Christiane Schneider‐Gold

Early Versus Delayed Add-on Therapy in Generalized Myasthenia Gravis: A Multicenter Real-World Cohort Study Open

Menekse Oeztuerk, Niklas Huntemann, Lea Gerischer, Sophie Lehnerer, Maike Stein , et al. · 2025

Objective This study examined whether the timing of targeted add-on therapy initiation influences clinical outcomes in acetylcholine receptor (AChR) antibody-positive generalized myasthenia gravis (gMG), based on the hypothesis that earlie…

Cortical thinning and white matter alterations in myotonic dystrophy type 2 over a 10-year period Open

Britta Krieger, Christiane Schneider‐Gold, Erhan Genç, Onur Güntürkün, Christian Prehn , et al. · 2025

Repeat-associated ataxias in a German patient cohort analysed by targeted parallel long-read sequencing Open

Hannes Erdmann, Annalisa Schaub, Morghan C. Lucas, Veronika Scholz, Anna Benet‐Pagès , et al. · 2025

Hereditary adult-onset ataxias are a heterogeneous group of phenotypically overlapping conditions, often caused by pathogenic expansions of short tandem repeats. Currently, 18 repeat disorders with a core phenotype of adult-onset ataxia ar…

C5 complement inhibition versus FcRn modulation in generalised myasthenia gravis Open

Niklas Huntemann, Lea Gerischer, Meret Herdick, Christopher Nelke, Frauke Stascheit , et al. · 2025

Background Myasthenia gravis (MG) is an autoimmune disorder affecting neuromuscular junctions, leading to fluctuating muscle weakness. While many patients respond well to standard immunosuppression, a substantial subgroup faces ongoing dis…

Rapid differentiation of MOGAD and MS after a single optic neuritis Open

Thivya Pakeerathan, Joachim Havla, Carolin Schwake, Anke Salmen, Marius Ringelstein , et al. · 2024

Background Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS) and myelin-oligodendrocyte-glycoprotein IgG-associated disease (MOGAD). This study evaluated the applicability of optical coherence tomography (OCT) for di…

Longitudinal evaluation of polyneuropathy in Parkinson’s disease Open

Eun Hae Kwon, Antonia Bieber, Paula Schülken, Katharina Müller, Eva Kühn , et al. · 2024

Background Increasing evidence indicates a higher prevalence of polyneuropathy (PNP) in Parkinson’s disease (PD). However, the involvement of large fiber neuropathy in PD still remains poorly understood. Given the lack of longitudinal data…

Greater cortical thinning and microstructural integrity loss in myotonic dystrophy type 1 compared to myotonic dystrophy type 2 Open

Britta Krieger, Christiane Schneider‐Gold, Erhan Genç, Onur Güntürkün, Christian Prehn , et al. · 2024

The multiple roles of nerve biopsy in the diagnosis and prognosis of suspected immune neuropathies Open

Rafael Klimas, Anna Kordes, Sophie Huckemann, Zornitsa Gasz, Jörg Philipps , et al. · 2024

Treatment of concomitant myasthenia gravis and Lambert-Eaton myasthenic syndrome with autologous CD19-targeted CAR T cells Open

Jeremias Motte, Melissa Sgodzai, Christiane Schneider‐Gold, Nina K. Steckel, Thomas Mika , et al. · 2024

POLAR: prediction of prolonged mechanical ventilation in patients with myasthenic crisis Open

Dominik Heider, Henning Stetefeld, Andreas Meisel, Julian Bösel, Marie Artho , et al. · 2024

Myasthenia gravis (MG) is a B-cell-mediated autoimmune disease and the most frequent disorder of the neuromuscular junction.Characteristic symptoms are muscle weakness, dysphagia, diplopia and fatigue that typically increase throughout con…

Association of the neonatal Fc receptor promoter variable number of tandem repeat polymorphism with immunoglobulin response in patients with chronic inflammatory demyelinating polyneuropathy Open

Anna Lena Fisse, E Schäfer, Alina Hieke, Maximilian Schröder, Rafael Klimas , et al. · 2024

