Srinivasa T. Reddy
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View article: Ultrafine particulate matter exposure induces gut microbiota dysbiosis together with ER stress in the liver and worsened atherosclerosis
Ultrafine particulate matter exposure induces gut microbiota dysbiosis together with ER stress in the liver and worsened atherosclerosis Open
View article: Nipah Virus Outbreaks in India: A Comprehensive Update
Nipah Virus Outbreaks in India: A Comprehensive Update Open
View article: Differential ABA sensitivity of superior and inferior rice grains is linked to cell cycle entry into endoreduplication
Differential ABA sensitivity of superior and inferior rice grains is linked to cell cycle entry into endoreduplication Open
Suboptimal grain filling in rice ( Oryza sativa ) inferior spikelets poses a constraint to maximizing the yield potential. The differential grain filling between superior and inferior spikelets has been primarily attributed to differences …
View article: Mechanisms and applications of apolipoproteins and apolipoprotein mimetic peptides: Common pathways in cardiovascular disease and cancer
Mechanisms and applications of apolipoproteins and apolipoprotein mimetic peptides: Common pathways in cardiovascular disease and cancer Open
Apolipoproteins are the defining functional component of lipoproteins and play critical roles in lipid transport and metabolism. High-density lipoprotein (HDL) and its primary functional constituent, apolipoprotein A-I, are of particular i…
View article: Abstract 1746 Evolution of substrate specificity among short chain fatty acid (SCFA) kinases of the gut microbiome
Abstract 1746 Evolution of substrate specificity among short chain fatty acid (SCFA) kinases of the gut microbiome Open
View article: Identifying a Sepsis Subphenotype Characterized by Dysregulated Lipoprotein Metabolism Using a Simplified Clinical Data Algorithm
Identifying a Sepsis Subphenotype Characterized by Dysregulated Lipoprotein Metabolism Using a Simplified Clinical Data Algorithm Open
Background Cholesterol metabolism is dysregulated in sepsis contributing to patient heterogeneity. Subphenotypes displaying lower lipoprotein levels and higher mortality (HYPO) or higher lipoprotein levels and lower mortality (NORMO), were…
View article: Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity
Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity Open
Objective To evaluate circulating levels of intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) in patients with dermatomyositis (DM) and DM associated interstitial lung disease (DM-ILD). Methods We …
View article: A Novel Application of Lc-Ms/Ms Accurately Quantifies the Labile Redox Pools of Cellular Coenzymes Q9 and Q10
A Novel Application of Lc-Ms/Ms Accurately Quantifies the Labile Redox Pools of Cellular Coenzymes Q9 and Q10 Open
View article: Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer
Prostaglandin E2 and Akt Promote Stemness in Apc Mutant Dclk1+ Cells to Give Rise to Colitis-associated Cancer Open
Our data shows that epithelial and Dclk1+ cell-derived COX-1 plays an important role in inflammation-associated tumorigenesis. Importantly, low-dose aspirin was effective in chemo-prevention through inhibition of COX-1 that reduced colitis…
View article: Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality
Multiomic molecular patterns of lipid dysregulation in a subphenotype of sepsis with higher shock incidence and mortality Open
Background Lipids play a critical role in defense against sepsis. We sought to investigate gene expression and lipidomic patterns of lipid dysregulation in sepsis. Methods Data from four adult sepsis studies were analyzed and findings were…
View article: Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension
Intestinal IFNα4 promotes 15-HETE diet-induced pulmonary hypertension Open
Objectives Pulmonary arterial hypertension (PAH) is characterized by the remodeling of the pulmonary vascular bed leading to elevation of the pulmonary arterial pressure. Oxidized fatty acids, such as hydroxyeicosatetraenoic acids (HETEs),…
View article: Disease response in rheumatoid arthritis across four biologic therapies associates with improvement in paraoxonase-1 activity and oxylipins
Disease response in rheumatoid arthritis across four biologic therapies associates with improvement in paraoxonase-1 activity and oxylipins Open
Objective Paraoxonase-1 (PON1) is a high-density lipoprotein (HDL)-associated enzyme, that has been implicated as a biomarker of cardiovascular risk in patients with rheumatoid arthritis (RA). We aimed to investigate how different biologic…
View article: Mass spectrometric profiling of estrogen and estrogen metabolites in human stool and plasma partially elucidates the role of the gut microbiome in estrogen recycling
Mass spectrometric profiling of estrogen and estrogen metabolites in human stool and plasma partially elucidates the role of the gut microbiome in estrogen recycling Open
Estrogen and estrogen metabolites are commonly measured in human plasma and serum, but there exist almost no reports of estrogen measured in human stool. This methodological limitation in turn limits our understanding of the relationship b…
View article: Evidence further linking the intestine to cardiovascular disease
Evidence further linking the intestine to cardiovascular disease Open
Purpose of review To review recent publications linking the intestine to cardiovascular disease. Recent findings Aromatic amino acid-derived metabolites produced by gut-bacteria were identified that increased or decreased the risk of cardi…
View article: Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid
Ambient Particulate Matter Induces In Vitro Toxicity to Intestinal Epithelial Cells without Exacerbating Acute Colitis Induced by Dextran Sodium Sulfate or 2,4,6-Trinitrobenzenesulfonic Acid Open
Inflammatory bowel disease (IBD) is an immunologically complex disorder involving genetic, microbial, and environmental risk factors. Its global burden has continued to rise since industrialization, with epidemiological studies suggesting …
View article: Non‐Invasive Detection of Early‐Stage Fatty Liver Disease via an On‐Skin Impedance Sensor and Attention‐Based Deep Learning
