Stefan Bäurle
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View article: P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal
P2X4 Receptor Antagonist Ameliorates Ocular Pain in Rats After Lacrimal Gland Removal Open
These results suggest that BAY-776 may be a promising option for managing chronic ocular pain.
View article: Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor
Discovery and In Vitro Characterization of BAY 2686013, an Allosteric Small Molecule Antagonist of the Human Pituitary Adenylate Cyclase-Activating Polypeptide Receptor Open
View article: Discovery of <b>BAY-390</b>, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist
Discovery of <b>BAY-390</b>, a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist Open
[Image: see text] Transient receptor potential ankyrin 1 (TRPA1) is a voltage-dependent, ligand-gated ion channel, and activation thereof is linked to a variety of painful conditions. Preclinical studies have demonstrated the role of TRPA1…
View article: CCDC 2008704: Experimental Crystal Structure Determination
CCDC 2008704: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women Open
The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the control of these hormonal effects, ultimately blocking proliferative estrogen signal…
View article: Identification of a Benzimidazolecarboxylic Acid Derivative (<b>BAY 1316957</b>) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis
Identification of a Benzimidazolecarboxylic Acid Derivative (<b>BAY 1316957</b>) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis Open
The presence and growth of endometrial tissue outside the uterine cavity in endometriosis patients are primarily driven by hormone-dependent and inflammatory processes-the latter being frequently associated with severe, acute, and chronic …
View article: Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition
Super-enhancers define a proliferative PGC-1α-expressing melanoma subgroup sensitive to BET inhibition Open