Ioan Ştefan Florian
YOU?
Author Swipe
A dual-axis cisternal classification for congenital intracranial cystic lesions: implications for surgical strategy and long-term prognosis Open
Background Congenital intracranial cystic lesions—epidermoid, dermoid, neurenteric, Rathke, colloid—encompass a heterogeneous group of entities whose surgical behavior is only partly explained by histology. We propose a dual-axis cisternal…
A Comprehensive Analysis of the Management of Brain Metastases—Experience from a South-Eastern European Neurosurgical Centre Open
Background: Brain metastases represent the most common intracranial tumours in cancer patients, with no consensus on surgical outcomes and prognostic factors. This study aimed to analyse the demographic, clinical, and tumour-related factor…
Surgical resection for multiple brain metastases: a systematic review and meta-analysis of functional and survival outcomes Open
Background. Brain metastases (BMs) are the most common intracranial tumors among adults, which exceed primary brain tumors by far. Surgery and radiotherapy represent the key local management of BM. However, the exact role of surgery is sti…
View article: Cerebral Vascular Disturbances Following Traumatic Brain Injury: Pathophysiology, Diagnosis, and Therapeutic Perspectives—A Narrative Review
Cerebral Vascular Disturbances Following Traumatic Brain Injury: Pathophysiology, Diagnosis, and Therapeutic Perspectives—A Narrative Review Open
Traumatic brain injury (TBI) is a major global health concern and a leading cause of long-term disability and mortality. While the primary mechanical insult is often the focus of acute care, secondary injury mechanisms—particularly cerebro…
Endothelial transdifferentiation of glioma stem cells: a literature review Open
Endothelial transdifferentiation represents a multifaceted process wherein glioma stem cells (GSCs) gradually adopt endothelial characteristics, marked by the expression of endothelial markers (CD31, CD34) and functional traits, while conc…
Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study Open
Background and Objectives: Over 30% of people who suffer from cancers are at risk of developing brain metastases. The typical recommended surgical therapy for metastases within the brain is gross total resection (GTR). Nevertheless, GTR so…
Assessing Acute DWI Lesions in Clinically Diagnosed TIA: Insights from a Cohort Study in Cluj, Romania Open
Background: The updated definition of a TIA emphasizes tissue characteristics rather than symptom duration, defining a TIA as a transient neurological episode without ischemic lesions in brain imaging, including in DWI. If imaging reveals …
Optimizing Surgical Management of Anterior Skull Base Meningiomas: Imaging Modalities, Key Surgical Considerations, and Risk Mitigation Strategies Open
Skull base meningiomas present considerable challenges in surgical management due to their proximity to critical neurovascular structures. Anterior skull base meningiomas encompass olfactory groove, supra- and parasellar, anterior sphenoid…
Assessing DWI Positivity in Clinically Diagnosed TIA: Insights from a Cohort Study in Cluj, Romania Open
The updated definition of TIA emphasizes tissue characteristics rather than symptom duration, defining TIA as a transient neurological episode without ischemic lesions on brain imaging, including DWI. If imaging reveals a lesion, even in p…
Hypothesis: Is Dura Mater the True Culprit Behind Chiari 1 Malformations? Open
In this article, we discuss the theory that an error in dural development and/or signaling is responsible for the occurrence of Chiari 1 Malformations (CM1). Other widely accepted theories such as the premature closure of the spheno-occipi…
Implausible, not impossible: delayed supradiaphragmatic thoracic migration of a ventriculoperitoneal shunt in a 17-month-old Open
Background Intrathoracic migration of a ventriculoperitoneal shunt (VPS) is a phenomenally rare complication, with the supradiaphragmatic intercostal variant even more so. Whereas it can prove debilitating or even fatal via massive hydroth…
The Nightmare of AVM Surgery: Early Rupture of the Venous Drainage—Lessons from Personal Experience and a Review of the Literature Open
We describe the case of a 72-year-old man who presented with signs of increased intracranial pressure, right-sided motor deficit, and repeated episodes of epilepsy due to a left frontal arteriovenous malformation (AVM) with a large superfi…
A SPINAL TRAUMA, A TUMOR AND EVERYTHING IN BETWEEN Open
Introduction Burkitt lymphoma is a male predominant (3:1 male:female ratio) aggressive B-cell non-Hodgkin lymphoma that can present as a sporadic variant with meningeal involvement in about 20% of cases. Therefore, it can manifest with neu…
NOT THE USUAL SUSPECTS: GLIOBLASTOMA OF THE CEREBELLOPONTINE ANGLE MASQUERADING AS A VESTIBULAR SCHWANNOMA Open
Introduction Most tumoral processes involving the cerebellopontine angle (CPA) are extraneuraxial and usually comprise of vestibular schwannomas and meningiomas, followed by less common lesions such as epidermoid cysts, metastases and arac…