Background and purpose Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disease with humoral and cellular autoimmunity causing demyelination of peripheral nerves, commonly treated with intravenous immunoglobulins (…

The association of vagal atrophy with parameters of autonomic function in multiple system atrophy and progressive supranuclear palsy Open

Teresa Kleinz, L. Scholz, Sophie Huckemann, Rachel Rohmann, Eva Kühn , et al. · 2024

Background: Vagal atrophy is a hallmark of Parkinson’s disease (PD) and has been found to be associated with autonomic dysfunction, while analyses of the vagus nerve (VN) in atypical Parkinsonian syndromes (APS) have not yet been performed…

Refocusing generalized myasthenia gravis: Patient burden, disease profiles, and the role of evolving therapy Open

Francesco Saccà, Emmanuelle Salort‐Campana, Saiju Jacob, Elena Cortés‐Vicente, Christiane Schneider‐Gold · 2023

Background and purpose Generalized myasthenia gravis (gMG) continues to present significant challenges for clinical management due to an unpredictable disease course, frequent disease fluctuations, and varying response to therapy. The rece…

The emerging spectrum of fetal acetylcholine receptor antibody-related disorders (FARAD) Open

Nicholas M. Allen, Mark O’Rahelly, B. Eymard, Mondher Chouchane, Andreas Hahn , et al. · 2023

In utero exposure to maternal antibodies targeting the fetal acetylcholine receptor isoform (fAChR) can impair fetal movement, leading to arthrogryposis multiplex congenita (AMC). Fetal AChR antibodies have also been implicated in apparent…

Greater Cortical Thinning and Microstructural Integrity Loss in Myotonic Dystrophy Type 1 Compared to Type 2 Open

Britta Krieger, Christiane Schneider‐Gold, Erhan Genç, Onur Güntürkün, Christian Prehn , et al. · 2023

Guideline for the management of myasthenic syndromes Open

Heinz Wiendl, Angela Abicht, Andrew Chan, Adela Della Marina, Tim Hagenacker , et al. · 2023

Myasthenia gravis (MG), Lambert-Eaton myasthenic syndrome (LEMS), and congenital myasthenic syndromes (CMS) represent an etiologically heterogeneous group of (very) rare chronic diseases. MG and LEMS have an autoimmune-mediated etiology, w…

Vagal cross-sectional area correlates with parasympathetic dysfunction in Parkinson's disease Open

Sophie Huckemann, Katharina Mueller, Paulina Averdunk, Eva Kühn, Lovis Hilker , et al. · 2022

The aim of this prospective study was to investigate autonomic function in Parkinson’s disease with a multidimensional approach including clinical evaluation tools, head-up tilt test and morphological studies of the vagus nerve. Head-up ti…

Seronegative myasthenic crisis: a multicenter analysis Open

Philipp Mergenthaler, Henning Stetefeld, Christian Dohmen, Siegfried Köhler, Silvia Schönenberger , et al. · 2022

Improving the understanding of how patients with non-dystrophic myotonia are selected for myotonia treatment with mexiletine (NaMuscla): outcomes of treatment impact using a European Delphi panel Open

Ann-Marie Chapman, Marieke Schurer, L. Weijers, Amer Omar, Hiba Lee , et al. · 2021

Axonal damage determines clinical disability in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): A prospective cohort study of different CIDP subtypes and disease stages Open

Thomas Grüter, Jeremias Motte, Yeşim Bulut, Anna Kordes, Diamantis Athanasopoulos , et al. · 2021

Background and purpose Monitoring of patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is challenging in daily medical practice because the interrelationship between clinical disability, CIDP subtype, and neuro…

Phoenix from the ashes: dramatic improvement in severe late-onset methylenetetrahydrofolate reductase (MTHFR) deficiency with a complete loss of vision Open

Anne‐Sophie Biesalski, Sabine Hoffjan, Ruth Schneider, Huu Phuc Nguyen, Gabriele Dekomien , et al. · 2021

