Stanley J. Naides
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View article: B-121 Evaluation of anti-nuclear antibody (ANA) patterns and its associations with autoimmune disease biomarkers
B-121 Evaluation of anti-nuclear antibody (ANA) patterns and its associations with autoimmune disease biomarkers Open
Background The presence of anti-nuclear antibodies (ANA) is a hallmark for many systemic autoimmune rheumatic diseases (SARD). In this study, we evaluated ANA testing performed at Labcorp from 2015 to 2023. We investigated the associations…
View article: Calculated Globulin: Early Detection of Immunodeficiency
Calculated Globulin: Early Detection of Immunodeficiency Open
Serum calculated globulin (cGlob) (total protein – albumin) reflects immunoglobulins. We sought to validate cGlob as an aid to diagnosis of CVID using a large sample of patients with connected diagnostic testing from a national reference l…
View article: Dr. Naides replies
Dr. Naides replies Open
To the Editor: We thank Dr. Russell for raising the issue of reporting the false positivity rate of antinuclear antibody (ANA) indirect immunofluorescent assay (IFA) testing.1 It is difficult, however, for a laboratory to state a false pos…
View article: Highlights of the 33rd annual scientific meeting of the Association of Medical Laboratory Immunologists (AMLI)
Highlights of the 33rd annual scientific meeting of the Association of Medical Laboratory Immunologists (AMLI) Open
View article: Prevalence and significance of serum 14–3-3η in juvenile idiopathic arthritis
Prevalence and significance of serum 14–3-3η in juvenile idiopathic arthritis Open
Background Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14–3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (…
View article: 14-3-3η Protein as a Potential Biomarker in Juvenile Idiopathic Arthritis
14-3-3η Protein as a Potential Biomarker in Juvenile Idiopathic Arthritis Open
The 14-3-3η (eta) protein was evaluated as a biomarker in a cohort of patients with juvenile idiopathic arthritis (JIA), as well as disease- and healthy-controls, to determine its potential clinical utility. In this case-control study, lev…
View article: Prevalence and Significance of Serum 14-3-3η in Juvenile Idiopathic Arthritis
Prevalence and Significance of Serum 14-3-3η in Juvenile Idiopathic Arthritis Open
Background: Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14-3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide …
View article: Correctly Interpreting SARS-CoV-2 Serologic Assays
Correctly Interpreting SARS-CoV-2 Serologic Assays Open
The authors of Tang et al. (1) have incorrectly concluded that the Abbott SARS-CoV-2 assay demonstrated higher sensitivity and specificity than the EUROIMMUN Anti-SARS-CoV-2 IgG assay, despite also stating that overlapping of confidence in…
View article: Prevalence and Significance of Serum 14-3-3η(eta) in Juvenile Idiopathic Arthritis
Prevalence and Significance of Serum 14-3-3η(eta) in Juvenile Idiopathic Arthritis Open
Background Prompt diagnosis of juvenile idiopathic arthritis (JIA) is important to avoid long term complications. Elevated serum 14-3-3η levels improve the diagnostic sensitivity of rheumatoid factor (RF) and cyclic citrullinated peptide (…
View article: Reference intervals for lymphocyte subsets in preterm and term neonates without immune defects
Reference intervals for lymphocyte subsets in preterm and term neonates without immune defects Open
View article: Newborn Screening for Severe Combined Immunodeficiency and T-cell Lymphopenia in California, 2010–2017
Newborn Screening for Severe Combined Immunodeficiency and T-cell Lymphopenia in California, 2010–2017 Open
OBJECTIVES: Newborn screening for severe combined immunodeficiency (SCID) was instituted in California in 2010. In the ensuing 6.5 years, 3 252 156 infants in the state had DNA from dried blood spots assayed for T-cell receptor excision ci…
View article: Parvovirus B19V Nonstructural Protein NS1 Induces Double-Stranded Deoxyribonucleic Acid Autoantibodies and End-Organ Damage in Nonautoimmune Mice
Parvovirus B19V Nonstructural Protein NS1 Induces Double-Stranded Deoxyribonucleic Acid Autoantibodies and End-Organ Damage in Nonautoimmune Mice Open
This study demonstrated proof of principle in an animal model that virally modified dsDNA in apoptotic bodies could break tolerance to self dsDNA and induce dsDNA autoantibodies and end-organ damage.
View article: Variability in Testing for Antineutrophil Cytoplasmic Antibodies: A Survey of Participants in the College of American Pathologists Proficiency Testing Program
Variability in Testing for Antineutrophil Cytoplasmic Antibodies: A Survey of Participants in the College of American Pathologists Proficiency Testing Program Open
Context.—Variability in testing for antineutrophil cytoplasmic antibodies (ANCAs) contributes to confusion and controversy related to testing for vasculitis and other ANCA-associated diseases. Objectives.—To survey laboratory testing pract…
View article: 14-3-3η in “Seronegative” Rheumatoid Arthritis
14-3-3η in “Seronegative” Rheumatoid Arthritis Open
To the Editor: Serum 14-3-3η is a novel joint-derived proinflammatory mediator implicated in the pathogenesis of rheumatoid arthritis (RA)1. Unlike rheumatoid factor (RF) or anticitrullinated protein antibody (ACPA), which can arise as a c…