Stacey A. Missmer
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View article: Availability of region-specific endometriosis care guidance: a global scoping review
Availability of region-specific endometriosis care guidance: a global scoping review Open
View article: MON-160 Prevalence And Correlates Of Polycystic Ovary Syndrome Among Participants Of The Nurses' Health Study II
MON-160 Prevalence And Correlates Of Polycystic Ovary Syndrome Among Participants Of The Nurses' Health Study II Open
Disclosure: M. Kazemi: None. M. Mitsunami: None. S.A. Missmer: None. J.W. Rich-Edwards: None. J.E. Chavarro: None. Background: Estimates of the prevalence of polycystic ovary syndrome (PCOS) and associated comorbidities are limited in larg…
View article: Pelvic Pain Symptoms and Inflammation Among Adolescents and Adults with and Without Endometriosis
Pelvic Pain Symptoms and Inflammation Among Adolescents and Adults with and Without Endometriosis Open
We evaluated inflammatory markers among 389 surgically confirmed endometriosis cases and 505 controls from the Women’s Health Study: From Adolescence to Adulthood (A2A) cohort. Participants reported dysmenorrhea, acyclic pelvic pain, dyspa…
View article: O-248 Association between history of laparoscopically-confirmed endometriosis and cognitive function at middle-age
O-248 Association between history of laparoscopically-confirmed endometriosis and cognitive function at middle-age Open
Study question Is history of laparoscopically-confirmed endometriosis associated with worse cognitive function in middle-aged women? Summary answer History of laparoscopically-confirmed endometriosis is associated with lower cognitive perf…
View article: Mapping sex and gender in the landscape of spinal cord injury research: a bibliometric analysis and research framework
Mapping sex and gender in the landscape of spinal cord injury research: a bibliometric analysis and research framework Open
Study design Bibliometric analysis and conceptual framework. Objectives To provide a framework for prioritizing sex/gender research in the field of spinal cord injury (SCI), which can help inform and develop future research directions bene…
View article: Retrospective Assessment of Endometriosis Pain Over the Life Course: A Reliability Study Within the <scp>ComPaRe</scp> ‐Endometriosis Cohort
Retrospective Assessment of Endometriosis Pain Over the Life Course: A Reliability Study Within the <span>ComPaRe</span> ‐Endometriosis Cohort Open
Background Endometriosis may manifest through various pain symptoms, such as dysmenorrhea, dyspareunia, dyschezia, dysuria and abdominal pain. While retrospective evaluation of these pain symptoms is less expensive and time‐consuming compa…
View article: Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses’ Health Study II
Prospective evaluation of plasma proteins in relation to surgical endometriosis diagnosis in the Nurses’ Health Study II Open
This study was supported by the Department of Defence, the 2017 Boston Center for Endometriosis Trainee Award. Investigators were supported by Aspira Women's Health and NIH which were not directly related to this project.
View article: Acute serum androgen levels and post-rehabilitation functioning in spinal cord injury: findings from SwiSCI
Acute serum androgen levels and post-rehabilitation functioning in spinal cord injury: findings from SwiSCI Open
Our results underscore the potential role of early androgen assessment and modulation in optimizing rehabilitation outcomes in males with SCI.
View article: Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study
Exploring the value of a well-established conditioned pain modulation paradigm in women: a Translational Research in Pelvic Pain (TRiPP) study Open
Background Conditioned pain modulation (CPM) is considered a human proxy for descending inhibitory pain pathways. However, there is wide variation in the CPM response described in the literature and ongoing debate about its utility. Method…
View article: Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis
Non-malignant gynaecological disease and risk of cardiovascular or cerebrovascular disease: a systematic review and meta-analysis Open
Background Cardiovascular disease is the leading cause of death globally. Non-malignant gynaecological diseases (NMGD) significantly affect patient health and well-being and may be associated with cardiovascular or cerebrovascular disease …
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Organoids): endometrial organoids as an emerging technology for endometriosis research Open
The aetiology of endometriosis remains poorly understood. In vitro model systems provide the opportunity to identify the mechanisms driving disease pathogenesis using human cells. Three-dimensional models, particularly organoid systems, ha…
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Heterologous): heterologous rodent models Open
Endometriosis, defined as the growth of endometrial-like tissues outside the uterus, is a common disease among women. Numerous in vivo rodent models of endometriosis have been developed to explore multiple aspects of this poorly understood…
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Homologous): homologous rodent models Open
In vivo models of endometriosis enable the discovery and preclinical testing of new therapies. Several rodent models of endometriosis exist, but a lack of harmonization impedes reproducibility and comparability of results among investigato…
View article: WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis
WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis Open
Pain is a debilitating symptom of endometriosis, and its mechanisms are often explored using rodent models. However, a lack of harmonization amongst models and behavioural measures, in addition to inconsistent reporting, might limit the ov…
View article: Translation, cross-cultural adaptation into Brazilian Portuguese and electronic migration of the WERF EPHect endometriosis patient questionnaire
Translation, cross-cultural adaptation into Brazilian Portuguese and electronic migration of the WERF EPHect endometriosis patient questionnaire Open
This study successfully translated, adapted, and migrated the WERF EPHect EPQ-S into Brazilian Portuguese using REDCap. The findings underscore the linguistic and cultural challenges of such adaptations and highlight the electronic version…
