Stanley Chang
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View article: Does Obesity Predispose Patients to Superior Semicircular Canal Dehiscence?
Does Obesity Predispose Patients to Superior Semicircular Canal Dehiscence? Open
BMI = body mass index; CSFO = chronic spontaneous flow obstruction; IIH = idiopathic intracranial hypertension; OSA = obstructive sleep apnea; SD = standard deviation; SSCD = superior semicircular canal dehiscence.
View article: Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3
Ubiquitin-specific protease 13 promotes colorectal cancer progression by stabilizing mitogen-activated protein kinase kinase 3 Open
The deubiquitinase ubiquitin-specific protease 13 (USP13) has been implicated in various cancers, yet its precise molecular function and clinical significance in colorectal cancer (CRC) remain poorly defined. Here, we identify USP13 as a c…
View article: Ultrasound Assessment of Gaze-induced Posterior Eyewall Deformation in Highly Myopic Eyes
Ultrasound Assessment of Gaze-induced Posterior Eyewall Deformation in Highly Myopic Eyes Open
Downward gaze results in a significant increase in posterior eyewall concavity in highly myopic eyes after accounting for AL and staphyloma presence. In comparison with downward gaze, upgaze resulted in a lower magnitude, but significant c…
View article: Outcomes of four-point suture fixated and two-point sutureless posterior chamber IOLs combined with pars plana vitrectomy
Outcomes of four-point suture fixated and two-point sutureless posterior chamber IOLs combined with pars plana vitrectomy Open
Background While each scleral fixation method has its own advantages, there is a lack of strong evidence to suggest a superior technique. Advances in cataract surgery expand patient eligibility for successful cataract extraction, benefitti…
View article: Analysis of SARS-CoV-2 RNA on surfaces in New York City
Analysis of SARS-CoV-2 RNA on surfaces in New York City Open
Though COVID-19 is currently widespread in the United States, this study shows that health care personnel working in New York City at the Columbia University Irving Medical Center have a low chance of encountering viral RNA on surfaces the…
View article: Outcomes of Four-Point Suture Fixated And Two-Point Sutureless Posterior Chamber IOLs Combined With Pars Plana Vitrectomy
Outcomes of Four-Point Suture Fixated And Two-Point Sutureless Posterior Chamber IOLs Combined With Pars Plana Vitrectomy Open
Background: While each scleral fixation method has its own advantages, there is a lack of strong evidence to suggest a superior technique. Advances in cataract surgery expand patient eligibility for successful cataract extraction, benefitt…
View article: Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium
Shared Features in Retinal Disorders With Involvement of Retinal Pigment Epithelium Open
When using spectral domain optical coherence tomography (SD-OCT) to inform the status of outer retina, we have noted discrete hyperreflective lesions extending through photoreceptor-attributable bands that have a similar presentation in mu…
View article: Patient Concerns Regarding Suspended Ophthalmic Care Due to COVID-19
Patient Concerns Regarding Suspended Ophthalmic Care Due to COVID-19 Open
Purpose: The temporary cessation and profound changes in ophthalmic care delivery that occurred as a result of the coronavirus disease 2019 (COVID-19) pandemic have yet to be fully understood. Our objective is to assess patients’ self-repo…
View article: Frequency of Urgent or Emergent Vitreoretinal Surgical Procedures in the United States During the COVID-19 Pandemic
Frequency of Urgent or Emergent Vitreoretinal Surgical Procedures in the United States During the COVID-19 Pandemic Open
Although the AAO endorsed the continued performance of urgent or emergent vitreoretinal surgical procedures, the frequency of such procedures throughout the country experienced a substantial decrease that may persist after the COVID-19 pan…
View article: Central Serous Chorioretinopathy Analyzed by Multimodal Imaging
Central Serous Chorioretinopathy Analyzed by Multimodal Imaging Open
Foci of elevated qAF at some stages of CSC contribute to the natural history of the disease.
View article: Optic nerve tortuosity and displacements during horizontal eye movements in healthy and highly myopic subjects
Optic nerve tortuosity and displacements during horizontal eye movements in healthy and highly myopic subjects Open
Purpose (1) To assess the morphology and 3D displacements of the eye globe and optic nerve (ON) in adduction/abduction using magnetic resonance imaging (MRI). (2) To assess differences between healthy emmetropic and highly myopic (HM) subj…
View article: Optical coherence tomography-based consensus definition for lamellar macular hole
Optical coherence tomography-based consensus definition for lamellar macular hole Open
Background A consensus on an optical coherence tomography definition of lamellar macular hole (LMH) and similar conditions is needed. Methods The panel reviewed relevant peer-reviewed literature to reach an accord on LMH definition and to …
View article: A Preliminary Case Study of Promoting Teacher Professional Development via Post-Lesson Debriefing with the Support of Sokrates Cloud Services
A Preliminary Case Study of Promoting Teacher Professional Development via Post-Lesson Debriefing with the Support of Sokrates Cloud Services Open
During the process of teacher professional development, debriefing serves as a critical element, which not only helps teachers reflect on their own teaching practice but also helps all peer teachers promote their professional development. …
View article: Generation of two iPS cell lines (FRIMOi003-A and FRIMOi004-A) derived from Stargardt patients carrying ABCA4 compound heterozygous mutations
Generation of two iPS cell lines (FRIMOi003-A and FRIMOi004-A) derived from Stargardt patients carrying ABCA4 compound heterozygous mutations Open
Recessive Stargardt disease (STGD1) is an autosomal recessive retinal dystrophy, caused by mutations in the retina-specific ATP-binding cassette transporter (ABCA4) gene, which plays a role as a retinaldehyde flippase in the photoreceptor …
View article: Generation of an induced pluripotent stem cell line (FRIMOi002-A) from a retinitis pigmentosa patient carrying compound heterozygous mutations in USH2A gene
Generation of an induced pluripotent stem cell line (FRIMOi002-A) from a retinitis pigmentosa patient carrying compound heterozygous mutations in USH2A gene Open
A human induced pluripotent stem cell (iPSC) line was generated from a female patient affected by autosomal recessive retinitis pigmentosa with two mutations in the USH2A gene: c.2209C > T (p.Arg737Ter) and c.8693A > C (p.Tyr2898Ser). Skin…
View article: Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations
Establishment and characterization of an iPSC line (FRIMOi001-A) derived from a retinitis pigmentosa patient carrying PDE6A mutations Open
Retinitis pigmentosa (RP) refers to a clinical and genetic heterogeneous group of inherited retinal degenerations characterized by photoreceptor cell death. In this work, we have generated an induced pluripotent stem cell (iPSC) line deriv…
View article: Late-onset pattern macular dystrophy mimicking <i>ABCA4</i> and <i>PRPH2</i> disease is caused by a homozygous frameshift mutation in <i>ROM1</i>
Late-onset pattern macular dystrophy mimicking <i>ABCA4</i> and <i>PRPH2</i> disease is caused by a homozygous frameshift mutation in <i>ROM1</i> Open
ROM1 (retinal outer segment membrane protein 1) is a 351-amino acid integral membrane protein on Chromosome 11q, with high structural similarity to PRPH2/RDS. Localized at the rims of photoreceptor outer segments (OSs), it is required for …