INTRACRANIAL ARTERIAL LOOP WITH A COMPLEX PARTIALLY THROMBOSED LARGE ANEURYSM ON THE POSTERIOR CIRCULATION: WHAT TO DO NEXT? Open
Introduction Managing intracranial aneurysms in the posterior circulation is particularly challenging due to anatomical complexities and the high risk of rupture. The presence of a large, partially thrombosed aneurysm adds another layer of…
View article: IN VIVO INOCULATION OF GBM CELLS IN RATS AND TREATMENT WITH RUXOLITINIB
IN VIVO INOCULATION OF GBM CELLS IN RATS AND TREATMENT WITH RUXOLITINIB Open
GlioStat (patent pending) denotes an invention that addresses the current deficiencies of glioblastoma (GBM) chemotherapy by developing a molecularly imprinted drug reservoir that is specifically designed for post-surgical recovery. The go…
Outcomes and Complications of Posterior Fossa Surgery in Sitting Versus Park-Bench Positions Open
Background/Objectives: Patient positioning during surgery can influence intra- and postoperative complications. Therefore, we assessed the impact of the sitting and park-bench positions on anesthetic parameters and complications in neurosu…
Exploring anesthesia-related complications in pediatric neurosurgery: a comparative analysis of the sitting and park-bench positions Open
Background and aims. The purpose of this study is to analyze the sitting position and the park-bench position for intra-anesthesia complications in pediatric patients undergoing neurosurgery for posterior fossa lesions. Our goal is to high…
Influence of Patient Position-Related Differences in Intra- and Postoperative Implications on Major Anesthesia Parameters in Posterior Fossa Surgery Open
Background/Objectives: Patient positioning during surgery can influence intra- and postoperative complications. Therefore, we assessed the impact of the sitting and park-bench positions on anesthetic parameters and complications in neurosu…
Tumor-Like Lesions in the Craniovertebral Junction: A Case Series, Systematic Review, and Meta-Analysis Open
Background: Tumor-like lesions at the craniovertebral junction mimic tumors in clinical presentation and imaging. Our study focuses on three common developmental pathologies—epidermoids, dermoids and neurenteric cysts. Methods: We conducte…
View article: Posttraumatic hydrocephalus as a complication of decompressive craniectomy–same old story, new perspectives
Posttraumatic hydrocephalus as a complication of decompressive craniectomy–same old story, new perspectives Open
Objective Decompressive craniectomy (DC) serves as a vital life-saving intervention, demonstrating efficacy in reducing intracranial pressure (ICP). However, its efficacy hinges on meticulous surgical execution, perioperative management, a…
The impact of arachnoid structures on skull-base meningioma surgical management: a radiological analysis and narrative review Open
The presence of intact arachnoid membranes between skull base meningiomas and critical neurovascular structures is crucial for predicting surgical outcomes, understanding tumor development and growth, and planning the feasibility of tumor …
Magnetic Resonance Imaging Features of the Sphenoid Sinus in Patients with Non-Functioning Pituitary Adenoma Open
Background and Objectives: A magnetic resonance imaging (MRI) scan is part of the diagnostic protocol in pituitary adenoma patients. The goal of the present study is to present and analyse the MRI appearances of the sphenoid sinus (SS) in …
Anastomosis between the facial nerve – ansa cervicalis and the facial nerve – hypoglossal nerve in rabbits: technical note for a practical use in peripheral facial palsy Open
Background and aims. To emphasize the importance of laboratory dissections in perfecting surgical techniques. In this paper, we describe the technical details on rabbit dissection for practical applications. Methods. Four New Zealand rabbi…
White matter changes in fetal brains with ventriculomegaly Open
Introduction Ventriculomegaly (VM) is a fetal brain malformation which may present independently (isolated form) or in association with different cerebral malformations, genetic syndromes or other pathologies (non-isolated form). Methods T…
Intracranial epidermoid cysts: benign entities with malignant behavior: experience with 36 cases Open
Intracranial epidermoid cysts are benign slow-growing ectodermal inclusions that account for less than 1% of all intracranial tumors. We retrospectively reviewed 36 such cases to evaluate the demographic characteristics, clinical manifesta…
Intracranial arteriovenous malformation (AVM) or meningothelial meningioma (MM)? Outlining the similarities and differences on imaging studies for an accurate diagnosis, case report Open
Acquiring neuro-radiological expertise is vital for the neurosurgeon, as well as fast ability for adjusting the initial action plan with the intraoperative discoveries. An experienced eye can benefit the patient by obtain a correct diagnos…