Stacey A. Lapp
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View article: HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels
HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels Open
Simian immunodeficiency viruses infecting sooty mangabeys (SIVsmm) gave rise to nine groups of human immunodeficiency virus type 2 (HIV-2). Two of these (A and B) spread substantially with an estimated 1–2 million individuals affected. The…
View article: Caveola-vesicle complexes of Plasmodium vivax and Plasmodium cynomolgi: large-scale aggregation and structure of PHIST-positive vesicles in late schizont-infected red blood cells
Caveola-vesicle complexes of Plasmodium vivax and Plasmodium cynomolgi: large-scale aggregation and structure of PHIST-positive vesicles in late schizont-infected red blood cells Open
View article: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques
Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques Open
The continued evolution of SARS-CoV-2 variants capable of subverting vaccine and infection-induced immunity suggests the advantage of a broadly protective vaccine against betacoronaviruses (β-CoVs). Recent studies have isolated monoclonal …
View article: A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques
A Broad Survey and Functional Analysis of Immunoglobulin Loci Variation in Rhesus Macaques Open
Rhesus macaques (RMs) are a vital model for studying human disease and invaluable to pre-clinical vaccine research, particularly for the study of broadly neutralizing antibody responses. Such studies require robust genetic resources for an…
View article: HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels
HIV-2 evades restriction by ZAP through adaptations in the U3 LTR region despite increased CpG levels Open
Simian immunodeficiency viruses infecting sooty mangabeys (SIVsmm) gave rise to nine groups of human immunodeficiency virus type 2 (HIV-2). Two of these (A and B) spread substantially with an estimated 1- 2 million individuals affected. Th…
View article: Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection
Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection Open
Waning immunity and the emergence of immune evasive SARS-CoV-2 variants jeopardize vaccine efficacy leading to breakthrough infections. We have previously shown that innate immune cells play a critical role in controlling SARS-CoV-2. To in…
View article: Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques
Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques Open
The continued evolution of SARS-CoV-2 variants capable of subverting vaccine and infection-induced immunity suggests the advantage of a broadly protective vaccine against betacoronaviruses (beta-CoVs). Recent studies have isolated monoclon…
View article: Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence Open
View article: Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells
Single-cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells Open
Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas in 2016 and is linked to severe neonatal birth defects, including microcephaly and spontaneous abortion. To better understand the host response to ZIK…
View article: Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells
Single cell analysis reveals an antiviral network that controls Zika virus infection in human dendritic cells Open
Summary Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas in 2016 and is linked to severe neonatal birth defects, including microcephaly and spontaneous abortion. To better understand the host respons…
View article: Malaria disrupts the rhesus macaque gut microbiome
Malaria disrupts the rhesus macaque gut microbiome Open
Previous studies have suggested that a relationship exists between severity and transmissibility of malaria and variations in the gut microbiome, yet only limited information exists on the temporal dynamics of the gut microbial community d…
View article: MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques
MaHPIC malaria systems biology data from Plasmodium cynomolgi sporozoite longitudinal infections in macaques Open
View article: An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice
An RSV Live-Attenuated Vaccine Candidate Lacking G Protein Mucin Domains Is Attenuated, Immunogenic, and Effective in Preventing RSV in BALB/c Mice Open
Background Respiratory syncytial virus (RSV) is a leading viral respiratory pathogen in infants. The objective of this study was to generate RSV live-attenuated vaccine (LAV) candidates by removing the G-protein mucin domains to attenuate …
View article: Plasmodium knowlesi Cytoadhesion Involves SICA Variant Proteins
Plasmodium knowlesi Cytoadhesion Involves SICA Variant Proteins Open
Plasmodium knowlesi poses a health threat throughout Southeast Asian communities and currently causes most cases of malaria in Malaysia. This zoonotic parasite species has been studied in Macaca mulatta (rhesus monkeys) as a model for seve…
View article: Serologic and Cytokine Signatures in Children With Multisystem Inflammatory Syndrome and Coronavirus Disease 2019
Serologic and Cytokine Signatures in Children With Multisystem Inflammatory Syndrome and Coronavirus Disease 2019 Open
Background The serologic and cytokine responses of children hospitalized with multisystem inflammatory syndrome (MIS-C) vs coronavirus disease 2019 (COVID-19) are poorly understood. Methods We performed a prospective, multicenter, cross-se…
View article: Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19
