Stavros Taraviras
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View article: Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids
Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids Open
The V-SVZ niche is vital for adult neurogenesis in mammals, yet its regulation in humans remains poorly understood. Current models, including brain organoids, fail to replicate the unique cytoarchitecture of this niche, particularly the mu…
View article: Ependymal and neural stem cells are close relatives
Ependymal and neural stem cells are close relatives Open
View article: Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering
Integrating Modern Technologies into Traditional Anterior Cruciate Ligament Tissue Engineering Open
The anterior cruciate ligament (ACL) is one of the most injured ligaments, with approximately 100,000 ACL reconstructions taking place annually in the United States. In order to successfully manage ACL rupture, it is of the utmost importan…
View article: Injectable and 3D-Printable Semi-Interpenetrating Polymer Networks Based on Modified Sodium Alginate for Cell Spheroid Formation
Injectable and 3D-Printable Semi-Interpenetrating Polymer Networks Based on Modified Sodium Alginate for Cell Spheroid Formation Open
We report on 3D-printable polymer networks based on the combination of modified alginate-based polymer blends; two alginate polymers were prepared, namely, a thermoresponsive polymer grafted with P(NIPAM86-co-NtBAM14…
View article: Ependymal cell lineage reprogramming as a potential therapeutic intervention for hydrocephalus
Ependymal cell lineage reprogramming as a potential therapeutic intervention for hydrocephalus Open
View article: SAT046 Canagliflozin Leads To Less Weight Gain, Confers Changes In The Gut Microbiota And Extends Life Span In Male C57BL6 Mice
SAT046 Canagliflozin Leads To Less Weight Gain, Confers Changes In The Gut Microbiota And Extends Life Span In Male C57BL6 Mice Open
Disclosure: E.E. Habeos: None. F. Filippopoulou: None. M. Kanakis: None. G.I. Habeos: None. N. Belmokhtar: None. P. Stathopoulou: None. G. Tsiamis: None. S. Taraviras: None. G. Lagoumintzis: None. D.V. Chartoumpekis: None. Introduction: SG…
View article: Data from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
Data from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior Open
The accurate execution of DNA replication requires a strict control of the replication licensing factors hCdt1 and hCdc6. The role of these key replication molecules in carcinogenesis has not been clarified. To examine how early during can…
View article: Data from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
Data from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior Open
The accurate execution of DNA replication requires a strict control of the replication licensing factors hCdt1 and hCdc6. The role of these key replication molecules in carcinogenesis has not been clarified. To examine how early during can…
View article: Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior Open
Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
View article: Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior Open
Supplementary Figures 1-7, Tables 1-2 from Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior
View article: Canagliflozin extends life span and leads to less weight gain in C57BL6 male mice
Canagliflozin extends life span and leads to less weight gain in C57BL6 male mice Open
SGLT2 inhibitors are widely prescribed drugs for type 2 diabetes and heart failure. It seems that their beneficial health effects are multifaceted and not only limited to the amelioration of glycemic profile. It is suggested that SGLT2 inh…
View article: Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts
Metabolic regulation of the neural stem cell fate: Unraveling new connections, establishing new concepts Open
The neural stem cell niche is a key regulator participating in the maintenance, regeneration, and repair of the brain. Within the niche neural stem cells (NSC) generate new neurons throughout life, which is important for tissue homeostasis…
View article: McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation
McIdas localizes at centrioles and controls centriole numbers through PLK4-dependent phosphorylation Open
SUMMARY The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can lead to cancer, developmental disorders and ciliopathies. Here, we show that McIdas -prev…
View article: Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress
Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress Open
View article: Posttranslational modification of microtubules by the MATCAP detyrosinase
Posttranslational modification of microtubules by the MATCAP detyrosinase Open
The detyrosination-tyrosination cycle involves the removal and religation of the C-terminal tyrosine of α-tubulin and is implicated in cognitive, cardiac, and mitotic defects. The vasohibin–small vasohibin-binding protein (SVBP) complex un…
View article: Advanced Gene-Targeting Therapies for Motor Neuron Diseases and Muscular Dystrophies
Advanced Gene-Targeting Therapies for Motor Neuron Diseases and Muscular Dystrophies Open
Gene therapy is a revolutionary, cutting-edge approach to permanently ameliorate or amend many neuromuscular diseases by targeting their genetic origins. Motor neuron diseases and muscular dystrophies, whose genetic causes are well known, …
View article: Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells
Small Molecule Inhibitor Targeting CDT1/Geminin Protein Complex Promotes DNA Damage and Cell Death in Cancer Cells Open
DNA replication initiation requires the loading of MCM2-7 complexes at the origins of replication during G1. Replication licensing renders chromatin competent for DNA replication and its tight regulation is essential to prevent aberrant DN…
View article: 3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots
3D Reconstitution of the Neural Stem Cell Niche: Connecting the Dots Open
Neural stem cells (NSCs) are important constituents of the nervous system, and they become constrained in two specific regions during adulthood: the subventricular zone (SVZ) and the subgranular zone (SGZ) of the dentate gyrus in the hippo…
View article: <i>In silico</i> analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity
<i>In silico</i> analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity Open
DNA replication is a complex and remarkably robust process: despite its inherent uncertainty, manifested through stochastic replication timing at a single-cell level, multiple control mechanisms ensure its accurate and timely completion ac…
View article: DNA Replication Control: Liquid-liquid Phase Separation Comes Into Play.
