Explanipedia

Balancing SHH and BMP/FGF10 to specify tuberal hypothalamic neurons and glia Open

Kavitha Chinnaiya, Ian Groves, Elizabeth Manning, Elsie Place, Caitlyn Furley , et al. · 2025

The tuberal hypothalamus harbours clinically important neuronal and glial populations with central roles in energy homeostasis. Previous work has revealed key roles for SHH and BMP signalling in tuberal progenitor specification, and sugges…

A new resource of clonal pluripotent human stem cell lines exhibiting inter- and intra-embryo consistency and variability Open

Stanley E. Strawbridge, Lawrence E. Bates, Connor Ross, Kenneth Jones, Takuya Azami , et al. · 2025

Human naive pluripotent stem cells can generate all somatic tissues and extra-embryonic components of the blastocyst. We derived multiple clonal naive pluripotent stem cell lines from individual embryos by physical separation of inner cell…

Donor embryonic stem cells displace host cells of 8-cell-stage chimeras to the extra-embryonic lineages by spatial crowding and FGF4 signalling Open

Stanley E. Strawbridge, Anna Katharina Schrattel, Peter Humphreys, Kenneth A. Jones, Jérôme Artus , et al. · 2025

Following mouse embryo compaction, outer cells become trophectoderm, while inner cells form the inner cell mass (ICM), later differentiating into primitive endoderm and epiblast during blastocyst formation. Trophectoderm specification is d…

A non-catalytic role for MLL2 in controlling chromatin organisation and mobility during the priming of pluripotent cells for differentiation Open

M. Steindel, Oliver Davis, Katrin Neumann, Liviu Pirvan, Gökçe Agsu , et al. · 2025

The chromatin regulator MLL2 (KMT2B) is the primary histone 3 lysine 4 (H3K4) trimethyltransferase acting at bivalent promoters in embryonic stem cells (ESCs) and is required for differentiation toward neuroectoderm. Here, we demonstrate t…

Donor embryonic stem cells impede host epiblast specification in 8-cell stage chimeras by crowding and FGF4 signalling Open

Stanley E. Strawbridge, Anna Katharina Schrattel, Peter Humphreys, Ken Jones, Jérôme Artus , et al. · 2024

During mouse embryo compaction, outer cells become trophectoderm, while inner cells form the inner cell mass (ICM), later differentiating into primitive endoderm and epiblast - source of embryonic stem cells (ESCs) - during blastocyst form…

Balancing Shh and Bmp/Fg10 Signals to Specify Hypothalamic Neurons and Glia Open

Marysia Placzek, Kavitha Chinnaiya, Ian Groves, Elizabeth Manning, Caitlyn Furley , et al. · 2024

insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology Open

Stanley E. Strawbridge, Agata Kurowski, Elena Corujo-Simón, Alastair Fletcher, Jennifer Nichols , et al. · 2023

A crucial aspect of embryology is relating the position of individual cells to the broader geometry of the embryo. A classic example of this is the first cell-fate decision of the mouse embryo, where interior cells become inner cell mass a…

Spatial profiling of early primate gastrulation in utero Open

Sophie Bergmann, Christopher A. Penfold, Erin Slatery, Dylan Siriwardena, Charis Drummer , et al. · 2022

insideOutside: an accessible algorithm for classifying interior and exterior points, with applications in embryology Open

Stanley E. Strawbridge, Agata Kurowski, Elena Corujo-Simón, Alastair Fletcher, Jennifer Nichols , et al. · 2021

A crucial aspect of embryology is relating the position of individual cells to the broader geometry of the embryo. A classic example of this is the first cell-fate decision of the mouse embryo, where interior cells become inner cell mass a…

Human naive epiblast cells possess unrestricted lineage potential Open

Ge Guo, Giuliano Giuseppe Stirparo, Stanley E. Strawbridge, Daniel Spindlow, Jian Yang , et al. · 2021

OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms Open

Giuliano Giuseppe Stirparo, Agata Kurowski, Ayaka Yanagida, Lawrence E. Bates, Stanley E. Strawbridge , et al. · 2021

Significance We used single-cell whole-genome transcriptional profiling and protein quantification to investigate the role of OCT4 in establishing pluripotency in the murine embryo. Surprisingly, most pluripotency-associated factors are in…

Embryonic stem cells commit to differentiation by symmetric divisions following a variable lag period Open

Stanley E. Strawbridge, Guy B. Blanchard, Austin Smith, Hillel Kugler, Graziano Martello · 2020

Mouse embryonic stem (ES) cells are derived from the epiblast of the preimplantation embryo and retain the capacity to give rise to all embryo lineages. ES cells can be released into differentiation from a near-homogeneous maintenance cond…

Human Naïve Epiblast Cells Possess Unrestricted Lineage Potential Open

Ge Guo, Giuliano Giuseppe Stirparo, Stanley E. Strawbridge, Daniel Spindlow, Jian Yang , et al. · 2020

SUMMARY Classical mouse embryology has established a paradigm of early development driven by sequential lineage bifurcations. Accordingly, mouse embryonic stem cells derived from early epiblast have lost the potency to produce extraembryon…

Oct4 regulates embryonic pluripotency via metabolic mechanisms and Stat3 signalling Open

Giuliano Giuseppe Stirparo, Agata Kurowski, Stanley E. Strawbridge, Hannah T. Stuart, Thorsten Boroviak , et al. · 2020

OCT4 is a fundamental component of the molecular circuitry governing pluripotency in vivo and in vitro . To determine how OCT4 protects the pluripotent lineage from differentiation into trophoblast, we used single cell transcriptomics and …

Understanding the Dynamics of Embryonic Stem Cell Differentiation Open

Stanley E. Strawbridge · 2017

The two defining features of mouse embryonic stem (ES) cells are self-renewal and naive pluripotency, the ability to give rise to all cell lineages in the adult body. In addition to being a unique and interesting cell type, pluripotent ES …

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