Explanipedia

PREDICT-ITB: Predicting response in children with dystonic CP to ITB – study protocol Open

Sruthi P. Thomas, Darcy Fehlings, Sharon Landesman Ramey, Mark R. Conaway, Steven Kralik , et al. · 2025

Introduction Over 11,000 infants are diagnosed with cerebral palsy (CP) each year, with lifetime medical costs exceeding $1.4 million per person. Elevated muscle tone in CP, including dystonia and spasticity, significantly impairs function…

Showcasing the breadth of pediatric rehabilitation medicine Open

Rachel Byrne, Heakyung Kim, Raffi Najarian, Elaine Pico, Justin Ramsey , et al. · 2025

Sensory Symptoms Across the Lifespan in People With Cerebral Palsy Open

Ariel M. Lyons‐Warren, Danielle Guez‐Barber, Sruthi P. Thomas, Evelyne K. Tantry, Aditya Mahat , et al. · 2024

The critical need to accelerate cerebral palsy research with consumer engagement, global networks, and adaptive designs Open

Sruthi P. Thomas, Iona Novak, Anina Ritterband‐Rosenbaum, Karin Lind, Annabel Webb , et al. · 2024

The prevalence of cerebral palsy (CP) varies globally, with higher rates and burden of disease in low- and middle-income countries. CP is a lifelong condition with no cure, presenting diverse challenges such as motor impairment, epilepsy, …

Physician Approaches to the Pharmacologic Treatment of Dystonia in Cerebral Palsy Open

Emma Lott, Darcy Fehlings, Rose Gelineau‐Morel, Michael C. Kruer, Jonathan W. Mink , et al. · 2024

Objective To determine how physicians approach pharmacologic dystonia treatment in people with CP and assess physician readiness to participate in a randomized trial comparing existing pharmacologic dystonia treatments. Methods We administ…

Function and dysfunction of the dystonia network: an exploration of neural circuits that underlie the acquired and isolated dystonias Open

Jason S. Gill, Megan X. Nguyen, Mariam Hull, Meike E. van der Heijden, Ken Nguyen , et al. · 2023

Dystonia is a highly prevalent movement disorder that can manifest at any time across the lifespan. An increasing number of investigations have tied this disorder to dysfunction of a broad “dystonia network” encompassing the cerebellum, th…

Sensory symptoms across the lifespan in people with cerebral palsy Open

Ariel M. Lyons‐Warren, Danielle Guez‐Barber, Sruthi P. Thomas, Evelyne K. Tantry, Aditya Mahat , et al. · 2023

Structured Abstract AIM To estimate prevalence of sensory symptoms in people with cerebral palsy (CP) across the lifespan. METHOD In this cross-sectional study, the self-reported Sensory Processing Scale Inventory (SPS-I) was administered …

Cation leak through the ATP1A3 pump causes spasticity and intellectual disability Open

Daniel G. Calame, Cristina Moreno Vadillo, Seth Berger, Timothy Lotze, Marwan Shinawi , et al. · 2023

ATP1A3 encodes the α3 subunit of the sodium-potassium ATPase, one of two isoforms responsible for powering electrochemical gradients in neurons. Heterozygous pathogenic ATP1A3 variants produce several distinct neurological syndromes, yet t…

Pediatric Spina Bifida and Spinal Cord Injury Open

Joslyn Gober, Sruthi P. Thomas, David R. Gater · 2022

Pediatric spina bifida (SB) and spinal cord injury (SCI) are unfortunately common in our society, and their unique findings and comorbidities warrant special consideration. This manuscript will discuss the epidemiology, pathophysiology, pr…

Pharmacologic and Acute Management of Spinal Cord Injury in Adults and Children Open

Ajay X. Thomas, James J. Riviello, Daniel Davila‐Williams, Sruthi P. Thomas, Jennifer Erklauer , et al. · 2022

Purpose of Review This review provides guidance for acute spinal cord injury (SCI) management through an analytical assessment of the most recent evidence on therapies available for treating SCI, including newer therapies under investigati…

Management of severe spasticity with and without dystonia with intrathecal baclofen in the pediatric population: a cross-sectional study Open

Joslyn Gober, Michelle L. Seymour, Hongyu Miao, Daniel J. Curry, Sruthi P. Thomas · 2022

Objective To investigate the differences in delivery mode, daily dose, and catheter tip location in pediatric patients using intrathecal baclofen (ITB) pumps with spasticity plus dystonia versus spasticity alone. Methods A single-center, c…

Urinary catheter use in patients with hip fracture: Are current guidelines appropriate? A retrospective review Open

Sruthi P. Thomas, Nicole Harris, Johanna Dobransky, George Grammatopoulos, Kathleen Gartke , et al. · 2021

Indwelling catheters were used frequently, which suggests low compliance with clinical guidelines. Longer duration of catheter use led to higher rates of UTI and POUR. Further investigation of the reasons for the common use of indwelling r…

Pediatric intrathecal baclofen management during the COVID-19 pandemic in the US and Canada Open

Sruthi P. Thomas, Christina K. Hardesty, Kristin Buxton, Andrew B. Collins, Jessica Pruente , et al. · 2020

The COVID-19 pandemic has been a challenge to healthcare systems around the world. Within pediatric rehabilitation medicine, management of intrathecal baclofen has been particularly challenging. This editorial reviews how programs in the U…

Prevalence of metabolic syndrome and cardiovascular disease risk factors in adults with cerebral palsy Open

Patricia Heyn, Alex Tagawa, Zhaoxing Pan, Sruthi P. Thomas, James Carollo · 2019

Aim To investigate the prevalence of metabolic syndrome and cardiovascular disease ( CVD ) risk factors and the association between common metabolic markers and Gross Motor Function Classification System ( GMFCS ) levels in ambulatory adul…

Effect of Short Term Isometric Handgrip Training on Blood Pressure among Hypertensive Patients in a Selected Community Area at Mangalore Open

Sruthi P. Thomas · 2016

High blood pressure (BP) is a major public health problem in India and its prevalence is rapidly increasing among both urban and rural populations. In fact, hypertension is the most prevalent chronic disease in India. The prevalence of hyp…

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