DNA Replication Control: Liquid-liquid Phase Separation Comes Into Play. Open
Liquid-liquid phase separation (LLPS) has been recently suggested as a new potential mechanism underpinning various organizational aspects of the cell, from the formation of sub-cellular, biomolecule enrichments to the assembly of organell…
View article: Ιn vivo imaging of DNA-bound minichromosome maintenance complex in embryonic mouse cortex
Ιn vivo imaging of DNA-bound minichromosome maintenance complex in embryonic mouse cortex Open
The recruitment of the minichromosome maintenance complex (MCM) on DNA replication origins is a critical process for faithful genome duplication termed licensing. Aberrant licensing has been associated with cancer and, recently, with neuro…
View article: A Custom Ultra-Low-Cost 3D Bioprinter Supports Cell Growth and Differentiation
A Custom Ultra-Low-Cost 3D Bioprinter Supports Cell Growth and Differentiation Open
Advances in 3D bioprinting have allowed the use of stem cells along with biomaterials and growth factors toward novel tissue engineering approaches. However, the cost of these systems along with their consumables is currently extremely hig…
View article: Aberrant replication licensing drives Copy Number Gains across species
Aberrant replication licensing drives Copy Number Gains across species Open
Copy Number Gains (CNGs) lead to genetic heterogeneity, driving evolution and carcinogenesis. The mechanisms promoting CNG formation however remain poorly characterized. We show that abnormal expression of the replication licensing factor …
View article: <i>In silico</i>analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity
<i>In silico</i>analysis of DNA re-replication across a complete genome reveals cell-to-cell heterogeneity and genome plasticity Open
DNA replication is a complex and remarkably robust process: despite its inherent uncertainty, manifested through stochastic replication timing at a single-cell level, multiple control mechanisms ensure its accurate and timely completion ac…
View article: Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication
Cortical Development and Brain Malformations: Insights From the Differential Regulation of Early Events of DNA Replication Open
During the development of the cortex distinct populations of Neural Stem Cells (NSCs) are defined by differences in their cell cycle duration, self-renewal capacity and transcriptional profile. A key difference across the distinct populati…
View article: Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members Open
View article: DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency
DNA Replication Inhibitor Geminin and Retinoic Acid Signaling Participate in Complex Interactions Associated With Pluripotency Open
A complex circuitry between retinoic acid signaling, SWI/SNF components, pluripotency factors including Oct4, Sox2 and Nanog and cell cycle regulators was identified. It is suggested that the DNA replication inhibitor geminin plays a centr…
View article: Direct binding of Cdt2 to PCNA is important for targeting the CRL4 <sup>Cdt2</sup> E3 ligase activity to Cdt1
Direct binding of Cdt2 to PCNA is important for targeting the CRL4 <sup>Cdt2</sup> E3 ligase activity to Cdt1 Open
The CRL4 Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of substrate degrons on proliferating cell nuclear antige…
View article: Direct binding of Cdt2 to PCNA is important for targeting the CRL4<sup>Cdt2</sup> E3 ligase activity to Cdt1
Direct binding of Cdt2 to PCNA is important for targeting the CRL4<sup>Cdt2</sup> E3 ligase activity to Cdt1 Open
The CRL4 Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression and genome stability, ubiquitinating substrates such as p21, Set8 and Cdt1, via a display of substrate degrons on PCNA. Here, we examine the hierarc…
View article: Visualizing the dynamics of histone variants in the S-phase nucleus
Visualizing the dynamics of histone variants in the S-phase nucleus Open