Stefan Fest
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View article: Real-life per- and polyfluoroalkyl substances mixture impairs placental function: insights from a trophoblast spheroid model
Real-life per- and polyfluoroalkyl substances mixture impairs placental function: insights from a trophoblast spheroid model Open
Per- and polyfluoroalkyl substances (PFAS) are persistent endocrine-disrupting chemicals (EDCs) linked to adverse reproductive outcomes. While the placenta is a known target of PFAS toxicity, most in vitro studies use two-dimensional (2D) …
View article: Mast Cells Retard Tumor Growth in Ovarian Cancer: Insights from a Mouse Model
Mast Cells Retard Tumor Growth in Ovarian Cancer: Insights from a Mouse Model Open
Ovarian cancer has the highest mortality rate among female reproductive tract malignancies. A complex network, including the interaction between tumor and immune cells, regulates the tumor microenvironment, survival, and growth. The role o…
View article: Characterization of post-vaccination SARS-CoV-2 T cell subtypes in patients with different hematologic malignancies and treatments
Characterization of post-vaccination SARS-CoV-2 T cell subtypes in patients with different hematologic malignancies and treatments Open
Background To evaluate the benefits of SARS-CoV-2 vaccination in cancer patients it is relevant to understand the adaptive immune response elicited after vaccination. Patients affected by hematologic malignancies are frequently immune-comp…
View article: Characterization of Three-Dimensional Trophoblast Spheroids: An Alternative Model to Study the Physiological Properties of the Placental Unit
Characterization of Three-Dimensional Trophoblast Spheroids: An Alternative Model to Study the Physiological Properties of the Placental Unit Open
It was postulated that 3D cell culture models more accurately reflect the complex tissue physiology and morphology in comparison to 2D cell monolayers. Currently, there is a shortage of well-characterized and easily maintainable high-throu…
View article: Depletion of Foxp3+ regulatory T cells but not the absence of <scp>CD19</scp>+<scp>IL</scp>‐10+ regulatory B cells hinders tumor growth in a para‐orthotopic neuroblastoma mouse model
Depletion of Foxp3+ regulatory T cells but not the absence of <span>CD19</span>+<span>IL</span>‐10+ regulatory B cells hinders tumor growth in a para‐orthotopic neuroblastoma mouse model Open
Adaptive immune cells with regulatory function reportedly mediate immune escape in a variety of tumors. Little is known regarding the relevance of the most prominent regulatory cell populations, namely Foxp3+ T regulatory cells (Tregs) and…
View article: Comorbidity impairs tumor-specific survival of patients with advanced squamous cell carcinoma of the head and neck-region
Comorbidity impairs tumor-specific survival of patients with advanced squamous cell carcinoma of the head and neck-region Open
Introduction Comorbidity influences treatment decision, complication rate and survival of patients suffering from cancer. The negative impact on overall survival (OS), disease-free survival (DFS) and non-cancer-specific survival (NCSS) of …
View article: Extensive complication after elective tonsillectomy
Extensive complication after elective tonsillectomy Open
Introduction Tonsillectomy is one of the most commonly performed procedures of the head and neck surgery and is one of the routine operations of an ENT doctor. Significant complications such as rebleeding may occur.
View article: High-risk Human Papillomavirus (HR-HPV) DNA Detection in Mouth Rinses for Diagnosis of HPV-driven oropharynx cancer
High-risk Human Papillomavirus (HR-HPV) DNA Detection in Mouth Rinses for Diagnosis of HPV-driven oropharynx cancer Open
Background The detection of HPV DNA in mouthwashes has been reported as an alternative to the immunohistochemical detection of p16 in oropharyngeal (OPSCC) and other squamous cell carcinomas of the head and neck region (HNSCC). HPV DNA mig…
View article: Abstract 4570: Selective depletion of regulatory T cells suppressed neuroblastoma tumor growth in mice
Abstract 4570: Selective depletion of regulatory T cells suppressed neuroblastoma tumor growth in mice Open
Purpose of the studyNeuroblastoma (NB) is the most common solid extracranial tumor in childhood. Regulatory T cells (Treg) are known to have immune suppressive capacity and to be involved in tolerance establishment. As they support tumor g…
View article: Abstract 4559: Tumor-derived Galectin-1 promotes tumor growth in an orthotopic C57Bl/6 NB mouse model
Abstract 4559: Tumor-derived Galectin-1 promotes tumor growth in an orthotopic C57Bl/6 NB mouse model Open
QuestionWe recently introduced the carbohydrate-binding protein Galectin-1 (Gal-1) as a novel tolerogeneic molecule in neuroblastoma (NB). NB-secreted Gal-1 suppressed the maturation of dendritic cells (DC) and inhibited T cell function. H…
View article: A rare differential diagnosis of dysphagia
A rare differential diagnosis of dysphagia Open
Dysphagia can occur in all life decades. Exsiccosis, malnutrition or even aspiration pneumonia are possible consequences of dysphagia. The reasons of a disturbed swallowing act are very diverse: tumors of the upper gastrointestinal tract, …
View article: A rare differential diagnosis of subglottic stenosis
A rare differential diagnosis of subglottic stenosis Open
Primary involvement of the larynx in non-Hodgkin's lymphoma (NHL) is rare. They represent < 1% of all laryngeal tumors. Usually laryngeal NHL occurs in the supraglottic area sometimes compared with infiltration of the glottic part. Primary…
View article: Does dietary intervention improve progression-free survival of curatively treated advanced HNSCC patients?
Does dietary intervention improve progression-free survival of curatively treated advanced HNSCC patients? Open
Mediterranean nutrition in epidemiological trials showed to be protective against head and neck squamous cell carcinoma (HNSCC). TRANSCAN DietINT is a randomised phase II trial for tertiary prevention of HNSCC using dietary intervention to…
View article: Targeting of heme oxygenase‐1 as a novel immune regulator of neuroblastoma
Targeting of heme oxygenase‐1 as a novel immune regulator of neuroblastoma Open
Heme oxygenase (HO)−1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common…
View article: Heme oxygenase-1 is critically involved in placentation, spiral artery remodeling, and blood pressure regulation during murine pregnancy
Heme oxygenase-1 is critically involved in placentation, spiral artery remodeling, and blood pressure regulation during murine pregnancy Open
The onset of pregnancy implies the appearance of a new organ, the placenta. One main function of the placenta is to supply oxygen to the fetus via hemoproteins. In this review, we highlight the importance of the enzyme heme oxygenase-1 (HO…