Explanipedia

Long-term effects of medical treatment in patients with chronic thromboembolic pulmonary hypertension Open

Marion Delcroix, Iréne Lang, Andrea Maria D’Armini, Élie Fadel, Stefan Guth , et al. · 2025

Background The New International Chronic Thromboembolic Pulmonary Hypertension (CTEPH) Registry, conducted between 2015 and 2019, revealed the significant impact of pulmonary endarterectomy (PEA) and balloon pulmonary angioplasty (BPA) on …

Transcriptional changes of the extracellular matrix in chronic thromboembolic pulmonary hypertension govern right ventricle remodeling and recovery Open

Leili Jafari, Christoph B. Wiedenroth, Steffen Kriechbaum, Dimitri Grün, Prakash Chelladurai , et al. · 2025

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension Open

Iréne Lang, Philippe Brénot, Hélène Bouvaist, Élie Fadel, Xavier Jaïs , et al. · 2025

Our data are in line with previous reports on changes of clinical and hemodynamic parameters and complication rates of BPA. Centers with more experience providing BPAs were more likely to achieve a higher percentage decrease in PVR.

The Diagnostic Accuracy of an Electrocardiogram in Pulmonary Hypertension and the Role of “R V1, V2 + S I, aVL − S V1” Open

Lukas Ley, Christoph B. Wiedenroth, Stefan Guth, Christian Gold, Athiththan Yogeswaran , et al. · 2024

Background: Pulmonary hypertension (PH) can cause characteristic electrocardiographic (ECG) changes due to right ventricular hypertrophy and/or strain. The aims of the present study were to explore the diagnostic accuracy of ECG parameters…

Worldwide CTEPH Registry: Long-Term Outcomes With Pulmonary Endarterectomy, Balloon Pulmonary Angioplasty, and Medical Therapy Open

Marion Delcroix, Joanna Pepke‐Żaba, Andrea Maria D’Armini, Élie Fadel, Stefan Guth , et al. · 2024

BACKGROUND: The European Chronic Thromboembolic Pulmonary Hypertension (CTEPH) registry, conducted between 2007 and 2012, reported the major impact of pulmonary endarterectomy (PEA) on the long-term survival of patients with CTEPH. Since t…

A common gene signature of the right ventricle in failing rat and human hearts Open

Liane Jurida, Sebastian Werner, Fabienne Knapp, Bernd Niemann, Ling Li , et al. · 2024

Native hepatic T1-time as a non-invasive predictor of diastolic dysfunction and a monitoring tool for disease progression and treatment response in patients with pulmonary hypertension Open

Nils Kremer, Fritz Roller, Sarah Kremer, Simon Schäfer, Vitalii Kryvenko , et al. · 2024

Hepatic T1-time predicts RV diastolic dysfunction and prognosis, and may be useful for monitoring disease progression and treatment response in PH.

Native Hepatic T1-Time as a Non-Invasive Predictor of Diastolic Dysfunction and a Monitoring Tool for Disease Progression and Treatment Response in Patients with Pulmonary Hypertension Open

Nils Kremer, Fritz Roller, Sarah Kremer, Simon Schäfer, Vitalii Kryvenko , et al. · 2024

Chronisch thromboembolische pulmonale Hypertonie (Gruppe 4) Open

Stefan Guth, Heinrike Wilkens, Michael Halank, Matthias Held, Lukas Hobohm , et al. · 2023

Zusammenfassung Die chronisch thromboembolische Lungengefäßerkrankung (CTEPD) ist eine wichtige Spätfolge der akuten Lungenembolie, bei der die Thromben in fibröses Gewebe transformiert werden, mit der Gefäßwand verwachsen und zu chronisch…

Zusammenfassung und Kommentierung der neuen europäischen Leitlinie zum Lungenhochdruck Open

Ekkehard Grünig, Nicola Benjamin, Jürgen Behr, Dirk Skowasch, Katrin Milger , et al. · 2023

Die Novemberausgabe Pneumologie widmet sich der Zusammenfassung und Kommentierung der neuen europäischen Leitlinien zur pulmonalen Hypertonie (PH) [1], einem bedeutsamen, häufig erst spät diagnostizierten Krankheitsbild, bei dem in den let…

Endothelial Overexpression of TGF-β-Induced Protein Impairs Venous Thrombus Resolution Open

Magdalena L. Bochenek, Kathrin Saar, Maliheh Nazari-Jahantigh, Rajinikanth Gogiraju, Christoph B. Wiedenroth , et al. · 2023

Endothelial cells play a critical role during venous thrombus remodeling, and unresolved, fibrotic thrombi with irregular vessels obstruct the pulmonary artery in patients with chronic thromboembolic pulmonary hypertension (CTEPH). This st…

Patient-Reported Long-Term Outcome of Balloon Pulmonary Angioplasty for Inoperable CTEPH Open

Christoph B. Wiedenroth, Kristin Steinhaus, Andreas Rolf, Andreas Breithecker, Miriam S. D. Adameit , et al. · 2023

