Stef Deyaert
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View article: The Effect of Sodium Benzoate on the Gut Microbiome Across Age Groups
The Effect of Sodium Benzoate on the Gut Microbiome Across Age Groups Open
The food additive sodium benzoate (SB) has been used for decades as an antimicrobial to prevent food spoilage. SB has been deemed to pose no risk to human health when consumed at levels under 5 mg/kg body weight per day; however, when many…
View article: Hydrogen Sulfide Has a Minor Impact on Human Gut Microbiota Across Age Groups
Hydrogen Sulfide Has a Minor Impact on Human Gut Microbiota Across Age Groups Open
Hydrogen sulfide (H2S) can be produced from the metabolism of foods containing sulfur in the gastrointestinal tract (GIT). At low doses, H2S regulates the gut microbial community and supports GIT health, but depending on dose, age, and ind…
View article: d-Allulose and erythritol increase butyrate production and impact the gut microbiota in healthy adults and adults with type-2 diabetes ex vivo
d-Allulose and erythritol increase butyrate production and impact the gut microbiota in healthy adults and adults with type-2 diabetes ex vivo Open
Type-2 diabetes mellitus (T2DM) is associated with a reduction of butyrate-producing gut bacteria. d -allulose and erythritol are low-no-calorie sweeteners (LNCS) used as sugar substitutes to reduce high free sugar intakes associated with …
View article: The Bifidogenic Effect of 2’Fucosyllactose Is Driven by Age-Specific Bifidobacterium Species, Demonstrating Age as an Important Factor for Gut Microbiome Targeted Precision Medicine
The Bifidogenic Effect of 2’Fucosyllactose Is Driven by Age-Specific Bifidobacterium Species, Demonstrating Age as an Important Factor for Gut Microbiome Targeted Precision Medicine Open
Background: The human gut microbiota develops in concordance with its host over a lifetime, resulting in age-related shifts in community structure and metabolic function. Little is known about whether these changes impact the community’s r…
View article: Impact of two human milk oligosaccharides and lactose on the faecal microbiome of infants with probable cow’s milk allergy
Impact of two human milk oligosaccharides and lactose on the faecal microbiome of infants with probable cow’s milk allergy Open
Cow’s milk protein allergy (CMPA) in infancy is associated with intestinal microbial dysbiosis, characterised by low Bifidobacteriaceae levels. The present study aimed to investigate the impact of two human milk oligosaccharides (HMO), lac…
View article: Functional Muffins Exert Bifidogenic Effects along with Highly Product-Specific Effects on the Human Gut Microbiota Ex Vivo
Functional Muffins Exert Bifidogenic Effects along with Highly Product-Specific Effects on the Human Gut Microbiota Ex Vivo Open
GoodBiome™ Foods are functional foods containing a probiotic (Bacillus subtilis HU58™) and prebiotics (mainly inulin). Their effects on the human gut microbiota were assessed using ex vivo SIFR® technology, which has been validated to prov…
View article: HMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses
HMOs Impact the Gut Microbiome of Children and Adults Starting from Low Predicted Daily Doses Open
Recent studies suggest that the dietary intake of human milk oligosaccharides (HMOs) provides health benefits from infancy up to adulthood. Thus far, beneficial changes in the adult gut microbiome have been observed at oral doses of 5–20 g…
View article: Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste
Tomato seed extract promotes health of the gut microbiota and demonstrates a potential new way to valorize tomato waste Open
The current effort to valorize waste byproducts to increase sustainability and reduce agricultural loss has stimulated interest in potential utilization of waste components as health-promoting supplements. Tomato seeds are often discarded …
View article: Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts)
Targeted remodeling of the human gut microbiome using Juemingzi (Senna seed extracts) Open
The genus Senna contains globally distributed plant species of which the leaves, roots, and seeds have multiple traditional medicinal and nutritional uses. Notable chemical compounds derived from Senna spp. include sennosides and emodin wh…
View article: Metagenomes and metagenome-assembled genomes from <i>ex vivo</i> fecal incubations of six unique donors
Metagenomes and metagenome-assembled genomes from <i>ex vivo</i> fecal incubations of six unique donors Open
We present a donor-specific collection of 78 metagenomes (13/donor) and 143 metagenome-assembled genomes (MAGs), representing the gut microbiomes of six healthy adult human donors. In addition to adding to the catalog of publicly available…
View article: Impact of Baizhu, Daqingye, and Hehuanhua extracts on the human gut microbiome
