Stan Gronthos
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View article: Overcoming challenges in cartilage regeneration: The role of chondrogenic inducers
Overcoming challenges in cartilage regeneration: The role of chondrogenic inducers Open
Cartilage regeneration presents unique challenges due to its avascular structure, sparse cell population, and limited regenerative capacity. Recent years have seen significant advancements in the field, which warrant an integrated review t…
View article: DNA hydroxy methylases Tet1 and Tet2 regulate bone aging and bone marrow stromal cell metabolism through the IGF-1/mTOR signaling axis
DNA hydroxy methylases Tet1 and Tet2 regulate bone aging and bone marrow stromal cell metabolism through the IGF-1/mTOR signaling axis Open
The Ten-Eleven Translocases (Tet) family of DNA hydroxymethylases have recently been implicated in bone development, with Tet1 and Tet2 mediating Bone Marrow Stromal Cell (BMSC) growth and osteogenic differentiation. The present study inve…
View article: Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma
Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma Open
The risk of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) increases with advancing age, suggesting that progression may be influenced by age-related changes within the bone marrow (BM) mi…
View article: Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation
Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation Open
Understanding the molecular mechanisms of differentiation is important for regenerative medicine and developmental biology. This study aims to characterise the role of the glycolysis/oxidative phosphorylation balance as a driver of mesench…
View article: Molars to Medicine: A Focused Review on the Pre-Clinical Investigation and Treatment of Secondary Degeneration following Spinal Cord Injury Using Dental Stem Cells
Molars to Medicine: A Focused Review on the Pre-Clinical Investigation and Treatment of Secondary Degeneration following Spinal Cord Injury Using Dental Stem Cells Open
Spinal cord injury (SCI) can result in the permanent loss of mobility, sensation, and autonomic function. Secondary degeneration after SCI both initiates and propagates a hostile microenvironment that is resistant to natural repair mechani…
View article: Targeting of C-ROS-1 Activity Using a Controlled Release Carrier to Treat Craniosynostosis in a Preclinical Model of Saethre-Chotzen Syndrome
Targeting of C-ROS-1 Activity Using a Controlled Release Carrier to Treat Craniosynostosis in a Preclinical Model of Saethre-Chotzen Syndrome Open
Saethre-Chotzen syndrome (SCS) is one of the most prevalent craniosynostosis, caused by a loss-of-function mutation in the TWIST-1 gene, with current treatment options relying on major invasive transcranial surgery. TWIST-1 haploinsufficie…
View article: Novel monocyte sub-populations revealed by detailed analysis of CD43 and CD11b expression in Sprague Dawley rats
Novel monocyte sub-populations revealed by detailed analysis of CD43 and CD11b expression in Sprague Dawley rats Open
Monocytes are a diverse population of white blood cells with critical roles in immunity and inflammation. The rat is commonly used for immunological investigations, but comprehensive characterization of rat monocytes/macrophages has been h…
View article: Novel monocyte sub-populations in Sprague Dawley rats revealed by detailed analysis of CD43 and CD11b expression using a single-stain 11-colour fluorescence activated cell sorting protocol
Novel monocyte sub-populations in Sprague Dawley rats revealed by detailed analysis of CD43 and CD11b expression using a single-stain 11-colour fluorescence activated cell sorting protocol Open
Monocytes are a diverse population of white blood cells with critical roles in immunity and inflammation. The rat is commonly used for immunological investigations, but comprehensive characterization of rat monocytes/macrophages has been h…
View article: Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis
Loss of Grem1-lineage chondrogenic progenitor cells causes osteoarthritis Open
Osteoarthritis (OA) is characterised by an irreversible degeneration of articular cartilage. Here we show that the BMP-antagonist Gremlin 1 ( Grem1 ) marks a bipotent chondrogenic and osteogenic progenitor cell population within the articu…
View article: Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
GSEA for genes upregulated by overexpression of HIF-2alpha in LP-1 cells
View article: Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
GSEA for genes upregulated by overexpression of HIF-2alpha in LP-1 cells
View article: Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 2. Migration towards CXCL12 and cell surface CXCR4 expression is downregulated by CXCL12 treatment
View article: Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 4. CXCL12 does not inhibit response to CCL3 in human MM cell lines
View article: Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Disease progression and relapse in multiple myeloma is dependent on the ability of the multiple myeloma plasma cells (PC) to reenter the circulation and disseminate throughout the bone marrow. Increased bone marrow hypoxia is associated wi…
View article: Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 3. CCR1 expression is upregulated by hypoxia in human MM cell lines
View article: Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 5. Cell surface expression of CXCR4 and CCR1 in newly diagnosed MM patients
View article: Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 3 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 3. CCR1 expression is upregulated by hypoxia in human MM cell lines
View article: Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Disease progression and relapse in multiple myeloma is dependent on the ability of the multiple myeloma plasma cells (PC) to reenter the circulation and disseminate throughout the bone marrow. Increased bone marrow hypoxia is associated wi…
View article: Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 5 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 5. Cell surface expression of CXCR4 and CCR1 in newly diagnosed MM patients
View article: Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 1. Overexpression of HIF-2α and CXCL12 in the HMCLs LP-1 and RPMI-8226
View article: Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Table of genes dysregulated with overexpression of HIF-2alpha in LP-1 cells
View article: Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supplementary Figure Legends and Methods
View article: Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 1. Overexpression of HIF-2α and CXCL12 in the HMCLs LP-1 and RPMI-8226
View article: Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 2 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 2. Migration towards CXCL12 and cell surface CXCR4 expression is downregulated by CXCL12 treatment
View article: Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Table 1 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Table of genes dysregulated with overexpression of HIF-2alpha in LP-1 cells
View article: Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supplementary Data from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supplementary Figure Legends and Methods
View article: Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1
Supp Figure 4 from HIF-2α Promotes Dissemination of Plasma Cells in Multiple Myeloma by Regulating CXCL12/CXCR4 and CCR1 Open
Supp. Figure 4. CXCL12 does not inhibit response to CCL3 in human MM cell lines
View article: Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging
Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging Open
Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as …