Non‐Invasive Detection of Early‐Stage Fatty Liver Disease via an On‐Skin Impedance Sensor and Attention‐Based Deep Learning Open
Early‐stage nonalcoholic fatty liver disease (NAFLD) is a silent condition, with most cases going undiagnosed, potentially progressing to liver cirrhosis and cancer. A non‐invasive and cost‐effective detection method for early‐stage NAFLD …
View article: Lipidomic changes in a novel sepsis <scp>outcome‐based</scp> analysis reveals potent <scp>pro‐inflammatory</scp> and <scp>pro‐resolving</scp> signaling lipids
Lipidomic changes in a novel sepsis <span>outcome‐based</span> analysis reveals potent <span>pro‐inflammatory</span> and <span>pro‐resolving</span> signaling lipids Open
The purpose of this study was to investigate changes in the lipidome of patients with sepsis to identify signaling lipids associated with poor outcomes that could be linked to future therapies. Adult patients with sepsis were enrolled with…
View article: Abstract 2037 The Role of Intestinal ApoA-I in Mouse Models of Diet-Induced Inflammation and Atherosclerosis
Abstract 2037 The Role of Intestinal ApoA-I in Mouse Models of Diet-Induced Inflammation and Atherosclerosis Open
Introduction: Systemic inflammation is a major underlying risk factor for the development of atherosclerosis. The inflammatory condition is often initiated or exacerbated by a western-style diet (WD) high in calories and fats. To mitigate …
View article: Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites
Exercise mitigates flow recirculation and activates metabolic transducer SCD1 to catalyze vascular protective metabolites Open
Exercise promotes pulsatile shear stress in the arterial circulation and ameliorates cardiometabolic diseases. However, exercise-mediated metabolic transducers for vascular protection remain under-investigated. Untargeted metabolomic analy…
View article: 48P BWC5044 is a novel potent and highly selective CDK7 inhibitor that suppresses transcriptional activity and arrests the cell cycle through MYC
48P BWC5044 is a novel potent and highly selective CDK7 inhibitor that suppresses transcriptional activity and arrests the cell cycle through MYC Open
Cyclin-dependent kinase 7 (CDK7) has emerged as an exciting target for oncotherapy because it controls both the cell cycle and RNA Pol II-mediated transcription, two critical processes dysregulated in cancer cells. Here, we report the disc…
View article: 47P Unlocking potential for enhancing anti-tumor immunity: Targeting hematopoietic progenitor kinase 1 (HPK1) with novel small molecules
47P Unlocking potential for enhancing anti-tumor immunity: Targeting hematopoietic progenitor kinase 1 (HPK1) with novel small molecules Open
HPK1, a MAP4K family serine/threonine kinase exclusive to hematopoietic cells, plays a pivotal role in dampening TCR and BCR signal cascades. Its functions extend to influencing IL2 secretion, T-cell maturation and migration, tumor infiltr…
View article: Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models
Subchronic inhalation exposure to ultrafine particulate matter alters the intestinal microbiome in various mouse models Open
View article: TRENDS IN CHOLESTEROL AND LIPOPROTEINS ARE ASSOCIATED WITH ACUTE RESPIRATORY DISTRESS SYNDROME INCIDENCE AND DEATH AMONG SEPSIS PATIENTS
TRENDS IN CHOLESTEROL AND LIPOPROTEINS ARE ASSOCIATED WITH ACUTE RESPIRATORY DISTRESS SYNDROME INCIDENCE AND DEATH AMONG SEPSIS PATIENTS Open
Objective: Compare changes in cholesterol and lipoprotein levels occurring in septic patients with and without acute respiratory distress syndrome (ARDS) and by survivorship. Methods: We reanalyzed data from prospective sepsis studies. Cho…
View article: 152P Discovery of best-in-class dual-acting A2AR/A2BR antagonists that are functional in high adenosine environment
152P Discovery of best-in-class dual-acting A2AR/A2BR antagonists that are functional in high adenosine environment Open
Adenosine accumulates in the tumor microenvironment due to abnormal tumor metabolism and hypoxia. It binds to A2A and A2B receptors on immune cells and impairs their activation and cytotoxic ability, helping cancers to evade the immune sys…
View article: Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice
Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice Open
Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant …
View article: Correction to: Suppressed paraoxonase-1 activity associates with elevated oxylipins and the presence of small airways disease in patients with rheumatoid arthritis
Correction to: Suppressed paraoxonase-1 activity associates with elevated oxylipins and the presence of small airways disease in patients with rheumatoid arthritis Open
View article: Lipid Mediators and Cytokines/Chemokines Display Differential Profiles in Severe versus Mild/Moderate COVID-19 Patients
Lipid Mediators and Cytokines/Chemokines Display Differential Profiles in Severe versus Mild/Moderate COVID-19 Patients Open
Host immune responses play a key role in COVID-19 pathogenesis. The underlying phenomena are orchestrated by signaling molecules such as cytokines/chemokines and lipid mediators. These immune molecules, including anti-SARS-CoV-2 antibodies…
View article: Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity
Integrating 4-D light-sheet fluorescence microscopy and genetic zebrafish system to investigate ambient pollutants-mediated toxicity Open
View article: The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis
The multiple roles of lysophosphatidic acid in vascular disease and atherosclerosis Open
Purpose of review To explore the multiple roles that lysophosphatidic acid (LPA) plays in vascular disease and atherosclerosis. Recent findings A high-fat high-cholesterol diet decreases antimicrobial activity in the small intestine, which…
View article: Stability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide
Stability Characterization of the Novel Anti-Cancer HM-10/10 HDL-Mimetic Peptide Open
Epithelial adenocarcinoma of the ovary and colon are associated with the highest rates of cancer-related deaths in women in the U.S. The literature supports the role of HDL-associated apolipoproteins in the treatment of cancer and other pr…