Stavros Stivaros
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View article: Radiological Predictors of Cognitive Impairment in Paediatric Brain Tumours Using Multiparametric Magnetic Resonance Imaging: A Review of Current Practice, Challenges and Future Directions
Radiological Predictors of Cognitive Impairment in Paediatric Brain Tumours Using Multiparametric Magnetic Resonance Imaging: A Review of Current Practice, Challenges and Future Directions Open
Paediatric brain tumours and their treatments are associated with long-term cognitive impairment. While the aetiology of cognitive impairment is complex and multifactorial, multiparametric Magnetic Resonance Imaging (MRI) can identify many…
View article: Primary diffuse leptomeningeal atypical teratoid/rhabdoid tumours (ATRT) of childhood: a molecularly characterised case report and literature review
Primary diffuse leptomeningeal atypical teratoid/rhabdoid tumours (ATRT) of childhood: a molecularly characterised case report and literature review Open
View article: IMG-21. HOW CAN WE BEST UTILISE HISTORICAL IMAGING DATASETS FOR RESEARCH IN PAEDIATRIC NEURO-ONCOLOGY? A REVIEW OF HISTORICAL PRE-OPERATIVE IMAGING PERFORMED FOR 92 PAEDIATRIC BRAIN TUMOUR PATIENTS WITH COMPARISON TO 2021 SIOPE GUIDELINES
IMG-21. HOW CAN WE BEST UTILISE HISTORICAL IMAGING DATASETS FOR RESEARCH IN PAEDIATRIC NEURO-ONCOLOGY? A REVIEW OF HISTORICAL PRE-OPERATIVE IMAGING PERFORMED FOR 92 PAEDIATRIC BRAIN TUMOUR PATIENTS WITH COMPARISON TO 2021 SIOPE GUIDELINES Open
BACKGROUND Utilisation of historical imaging is important for studying long-term outcomes in paediatric brain tumours often pooling data across multiple centres retrospectively over many years. Disparities in MRI sequence parameters, imagi…
View article: IMG-20. IDENTIFICATION OF PRE-OPERATIVE IMAGING FEATURES ASSOCIATED WITH COGNITIVE IMPAIRMENT IN CHILDREN WITH BRAIN TUMOURS USING A LANGUAGE MODELLING SYSTEM COMBINED WITH MACHINE LEARNING ANALYSIS
IMG-20. IDENTIFICATION OF PRE-OPERATIVE IMAGING FEATURES ASSOCIATED WITH COGNITIVE IMPAIRMENT IN CHILDREN WITH BRAIN TUMOURS USING A LANGUAGE MODELLING SYSTEM COMBINED WITH MACHINE LEARNING ANALYSIS Open
BACKGROUND Cognitive impairments caused by paediatric brain tumours negatively impact future quality-of-life. Impairments of processing speed and working memory are important contributors to challenges these children encounter in education…
View article: ATRT-03. PRIMARY DIFFUSE LEPTOMENINGEAL ATYPICAL TERATOID/RHABDOID TUMOR (ATRT) OF CHILDHOOD DEMONSTRATING UNEXPECTED IMPROVEMENT UPON CESSATION OF CONVENTIONAL THERAPY FOR PRESUMED PROGRESSION; A MOLECULARLY CHARACTERIZED CASE REPORT
ATRT-03. PRIMARY DIFFUSE LEPTOMENINGEAL ATYPICAL TERATOID/RHABDOID TUMOR (ATRT) OF CHILDHOOD DEMONSTRATING UNEXPECTED IMPROVEMENT UPON CESSATION OF CONVENTIONAL THERAPY FOR PRESUMED PROGRESSION; A MOLECULARLY CHARACTERIZED CASE REPORT Open
BACKGROUND Atypical teratoid/rhabdoid tumors (ATRTs) are malignant tumors of the central nervous system, typically presenting in the posterior fossa of very young children. Prognosis remains poor despite current therapy, while tumorigenesi…
View article: Can MRI biomarkers for hearing loss in enlarged vestibular aqueduct be measured reproducibly?