Limited induction of SARS-CoV-2–specific T cell responses in children with multisystem inflammatory syndrome compared with COVID-19 Open
Why multisystem inflammatory syndrome in children (MIS-C) develops after SARS-CoV-2 infection in a subset of children is unknown. We hypothesized that aberrant virus-specific T cell responses contribute to MIS-C pathogenesis. We quantified…
View article: Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi
Clinical recovery of Macaca fascicularis infected with Plasmodium knowlesi Open
View article: SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19
SARS-CoV-2 immune repertoire in MIS-C and pediatric COVID-19 Open
View article: Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection
Original antigenic sin responses to Betacoronavirus spike proteins are observed in a mouse model, but are not apparent in children following SARS-CoV-2 infection Open
Background The effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood. Objectives We sought to determine the effects of prior exposure to HCoV Betacorona…
View article: Cerebrospinal fluid cytokine, chemokine, and SARS-CoV-2 antibody profiles in children with neuropsychiatric symptoms associated with COVID-19
Cerebrospinal fluid cytokine, chemokine, and SARS-CoV-2 antibody profiles in children with neuropsychiatric symptoms associated with COVID-19 Open
View article: Clinical recovery of <i>Macaca fascicularis</i> infected with <i>Plasmodium knowlesi</i>
Clinical recovery of <i>Macaca fascicularis</i> infected with <i>Plasmodium knowlesi</i> Open
Background Kra monkeys ( Macaca fascicularis ), a natural host of Plasmodium knowlesi, control parasitaemia caused by this parasite species and escape death without treatment. Knowledge of the disease progression and resilience in kra monk…
View article: Immune responses and therapeutic challenges in paediatric patients with new‐onset acute myeloid leukaemia and concomitant COVID‐19
Immune responses and therapeutic challenges in paediatric patients with new‐onset acute myeloid leukaemia and concomitant COVID‐19 Open
To study the serological responses to COVID-19 infection in paediatric patients with Acute myeloid leukemia (AML) and the impact of chemotherapy on this response.
View article: Altered amino acid profile in patients with SARS-CoV-2 infection
Altered amino acid profile in patients with SARS-CoV-2 infection Open
Low plasma arginine bioavailability has been implicated in endothelial dysfunction and immune dysregulation. The role of arginine in COVID-19 is unknown, but could contribute to cellular damage if low. Our objective was to determine argini…
View article: #52: Clinical Features and Management of Pediatric Patients Presenting with New Onset Acute Leukemia and Concomitant COVID-19
#52: Clinical Features and Management of Pediatric Patients Presenting with New Onset Acute Leukemia and Concomitant COVID-19 Open
Background Infections represent a significant cause of morbidity and mortality in pediatric patients undergoing treatment for hematologic malignancies. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has led to a wor…
View article: Original antigenic sin responses to heterologous <i>Betacoronavirus</i> spike proteins are observed in mice following intramuscular administration, but are not apparent in children following SARS-CoV-2 infection
Original antigenic sin responses to heterologous <i>Betacoronavirus</i> spike proteins are observed in mice following intramuscular administration, but are not apparent in children following SARS-CoV-2 infection Open
Background The effects of pre-existing endemic human coronavirus (HCoV) immunity on SARS-CoV-2 serologic and clinical responses are incompletely understood. Objectives We sought to determine the effects of prior exposure to HCoV Betacorona…
View article: The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein
The development and kinetics of functional antibody-dependent cell-mediated cytotoxicity (ADCC) to SARS-CoV-2 spike protein Open
View article: Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19
Serology in Children with Multisystem Inflammatory Syndrome (MIS-C) associated with COVID-19 Open
Objectives We aimed to measure SARS-CoV-2 serologic responses in children hospitalized with multisystem inflammatory syndrome (MIS-C) compared to COVID-19, Kawasaki Disease (KD) and other hospitalized pediatric controls. Methods From March…
View article: Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes
Humoral immunity prevents clinical malaria during Plasmodium relapses without eliminating gametocytes Open
Plasmodium relapses are attributed to the activation of dormant liver-stage parasites and are responsible for a significant number of recurring malaria blood-stage infections. While characteristic of human infections caused by P. vivax and…
View article: Distinct amino acid and lipid perturbations characterize acute versus chronic malaria
Distinct amino acid and lipid perturbations characterize acute versus chronic malaria Open
Chronic malaria is a major public health problem and significant challenge for disease eradication efforts. Despite its importance, the biological factors underpinning chronic malaria are not fully understood. Recent studies have shown tha…
View article: Comparative 3D genome organization in apicomplexan parasites
Comparative 3D genome organization in apicomplexan parasites Open
The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and has a complex and dynamic relationship with gene expression. In the human malaria parasite Plasmodium falciparum , the clustering of a family of vir…