Purpose!#!To calculate the overall incidence of uveal melanoma in Germany and to compare incidences in different German states. In addition, we computed the overall and cancer-specific survival rates nationwide.!##!Methods!#!Incidence data…

Dose-dependent immunomodulatory effects of bortezomib in experimental autoimmune neuritis Open

Rafael Klimas, Melissa Sgodzai, Jeremias Motte, Nuwin Mohamad, Pia Renk , et al. · 2021

Proteasome inhibition with bortezomib has been reported to exert an immunomodulatory action in chronic autoimmune neuropathies. However, bortezomib used for the treatment of multiple myeloma induces a painful toxic polyneuropathy at a high…

Report of a fulminant anti‐<span>pan‐neurofascin</span>‐associated neuropathy responsive to rituximab and bortezomib Open

Miriam Fels, Anna Lena Fisse, Carolin Schwake, Jeremias Motte, Diamantis Athanasopoulos , et al. · 2021

Inflammatory neuropathies with pathogenic involvement of the nodes of Ranvier through autoantibodies have been increasingly characterized in the past years. The so‐called anti‐pan‐NF‐associated neuropathies caused by the simultaneous exist…

COVID-19 mRNA vaccine induced rhabdomyolysis and fasciitis Open

Simon Faissner, Daniel Richter, Ulaş Ceylan, Christiane Schneider‐Gold, Ralf Gold · 2021

Objectives!#!Extracranial stenosis of the internal carotid artery (ICA) is an important cause of ischemic stroke and transient ischemic attack (TIA). It can be diagnosed using contrast-enhanced CT or MR angiography (MRA) as well as Doppler…

Prevalence and Characteristics of Polyneuropathy in Atypical Parkinsonian Syndromes: An Explorative Study Open

Rachel Rohmann, Eva Kühn, Raphael Scherbaum, Lovis Hilker, Saskia Kools , et al. · 2021

(1) Background: Peripheral nerve involvement is increasingly recognized in Parkinson’s disease (PD). Although non-motor symptoms and postural instability are early features of atypical parkinsonian syndromes (APS), peripheral neuropathies …

MuSK-antibodies are associated with worse outcome in myasthenic crisis requiring mechanical ventilation Open

Nicole König, Henning Stetefeld, Christian Dohmen, Philipp Mergenthaler, Siegfried Köhler , et al. · 2021

Evaluation of the EFNS/PNS diagnostic criteria in a cohort of CIDP patients Open

Diamantis Athanasopoulos, Jeremias Motte, Thomas Grüter, N. Köse, Min‐Suk Yoon , et al. · 2021

Objective To evaluate the European Federation of Neurological Societies (EFNS)/Peripheral Nerve Society (PNS) diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP) in a cohort of patients diagnosed and treated fo…

Advances and challenges in the treatment of myasthenia gravis Open

Christiane Schneider‐Gold, Nils Erik Gilhus · 2021

Myasthenia gravis (MG) is a chronic autoimmune disease with fluctuating muscle weakness and fatigability. Standard immunomodulatory treatment may fail to achieve sufficient improvement with minimal symptom expression or remission of myasth…

Treatment response to cyclophosphamide, rituximab, and bortezomib in chronic immune-mediated sensorimotor neuropathies: a retrospective cohort study Open

Jeremias Motte, Anna Lena Fisse, N. Köse, Thomas Grüter, Hannah Mork , et al. · 2021

Background: Up to 20% of patients with chronic immune-mediated sensorimotor neuropathies (CIN) do not respond adequately to first-line therapies. However, studies on further treatment are scarce. Methods: We analyzed retrospectively 200 CI…

Early Tracheostomy Is Associated With Shorter Ventilation Time and Duration of ICU Stay in Patients With Myasthenic Crisis—A Multicenter Analysis Open

Klemens Angstwurm, Amelie Vidal, Henning Stetefeld, Christian Dohmen, Philipp Mergenthaler , et al. · 2020

Background: Myasthenic crisis (MC) requiring mechanical ventilation (MV) is a rare and serious complication of myasthenia gravis. Here we analyzed the frequency of performed tracheostomies, risk factors correlating with a tracheostomy, as …

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