2117832: Experimental Crystal Structure Determination Open
View article: Synthesis and evaluation of triazole congeners of nitro-benzothiazinones potentially active against drug resistant <i>Mycobacterium tuberculosis</i> demonstrating bactericidal efficacy
Synthesis and evaluation of triazole congeners of nitro-benzothiazinones potentially active against drug resistant <i>Mycobacterium tuberculosis</i> demonstrating bactericidal efficacy Open
Lead compound was identified to be a selective inhibitor of Mtb H37Rv with no appreciable cytotoxicity, demonstrating quite comparable bactericidal efficacy to RIF.
View article: Anti-cancer activity of heteroaromatic acetals of andrographolide and its isomers
Anti-cancer activity of heteroaromatic acetals of andrographolide and its isomers Open
Derivatives of andrographolide were screened for their anti-cancer potency against breast cancer MDA-MB-231 and their mechanism of action was further evaluated.
View article: CCDC 2080295: Experimental Crystal Structure Determination
CCDC 2080295: Experimental Crystal Structure Determination Open
View article: CCDC 2067730: Experimental Crystal Structure Determination
CCDC 2067730: Experimental Crystal Structure Determination Open
View article: CCDC 2067731: Experimental Crystal Structure Determination
CCDC 2067731: Experimental Crystal Structure Determination Open
View article: Fused-azepinones: Emerging scaffolds of medicinal importance
Fused-azepinones: Emerging scaffolds of medicinal importance Open