Can MRI biomarkers for hearing loss in enlarged vestibular aqueduct be measured reproducibly? Open
Objective: Morphological features of an enlarged endolymphatic duct (ED) and sac (ES) are imaging biomarkers for genotype and hearing loss phenotype. We determine which biomarkers can be measured in a reproducible manner, facilitating furt…
View article: ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1
ERN GENTURIS tumour surveillance guidelines for individuals with neurofibromatosis type 1 Open
View article: Radiation treatment of benign tumors in NF2-related-schwannomatosis: A national study of 266 irradiated patients showing a significant increase in malignancy/malignant progression
Radiation treatment of benign tumors in NF2-related-schwannomatosis: A national study of 266 irradiated patients showing a significant increase in malignancy/malignant progression Open
Background Radiation treatment of benign tumors in tumor predisposition syndromes is controversial, but short-term studies from treatment centers suggest safety despite apparent radiation-associated malignancy being reported. We determined…
View article: Non-invasive brain stimulation modulates GABAergic activity in neurofibromatosis 1
Non-invasive brain stimulation modulates GABAergic activity in neurofibromatosis 1 Open
View article: Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation
Updated diagnostic criteria and nomenclature for neurofibromatosis type 2 and schwannomatosis: An international consensus recommendation Open
View article: EPEN-01. Response assessment in pediatric intracranial ependymoma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group
EPEN-01. Response assessment in pediatric intracranial ependymoma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group Open
INTRODUCTION: Ependymomas remain a major cause of cancer-related death in childhood and adolescence, with recurrence occurring in up to 50% of patients. Despite exciting molecular advances in understanding ependymoma tumorigenesis and recu…
View article: Appendiceal involvement in pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a diagnostic challenge in the coronavirus disease (COVID) era
Appendiceal involvement in pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): a diagnostic challenge in the coronavirus disease (COVID) era Open
View article: ERN GENTURIS clinical practice guidelines for the diagnosis, treatment, management and surveillance of people with schwannomatosis
ERN GENTURIS clinical practice guidelines for the diagnosis, treatment, management and surveillance of people with schwannomatosis Open
View article: Neuroanatomical correlates of working memory performance in Neurofibromatosis 1
Neuroanatomical correlates of working memory performance in Neurofibromatosis 1 Open
Introduction Neurofibromatosis 1 (NF1) is a single-gene disorder associated with cognitive impairments, particularly with deficits in working memory. Prior research indicates that brain structure is affected in NF1, but it is unclear how t…
View article: The role of artificial intelligence in paediatric neuroradiology
The role of artificial intelligence in paediatric neuroradiology Open
View article: Rate and severity of radiological features of physical abuse in children during the first UK-wide COVID-19 enforced national lockdown
Rate and severity of radiological features of physical abuse in children during the first UK-wide COVID-19 enforced national lockdown Open
Rate and severity of radiological features of physical abuse in children during the first UK-wide COVID-19 enforced national lockdown. Objective To assess the number, type and outcome of radiological investigations for children presenting …
View article: Non-invasive Brain Stimulation Modulates GABAergic Activity in Neurofibromatosis 1
Non-invasive Brain Stimulation Modulates GABAergic Activity in Neurofibromatosis 1 Open
Neurofibromatosis 1 (NF1) is a single-gene disorder associated with cognitive phenotypes common to neurodevelopmental conditions such as Autism Spectrum Disorder (ASD) & Attention Deficit Hyperactivity Disorder (ADHD). GABAergic dysregulat…
View article: Neuroanatomical correlates of working memory performance in Neurofibromatosis 1
Neuroanatomical correlates of working memory performance in Neurofibromatosis 1 Open
Background Neurofibromatosis 1 (NF1) is a single-gene neurodevelopmental disorder associated with cognitive and behavioural impairments, particularly with deficits in working memory. This study investigates the cerebral volumetric differen…
