Stefaan C. De Smedt
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View article: Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation
Pre-formation loading of extracellular vesicles with exogenous molecules using photoporation Open
Despite the natural capacity of extracellular vesicles (EVs) to encapsulate intracellular compounds and transfer these to nearby or distant recipient cells, the intentional loading of EVs with cargo molecules remains a challenging endeavor…
View article: Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways Open
Depending on how antigens are being decoded by dendritic cells (DCs), their acquisition will induce a homeostatic or immunogenic maturation program. This determines how antigens are being presented and whether DCs instruct T cells to induc…
View article: Photothermal transport for guiding nanoparticles through the vitreous humor
Photothermal transport for guiding nanoparticles through the vitreous humor Open
Visual impairments affect over 2.2 billion people worldwide, yet delivering drugs to the eye’s posterior segment, including the retina, remains a major challenge. Intravitreal injection, the standard administration route to the posterior s…
View article: Effective communication with JCR editors in the peer review process
Effective communication with JCR editors in the peer review process Open
View article: Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs
Preclinical toxicological assessment of an α-galactosylceramide-adjuvanted mRNA cancer vaccine in Wistar Han rats and domestic pigs Open
View article: Light-triggered nanocarriers for nucleic acid delivery
Light-triggered nanocarriers for nucleic acid delivery Open
Gene therapy has evolved into a clinically viable strategy, with several approved products demonstrating its therapeutic potential for genetic disorders, cancer, and infectious diseases, and it has ample applications in regenerative medici…
View article: Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells
Photodisruption of the inner limiting membrane promotes retinal engraftment of stem-cell derived retinal ganglion cells Open
Glaucoma is the leading cause of irreversible blindness, driven by the progressive loss of retinal ganglion cells (RGCs). Stem cell-derived RGC transplantation could revolutionize glaucoma treatment, but the inner limiting membrane (ILM) r…
View article: Stability convergence in natural antibodies with ultra-long hypervariable loops
Stability convergence in natural antibodies with ultra-long hypervariable loops Open
Antibodies bind to antigens with hypervariable loops called complementarity-determining regions (CDRs). In contrast to conventional antibodies, a subset of bovine antibodies has an ultra-long CDR (ulCDR) composed of up to 70 residues folde…
View article: Acoustic tweezers for targeted drug delivery
Acoustic tweezers for targeted drug delivery Open
View article: Intrinsic Differential Scanning Fluorimetry for Protein Stability Assessment in Microwell Plates
Intrinsic Differential Scanning Fluorimetry for Protein Stability Assessment in Microwell Plates Open
Intrinsic differential scanning fluorimetry (DSF) is essential for analyzing protein thermal stability. Until now, intrinsic DSF was characterized by medium throughput and high consumable costs. Here, we present a microplate-based intrinsi…
View article: Fading microscopic codes to protect pharmaceuticals from counterfeiting
Fading microscopic codes to protect pharmaceuticals from counterfeiting Open
View article: Development of Propylated Starch-Based Nanoparticles for Amphotericin B Delivery
Development of Propylated Starch-Based Nanoparticles for Amphotericin B Delivery Open
View article: Lipid Nanoparticles as a Tool to Dissect Dendritic Cell Maturation Pathways
Lipid Nanoparticles as a Tool to Dissect Dendritic Cell Maturation Pathways Open
View article: Development of Propylated Starch-Based Nanoparticles for Amphotericin B Delivery
Development of Propylated Starch-Based Nanoparticles for Amphotericin B Delivery Open
View article: Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin‐Loaded Gold Nanoparticles Targeted to the Folate Receptor
Nanosecond Laser Pulses Facilitating Efficient and Specific Cell Killing with Doxorubicin‐Loaded Gold Nanoparticles Targeted to the Folate Receptor Open
Nanoparticle‐based drug carrier systems with active targeting and a controlled release capacity are of considerable interest to bypass side effects of conventional chemotherapy. One appealing approach involves chemotherapeutic‐loaded photo…
View article: Expression of concern: Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters
Expression of concern: Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters Open
Expression of concern for ‘Carbon quantum dots as a dual platform for the inhibition and light-based destruction of collagen fibers: implications for the treatment of eye floaters’ by Alexandre Barras et al. , Nanoscale Horiz. , 2021, 6 , …
View article: Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways
Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways Open
Dendritic cells (DCs) are short-lived immune cells that continuously roam our body in search for foreign or self-antigens. Upon acquisition of antigen, they mature and start migrating to the lymph node to present the antigen to naïve T cel…
View article: Impact of pneumatic tube transportation on the aggregation of monoclonal antibodies in clinical practice
Impact of pneumatic tube transportation on the aggregation of monoclonal antibodies in clinical practice Open
Postproduction handling and in-hospital transportation of antibody drugs cause mechanical stress, including interfacial and shear stress, that can induce antibody unfolding and aggregation. The handling practices differ significantly betwe…
View article: Immunopeptidomics Mapping of Listeria monocytogenes T Cell Epitopes in Mice
Immunopeptidomics Mapping of Listeria monocytogenes T Cell Epitopes in Mice Open
View article: Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria
Alpha-galactosylceramide improves the potency of mRNA LNP vaccines against cancer and intracellular bacteria Open
View article: Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery
Selective Replacement of Cholesterol with Cationic Amphiphilic Drugs Enables the Design of Lipid Nanoparticles with Improved RNA Delivery Open
The delivery of RNA across biological barriers can be achieved by encapsulation in lipid nanoparticles (LNPs). Cationic amphiphilic drugs (CADs) are pharmacologically diverse compounds with ionizable lipid-like features. In this work, we a…
View article: Non-viral delivery of RNA for therapeutic T cell engineering
Non-viral delivery of RNA for therapeutic T cell engineering Open
View article: Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy
Evaluating β2-agonists as siRNA delivery adjuvants for pulmonary surfactant-coated nanogel inhalation therapy Open
View article: Supramolecular dye nanoassemblies for advanced diagnostics and therapies
Supramolecular dye nanoassemblies for advanced diagnostics and therapies Open
Dyes have conventionally been used in medicine for staining cells, tissues, and organelles. Since these compounds are also known as photosensitizers (PSs) which exhibit photoresponsivity upon photon illumination, there is a high desire tow…
View article: Considerations on the Design of Lipid-based mRNA Vaccines Against Cancer
Considerations on the Design of Lipid-based mRNA Vaccines Against Cancer Open
View article: The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments
The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments Open
View article: Dependence of sonoporation efficiency on microbubble size: An in vitro monodisperse microbubble study
Dependence of sonoporation efficiency on microbubble size: An in vitro monodisperse microbubble study Open
Sonoporation is the process where intracellular drug delivery is facilitated by ultrasound-driven microbubble oscillations. Several mechanisms have been proposed to relate microbubble dynamics to sonoporation including shear and normal str…
View article: CO<sub>2</sub>-Driven Nebulization of pH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis
CO<sub>2</sub>-Driven Nebulization of pH-Sensitive Supramolecular Polymers for Intraperitoneal Hydrogel Formation and the Treatment of Peritoneal Metastasis Open
Because peritoneal metastasis (PM) from ovarian cancer is characterized by non-specific symptoms, it is often diagnosed at advanced stages. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) can be considered a promising drug deliver…
View article: Exploring light for advanced drug delivery & surgery in the eye
Exploring light for advanced drug delivery & surgery in the eye Open
View article: Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions
Smart hydrogels delivered by high pressure aerosolization can prevent peritoneal adhesions Open