View article: Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study
Endometriosis and uterine fibroids and risk of premature mortality: prospective cohort study Open
Objective To prospectively assess the effect of endometriosis and uterine fibroids on the long term risk of premature mortality (younger than 70 years). Design Prospective cohort study Setting The Nurses’ Health Study II, United States (19…
View article: Enhancing genetic association power in endometriosis through unsupervised clustering of clinical subtypes identified from electronic health records
Enhancing genetic association power in endometriosis through unsupervised clustering of clinical subtypes identified from electronic health records Open
Endometriosis is a complex and heterogeneous condition affecting 10% of reproductive-age women, and yet, it often goes undiagnosed for several years. Limited observed heritability (7%) of large genetic association studies may be attributab…
View article: Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice
Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice Open
View article: Symptom flares in women with chronic pelvic pain: Questionnaire study within a cohort study (translational research in pelvic pain ( <scp>TRiPP</scp> ))
Symptom flares in women with chronic pelvic pain: Questionnaire study within a cohort study (translational research in pelvic pain ( <span>TRiPP</span> )) Open
Objective To quantify the variation, triggers and impact on quality of life of symptom flares in women with chronic pelvic pain (CPP). Design Cross‐sectional questionnaire within the Translational Research in Pelvic Pain clinical cohort st…
View article: The Association between Endometriosis and Immunological diseases
The Association between Endometriosis and Immunological diseases Open
The evidence for a greater prevalence of immunological-diseases among endometriosis patients has varied in robustness and been subject to selection bias. We investigated the phenotypic and genetic association between endometriosis and 31 i…
View article: Association between COVID-19 vaccination and menstruation: a state of the science review
Association between COVID-19 vaccination and menstruation: a state of the science review Open
Introduction Menstrual health is a key patient-reported outcome beyond its importance as a general indicator of health and fertility. However, menstrual function was not measured in the clinical trials of COVID-19 vaccines. The purpose of …
View article: Plasma microRNA expression in adolescents and young adults with endometriosis: the importance of hormone use
Plasma microRNA expression in adolescents and young adults with endometriosis: the importance of hormone use Open
Introduction Prior studies have investigated the diagnostic potential of microRNA (miRNA) expression profiles for endometriosis. However, the vast majority of previous studies have only included adult women. Therefore, we sought to investi…
View article: World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: V. Physical examination standards in endometriosis research
World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: V. Physical examination standards in endometriosis research Open
The EPHect-PE standards will facilitate the standardized documentation of the physical examination, including the assessment and documentation of examination phenotyping of endometriosis-associated pelvic pain.
View article: Laparoscopically confirmed endometriosis and anti-Müllerian hormone levels: Findings from the Nurses' Health Study II
Laparoscopically confirmed endometriosis and anti-Müllerian hormone levels: Findings from the Nurses' Health Study II Open
View article: Pelvic pain symptoms and endometriosis characteristics in relation to oxidative stress among adolescents and adults with and without surgically-confirmed endometriosis
Pelvic pain symptoms and endometriosis characteristics in relation to oxidative stress among adolescents and adults with and without surgically-confirmed endometriosis Open
Background: While the majority of reproductive-aged females will experience pelvic pain during their lives, biological mechanisms underlying pelvic pain are not well understood. We investigated associations between pelvic pain symptoms and…
View article: Differences in characteristics and use of complementary and alternative methods for coping with endometriosis-associated acyclic pelvic pain across adolescence and adulthood
Differences in characteristics and use of complementary and alternative methods for coping with endometriosis-associated acyclic pelvic pain across adolescence and adulthood Open
Introduction Over four million women in the US alone have been diagnosed with endometriosis. For those living with this disease, surgery and hormonal treatment reduce associated pelvic pain in some, while others continue to experience life…
View article: Visualized peritoneal fluid variation in adolescents and young adults with endometriosis: is there more to it?
Visualized peritoneal fluid variation in adolescents and young adults with endometriosis: is there more to it? Open
Background Peritoneal fluid is a medium for endometriosis-associated biomarker discovery from which the local peritoneal environment and pathophysiologic pathways are often inferred. Therefore, we evaluated the associations between periton…
View article: Targeting NGF but not VEGF or BDNF signaling reduces endometriosis-associated pain in mice
Targeting NGF but not VEGF or BDNF signaling reduces endometriosis-associated pain in mice Open
Introduction Endometriosis is a chronic inflammatory disease that affects ∼10% of women. A significant fraction of patients experience limited or no efficacy with current therapies. Tissue adjacent to endometriosis lesions often exhibits i…
View article: Time for global health policy and research leaders to prioritize endometriosis
Time for global health policy and research leaders to prioritize endometriosis Open
View article: Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function
Global endometrial DNA methylation analysis reveals insights into mQTL regulation and associated endometriosis disease risk and endometrial function Open
Endometriosis is a leading cause of pain and infertility affecting millions of women globally. Herein, we characterize variation in DNA methylation (DNAm) and its association with menstrual cycle phase, endometriosis, and genetic variants …