Srona Sengupta
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View article: A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice
A TCR-mimic bispecific antibody reduces HIV-1 provirus and delays viral rebound in HLA-matched humanized mice Open
Bispecific antibodies that reroute cytotoxic effectors toward infected cells are promising HIV-1 cure agents, yet existing formats bind Env and are limited by antigenic variation and Env down-regulation. We engineered a TCR-mimic single-ch…
View article: Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells
Bispecific antibodies promote natural killer cell-mediated elimination of HIV-1 reservoir cells Open
View article: A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design
A cell-free antigen processing system informs HIV-1 epitope selection and vaccine design Open
Distinct CD4+ T cell epitopes have been associated with spontaneous control of HIV-1 replication, but analysis of antigen-dependent factors that influence epitope selection is lacking. To examine these factors, we used a cell-free antigen …
View article: Persistent CAD activity in memory CD8 <sup>+</sup> T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
Persistent CAD activity in memory CD8 <sup>+</sup> T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge Open
Memory CD8 + T cells are characterized by their ability to persist long after the initial antigen encounter and their capacity to generate a rapid recall response. Recent studies have identified a role for metabolic reprogramming and mitoc…
View article: TCR-mimic bispecific antibodies to target the HIV-1 reservoir
TCR-mimic bispecific antibodies to target the HIV-1 reservoir Open
Significance Novel approaches to promote killing of HIV-1–infected cells are necessary for elimination of the latent reservoir, the main barrier to a cure. Here, we utilized a diverse phage-display library to construct T cell receptor (TCR…
View article: Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge
Persistent CAD activity in memory CD8+ T cells supports rRNA synthesis and ribosomal biogenesis required at rechallenge Open
Memory CD8+ T cells are characterized by their ability to persist long after the initial antigen encounter and their ability to generate a rapid recall response. Recent studies have identified a role for metabolic reprogramming and mitocho…
View article: A Cell-Free Antigen Processing System Reveals Factors Critical for HIV-1 Epitope Dominance and Informs Vaccine Design
A Cell-Free Antigen Processing System Reveals Factors Critical for HIV-1 Epitope Dominance and Informs Vaccine Design Open
View article: Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence
Multiple genetic programs contribute to CD4 T cell memory differentiation and longevity by maintaining T cell quiescence Open
View article: Different human resting memory CD4 <sup>+</sup> T cell subsets show similar low inducibility of latent HIV-1 proviruses
Different human resting memory CD4 <sup>+</sup> T cell subsets show similar low inducibility of latent HIV-1 proviruses Open
Latent replication-competent HIV-1 proviruses in different memory T cell subsets show no differences in viral gene transcription after T cell activation.
View article: A quantitative approach for measuring the reservoir of latent HIV-1 proviruses
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses Open
View article: Targeting the Latent Reservoir for HIV-1
Targeting the Latent Reservoir for HIV-1 Open
View article: Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls
Infection and characterization of Toxoplasma gondii in human induced neurons from patients with brain disorders and healthy controls Open
View article: Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities
Enhanced conversion of induced neuronal cells (iN cells) from human fibroblasts: Utility in uncovering cellular deficits in mental illness-associated chromosomal abnormalities Open