View article: Non-Invasive Brain Stimulation Modulates GABAergic Activity In Neurofibromatosis 1
Non-Invasive Brain Stimulation Modulates GABAergic Activity In Neurofibromatosis 1 Open
BackgroundNeurofibromatosis 1 (NF1) is a single-gene disorder associated with cognitive phenotypes common to neurodevelopmental conditions such as Autism Spectrum Disorder (ASD) & Attention Deficit Hyperactivity Disorder (ADHD). GABAergic …
View article: Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation
Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation Open
View article: Assessment of 5-aminolevulinic acid induced fluorescence during re-do surgery for paediatric CNS tumours and correlation with pre-operative MRI contrast enhancement with review of 11 cases
Assessment of 5-aminolevulinic acid induced fluorescence during re-do surgery for paediatric CNS tumours and correlation with pre-operative MRI contrast enhancement with review of 11 cases Open
View article: Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study
Neuroimaging manifestations in children with SARS-CoV-2 infection: a multinational, multicentre collaborative study Open
View article: Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution
Disease course of neurofibromatosis type 2: a 30-year follow-up study of 353 patients seen at a single institution Open
Background Limited data exist on the disease course of neurofibromatosis type 2 (NF2) to guide clinical trial design. Methods A prospective database of patients meeting NF2 diagnostic criteria, reviewed between 1990 and 2020, was evaluated…
View article: EPEN-24. SIOP EPENDYMOMA II: CENTRAL EPENDYMOMA MANAGEMENT ADVISORY GROUP – THE UK EXPERIENCE
EPEN-24. SIOP EPENDYMOMA II: CENTRAL EPENDYMOMA MANAGEMENT ADVISORY GROUP – THE UK EXPERIENCE Open
Paediatric Ependymoma is the second most common malignant brain tumour of childhood with approximately 50% of cases recurring. It has been described as a “surgical” disease since patients who have undergone a gross total surgical resection…
View article: The importance of genetic counseling and screening for people with pathogenic <scp><i>SMARCE1</i></scp> variants: A family study
The importance of genetic counseling and screening for people with pathogenic <span><i>SMARCE1</i></span> variants: A family study Open
Clear cell meningioma (CCM) is a rare variant of meningioma. In recent years, an association between cranial and spinal CCMs and germline loss of function mutations in the SMARCE1 gene ( SWI/SNF chromatin remodeling complex subunit gene) h…
View article: An Unusual Case of Cerebellar Langerhans Cell Histiocytosis Relapse Post Bone Marrow Transplant for Systemic Disease
An Unusual Case of Cerebellar Langerhans Cell Histiocytosis Relapse Post Bone Marrow Transplant for Systemic Disease Open
Our patient was diagnosed with multisystemic Langerhans Cell Histiocytosis (LCH) at 5 months of age. She received an allogeneic matched unrelated transplant for refractory haematopoietic disease. 2 years later she represented with raised i…
View article: Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing
Incidence of mosaicism in 1055 de novo NF2 cases: much higher than previous estimates with high utility of next-generation sequencing Open
View article: Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature
Papillary craniopharyngioma in a 4-year-old girl with BRAF V600E mutation: a case report and review of the literature Open
View article: CRAN-31. PAPILLARY CRANIOPHARYNGIOMA WITH BRAF V600E MUTATION IN A FOUR YEAR OLD CHILD: A CASE REPORT AND REVIEW OF CLINICAL CASES FROM LITERATURE
CRAN-31. PAPILLARY CRANIOPHARYNGIOMA WITH BRAF V600E MUTATION IN A FOUR YEAR OLD CHILD: A CASE REPORT AND REVIEW OF CLINICAL CASES FROM LITERATURE Open
INTRODUCTION: We report a four year old girl with autistic spectrum disorder who was being investigated for symptomatic central hypothyroidism and potential growth hormone deficiency. Brain MR imaging revealed a large solid / cystic supras…
View article: RADI-15. PERFUSION IMAGING IN PRESUMED PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA: A UK REGIONAL ANALYSIS
RADI-15. PERFUSION IMAGING IN PRESUMED PEDIATRIC DIFFUSE INTRINSIC PONTINE GLIOMA: A UK REGIONAL ANALYSIS Open
INTRODUCTION: The radiological diagnosis of childhood diffuse intrinsic pontine glioma (DIPG) has historically been founded upon characteristic magnetic resonance imaging metrics. Modern neuro-imaging now incorporates multi-parametric phys…