Stanley Hooker
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View article: <i>RASA3</i> is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension
<i>RASA3</i> is a candidate gene in sickle cell disease‐associated pulmonary hypertension and pulmonary arterial hypertension Open
Pulmonary hypertension (PH) is associated with significant morbidity and mortality. RASA3 is a GTPase activating protein integral to angiogenesis and endothelial barrier function. In this study, we explore the association of RASA3 genetic …
View article: Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent
Genetic Contributions to Prostate Cancer Disparities in Men of West African Descent Open
Prostate cancer (PCa) is the second most frequently diagnosed malignancy and the second leading cause of death in men worldwide, after adjusting for age. According to the International Agency for Research on Cancer, continents such as Nort…
View article: Genetic loci associated with skin pigmentation in African Americans and their effects on vitamin D deficiency
Genetic loci associated with skin pigmentation in African Americans and their effects on vitamin D deficiency Open
A recent genome-wide association study (GWAS) in African descent populations identified novel loci associated with skin pigmentation. However, how genomic variations affect skin pigmentation and how these skin pigmentation gene variants af…
View article: Genetic Associations in the Vitamin D Receptor and Colorectal Cancer in African Americans and Caucasians
Genetic Associations in the Vitamin D Receptor and Colorectal Cancer in African Americans and Caucasians Open
Low vitamin D levels are associated with an increased incidence of colorectal cancer (CRC) and higher mortality from the disease. In the US, African Americans (AAs) have the highest CRC incidence and mortality and the lowest levels of vita…
View article: Contribution of higher risk genes and European admixture to Crohnʼs disease in African Americans:
Contribution of higher risk genes and European admixture to Crohnʼs disease in African Americans: Open
African Americans (AA) are an admixed population of West African (WA) and European ancestry (EA). Crohn's disease (CD) susceptibility genes have not been established. We therefore evaluated the contribution of European admixture and major …
View article: Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent
Genetic Heterogeneity in Colorectal Cancer Associations in Americans of African vs. European Descent Open
Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genomic regions. None of these studies included African Americans, who have the highest incidence and mortality from CRC in the US. For the 10 g…
View article: Leveraging genetic ancestry to study health disparities
Leveraging genetic ancestry to study health disparities Open
Research to understand human genomic variation and its implications in health has great potential to contribute in the reduction of health disparities. Biological anthropology can play important roles in genomics and health disparities res…
View article: Genetic ancestry, skin color and social attainment: The four cities study
Genetic ancestry, skin color and social attainment: The four cities study Open
Our findings suggest differences in skin pigmentation by geography and support regional variations in ancestry of US Blacks. Biomedical research should consider genetic ancestry and local historical/social context rather than relying solel…
View article: Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project
Rare variant associations with waist-to-hip ratio in European-American and African-American women from the NHLBI-Exome Sequencing Project Open
Waist-to-hip ratio (WHR), a relative comparison of waist and hip circumferences, is an easily accessible measurement of body fat distribution, in particular central abdominal fat. A high WHR indicates more intra-abdominal fat deposition an…
View article: Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines
Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines Open
Background: Given the scarcity of cell lines from underrepresented populations, it is imperative that genetic ancestry for these cell lines is characterized. Consequences of cell line mischaracterization include squandered resources and pu…
View article: A locus on chromosome 5 shows African ancestry–limited association with alloimmunization in sickle cell disease
A locus on chromosome 5 shows African ancestry–limited association with alloimmunization in sickle cell disease Open
Red blood cell (RBC) transfusion remains a critical therapeutic intervention in sickle cell disease (SCD); however, the apparent propensity of some patients to regularly develop RBC alloantibodies after transfusion presents a significant c…
View article: Breast cancer risk and genetic ancestry: a case–control study in Uruguay
Breast cancer risk and genetic ancestry: a case–control study in Uruguay Open
We have not found evidence that overall genetic ancestry differs between breast cancer patients and controls in Uruguay but we detected an association of the disease with a European mitochondrial lineage, which warrants further investigati…