Impact of Baizhu, Daqingye, and Hehuanhua extracts on the human gut microbiome Open
Introduction In traditional Chinese medicine, the rhizome of Atractylodes macrocephala (Baizhu), the leaves of Isatis indigotica (Daqingye), and the flowers of Albizia julibrissin (Hehuanhua) have been used to treat gastrointestinal illnes…
View article: Ex vivo impact of human milk oligosaccharides and lactose on microbiome in infants with cow's milk protein allergy
Ex vivo impact of human milk oligosaccharides and lactose on microbiome in infants with cow's milk protein allergy Open
Cow’s milk protein allergy (CMPA) is the most common food allergy in infancy. CMPA is associated with gut microbial dysbiosis, characterized by low Bifidobacteriaceae levels. This study investigated the impact of a human milk oligosacchari…
View article: Low-no-calorie sweeteners exert marked compound-specific impact on the human gut microbiota <i>ex vivo</i>
Low-no-calorie sweeteners exert marked compound-specific impact on the human gut microbiota <i>ex vivo</i> Open
Low-no-calorie sweeteners (LNCS) are used as sugar substitutes as part of strategies to reduce the risk of chronic diseases related to high sugar intake (e.g. type 2 diabetes (T2D)). This study investigated how a range of sweeteners [tagat…
View article: Carrot RG-I Reduces Interindividual Differences between 24 Adults through Consistent Effects on Gut Microbiota Composition and Function Ex Vivo
Carrot RG-I Reduces Interindividual Differences between 24 Adults through Consistent Effects on Gut Microbiota Composition and Function Ex Vivo Open
The human gut microbiota is characterized by large interpersonal differences, which are not only linked to health and disease but also determine the outcome of nutritional interventions. In line with the growing interest for developing tar…
View article: Bridging preclinical and clinical gut microbiota research using the ex vivo SIFR® technology
Bridging preclinical and clinical gut microbiota research using the ex vivo SIFR® technology Open
Introduction While modulation of the human adult gut microbiota is a trending strategy to improve health, the underlying mechanisms are poorly understood. Methods This study aimed to assess the predictive value of the ex vivo , reactor-bas…
View article: HMOs Exert Marked Bifidogenic Effects on Children’s Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition
HMOs Exert Marked Bifidogenic Effects on Children’s Gut Microbiota Ex Vivo, Due to Age-Related Bifidobacterium Species Composition Open
Prebiotics are substrates that are selectively utilized by host microorganisms, thus conferring a health benefit. There is a growing awareness that interpersonal and age-dependent differences in gut microbiota composition impact prebiotic …
View article: Lacticaseibacillus rhamnosus ATCC 53103 and Limosilactobacillus reuteri ATCC 53608 Synergistically Boost Butyrate Levels upon Tributyrin Administration Ex Vivo
Lacticaseibacillus rhamnosus ATCC 53103 and Limosilactobacillus reuteri ATCC 53608 Synergistically Boost Butyrate Levels upon Tributyrin Administration Ex Vivo Open
Modulation of the gut microbiota is a trending strategy to improve health. While butyrate has been identified as a key health-related microbial metabolite, managing its supply to the host remains challenging. Therefore, this study investig…
View article: Development of a reproducible small intestinal microbiota model and its integration into the SHIME®-system, a dynamic in vitro gut model
Development of a reproducible small intestinal microbiota model and its integration into the SHIME®-system, a dynamic in vitro gut model Open
The human gastrointestinal tract consists of different regions, each characterized by a distinct physiology, anatomy, and microbial community. While the colonic microbiota has received a lot of attention in recent research projects, little…
View article: Serum-Derived Bovine Immunoglobulin Stimulates SCFA Production by Specific Microbes in the Ex Vivo SIFR® Technology
Serum-Derived Bovine Immunoglobulin Stimulates SCFA Production by Specific Microbes in the Ex Vivo SIFR® Technology Open
Serum-derived bovine immunoglobulins (SBI) exert health benefits mediated by their ability to bind microbial components, thereby preventing translocation and subsequent inflammation. While in vivo studies have shown that a fraction of SBI …
View article: Low-no-calorie sweeteners exert marked compound-specific impact on the human gut microbiota <i>ex vivo</i>
Low-no-calorie sweeteners exert marked compound-specific impact on the human gut microbiota <i>ex vivo</i> Open
Low-no-calorie sweeteners (LNCS) are used as sugar substitutes as part of strategies to reduce the risk of chronic diseases related to high sugar intake (e.g. type 2 diabetes (T2D)). This study investigated how a range of sweeteners [tagat…