Scott M. Bartell
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View article: Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype
Associations between per- and polyfluoroalkyl substances and metabolic dysfunction-associated steatotic liver disease in adolescents and young adults: modifying roles of age, lifestyle factors, and PNPLA3 genotype Open
Studies in youth on per- and polyfluoroalkyl substances (PFAS) exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) are limited. The study aimed to evaluate associations between PFAS and MASLD risk and the modifyin…
View article: Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents
Translational framework linking perfluoroheptanoic acid (PFHpA) exposure to metabolic dysfunction associated steatotic liver disease in adolescents Open
This study offers evidence implicating PFHpA, a short-chain unregulated PFAS congener, in MASLD development in adolescents, and highlights the critical role of protein dysregulation in disease pathogenesis. The molecular mechanisms identif…
View article: <scp>PFAS</scp> Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen‐<scp>LABS</scp> Study
<span>PFAS</span> Exposure and Postoperative Weight Regain in Adolescents After Bariatric Surgery: Findings From the Teen‐<span>LABS</span> Study Open
Objective Weight regain following bariatric surgery remains a clinical challenge, with limited understanding of contributing environmental factors. Per‐ and polyfluoroalkyl substances (PFAS), persistent chemicals linked to metabolic dysfun…
View article: Beyond the Surface: Mapping DDE’s Metabolic Footprint on Adolescent Obesity
Beyond the Surface: Mapping DDE’s Metabolic Footprint on Adolescent Obesity Open
These findings enhance our understanding of DDE's obesogenic effect. The involved metabolic changes could attenuate the efficacy of bariatric surgery in achieving sustained weight loss, underscoring the importance of integrating environmen…
View article: Metabolic Signatures in Adipose Tissue Linking Lipophilic Persistent Organic Pollutant Mixtures to Blood Pressure Five Years After Bariatric Surgery Among Adolescents
Metabolic Signatures in Adipose Tissue Linking Lipophilic Persistent Organic Pollutant Mixtures to Blood Pressure Five Years After Bariatric Surgery Among Adolescents Open
Persistent organic pollutants (POPs) are lipophilic environmental contaminants accumulated in the adipose tissue. Weight loss interventions, such as bariatric surgery, can mobilize POPs from adipose tissue into the bloodstream. We hypothes…
View article: Exposure to per‐ and polyfluoroalkyl substances in residential settled dust and risk of childhood acute lymphoblastic leukemia
Exposure to per‐ and polyfluoroalkyl substances in residential settled dust and risk of childhood acute lymphoblastic leukemia Open
Per‐ and polyfluoroalkyl substances (PFAS) are ubiquitous. Young children are commonly exposed to these chemicals via ingestion of settled dust. Several PFAS have been associated with cancers in adults, yet little is known about the risk i…
View article: Classroom air quality in a randomized crossover trial with portable HEPA air cleaners
Classroom air quality in a randomized crossover trial with portable HEPA air cleaners Open
Background Children living in communities with lower socioeconomic status and higher minority populations are often disproportionately exposed to particulate matter (PM) compared to children living in other communities. Objective We assess…
View article: Assessment of modeled serum per- and polyfluoroalkyl substances concentrations from exposure estimates for pregnant women in the general population in comparison to previously measured serum concentrations
Assessment of modeled serum per- and polyfluoroalkyl substances concentrations from exposure estimates for pregnant women in the general population in comparison to previously measured serum concentrations Open
When drinking water is uncontaminated, exposure to PFAS is thought to occur primarily via ingestion of food and indoor dust. To understand the background exposure during prenatal periods, this study examined whether published estimates of …
View article: How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population?
How well does a single blood sample represent long-term exposure for epidemiological studies of PFOA among men in the general population? Open
Many epidemiological studies use a single blood sample per participant to assess exposure, but it is unclear how well a single sample represents longer term exposure. We performed a simulation study using summary statistics for repeated se…
View article: PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth—a translational research framework
PFHpA alters lipid metabolism and increases the risk of metabolic dysfunction-associated steatotic liver disease in youth—a translational research framework Open
To address the growing epidemic of liver disease, particularly in pediatric populations, it is crucial to identify modifiable risk factors for the development and progression of metabolic dysfunction-associated steatotic liver disease (MAS…
View article: A Novel Approach to Integrate Human Biomonitoring Data with Model Predicted Dietary Exposures: A Crop Protection Chemical Case Study Using Lambda-Cyhalothrin
A Novel Approach to Integrate Human Biomonitoring Data with Model Predicted Dietary Exposures: A Crop Protection Chemical Case Study Using Lambda-Cyhalothrin Open
The appropriate use of human biomonitoring data to model population chemical exposures is challenging, especially for rapidly metabolized chemicals, such as agricultural chemicals. The objective of this study is to demonstrate a novel appr…
View article: Exposure to 4,4′‐<scp>DDE</scp> in visceral adipose tissue and weight loss in adolescents from the <scp>Teen‐LABS</scp> cohort
Exposure to 4,4′‐<span>DDE</span> in visceral adipose tissue and weight loss in adolescents from the <span>Teen‐LABS</span> cohort Open
Objective Dichlorodiphenyldichloroethylene (DDE), an obesogen accumulating in adipose tissue, is released into circulation with weight loss, although its impact is underexplored among adolescents. We tested the association using an integra…
View article: Potential Effects of Long-Term Exposure to Air Pollution on Dementia: A Longitudinal Analysis in American Indians Aged 55 Years and Older
Potential Effects of Long-Term Exposure to Air Pollution on Dementia: A Longitudinal Analysis in American Indians Aged 55 Years and Older Open
(1) Background: American Indians are disproportionately affected by air pollution, an important risk factor for dementia. However, few studies have investigated the effects of air pollution on the risk of dementia among American Indians. (…
View article: Paired Liver:Plasma PFAS Concentration Ratios from Adolescents in the Teen-LABS Study and Derivation of Empirical and Mass Balance Models to Predict and Explain Liver PFAS Accumulation
Paired Liver:Plasma PFAS Concentration Ratios from Adolescents in the Teen-LABS Study and Derivation of Empirical and Mass Balance Models to Predict and Explain Liver PFAS Accumulation Open
Animal studies have pointed at the liver as a hotspot for per- and polyfluoroalkyl substances (PFAS) accumulation and toxicity; however, these findings have not been replicated in human populations. We measured concentrations of seven PFAS…
View article: Exposure to DDE and BMI among adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study
Exposure to DDE and BMI among adolescents in the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) Study Open
BACKGROUND AND AIM: Dichlorodiphenyldichloroethylene (DDE) is considered an obesogen, as it can alter the individual's susceptibility to develop obesity. Bariatric surgery is effective in reducing weight among adolescents with obesity. How…
View article: PFAS exposure and changes in the extracellular microRNA profile in a cohort of adolescents undergoing bariatric surgery
PFAS exposure and changes in the extracellular microRNA profile in a cohort of adolescents undergoing bariatric surgery Open
BACKGROUND AND AIM: Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and accumulate in humans, leading to adverse health effects, such as hepatotoxicity. Little is known about the modes of …
View article: Unmatched spatially stratified controls: A simulation study examining efficiency and precision using spatially-diverse controls and generalized additive models
Unmatched spatially stratified controls: A simulation study examining efficiency and precision using spatially-diverse controls and generalized additive models Open
Unmatched spatially stratified random sampling (SSRS) of non-cases selects geographically balanced controls by dividing the study area into spatial strata and randomly selecting controls from all non-cases within each stratum. The performa…