Background Balloon pulmonary angioplasty (BPA) is a promising interventional treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH). Evidence in favor of BPA is growing, but long-term data remain scarce. The Cambrid…

Evaluation of diagnostic accuracy of dual-energy computed tomography in patients with chronic thromboembolic pulmonary hypertension compared to V/Q-SPECT and pulmonary angiogram Open

Armin Schüßler, Quirin Lug, Nils Kremer, Sebastian Harth, Steffen D. Kriechbaum , et al. · 2023

Purpose The relevance of dual-energy computed tomography (DECT) for the detection of chronic thromboembolic pulmonary hypertension (CTEPH) still lies behind V/Q-SPECT in current clinical guidelines. Therefore, our study aimed to assess the…

A common gene signature of the right ventricle in failing rat and human hearts Open

Liane Jurida, Sebastian Werner, Fabienne Knapp, Bernd Niemann, Ling Li , et al. · 2023

Summary The molecular mechanisms of progressive right heart failure are incompletely understood. We systematically compared rat models of pulmonary artery or aortic banding to identify the transcriptomic changes that occur over months in t…

Successful simultaneous stenting of a pulmonary artery and vein in pulmonary vascular stenosis due to silicosis. Case report and literature review Open

Michael Westhoff, Thorsten Hardebusch, P Litterst, Andreas Breithecker, Matilda Haas , et al. · 2023

A 58-year-old patient was admitted to the emergency department due to severe respiratory insufficiency. Anamnesis revealed that the patient had experienced increasing stress dyspnea for a few months. Upon imaging, an acute pulmonary emboli…

Value of Right and Left Ventricular T1 and T2 Blood Pool Mapping in Patients with Chronic Thromboembolic Hypertension before and after Balloon Pulmonary Angioplasty Open

Fritz Roller, Armin Schüßler, Nils Kremer, Sebastian Harth, Steffen D. Kriechbaum , et al. · 2023

Background: Parametric imaging has taken a steep rise in recent years and non-cardiac applications are of increasing interest. Therefore, the aim of our study was to assess right (RV) and left ventricular (LV) blood pool T1 and T2 values i…

Fibroblast growth factor 23 as a biomarker of right ventricular dysfunction in pulmonary hypertension Open

Laila Widmann, Stanislav Keranov, Leili Jafari, Christoph Liebetrau, Till Keller , et al. · 2023

Highlights from the International Chronic Thromboembolic Pulmonary Hypertension Congress 2021 Open

Gérald Simonneau, Élie Fadel, Anton Vonk Noordegraaf, Mark Toshner, Iréne Lang , et al. · 2023

Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare complication of acute pulmonary embolism. It is caused by persistent obstruction of pulmonary arteries by chronic organised fibrotic clots, despite adequate anticoagulation. T…

Right Ventricular Strain by Magnetic Resonance Feature Tracking Is Largely Afterload-Dependent and Does Not Reflect Contractility: Validation by Combined Volumetry and Invasive Pressure Tracings Open

Andreas Rolf, Till Keller, Jan Sebastian Wolter, Steffen D. Kriechbaum, Maren Weferling , et al. · 2022

Cardiac magnetic resonance (CMR) is currently the gold standard for evaluating right ventricular (RV) function, which is critical in patients with pulmonary hypertension. CMR feature-tracking (FT) strain analysis has emerged as a technique…

Exercise MR-proANP unmasks latent right heart failure in CTEPH Open

Steffen D. Kriechbaum, J Birmes, Christoph B. Wiedenroth, D Gruen, Julia Vietheer , et al. · 2022

Background Chronic right heart failure is the major determinant of outcome in chronic thromboembolic pulmonary hypertension (CTEPH). Thus, its early detection is crucial for optimal patient management. Hemodynamic assessment with invasive …

Riociguat and balloon pulmonary angioplasty improve prognosis in patients with inoperable chronic thromboembolic pulmonary Hypertension Open

Christoph B. Wiedenroth, Andreas Rolf, Kristin Steinhaus, Miriam S. D. Adameit, Steffen D. Kriechbaum , et al. · 2022

The combination of riociguat and BPA for the treatment of inoperable CTEPH is associated with excellent 5-year survival rates.

Chronic Lung Allograft Dysfunction Is Associated with Increased Levels of Cell-Free Mitochondrial DNA in Bronchoalveolar Lavage Fluid of Lung Transplant Recipients Open

Emmanuel Schneck, Ingolf Askevold, Ramona Rath, Andreas Hecker, Martin Reichert , et al. · 2022

Chronic Lung Allograft Dysfunction (CLAD) is a life-threatening complication that limits the long-term survival of lung transplantation patients. Early diagnosis remains the basis of efficient management of CLAD, making the need for distin…

The Nuclear Landscape as a Garden Open

Stefan Guth · 2022

Nuclear energy, today often associated with devastating environmental catastrophes, inspired promethean imaginaries of large-scale nature improvement in the postwar heydays of high-modern optimism. Fuel-reproducing fast breeder reactors (F…

Pulmonary endarterectomy: technique and pitfalls Open

Stefan Guth, Eckhard Mayer, Diethard Prüfer, Christoph B. Wiedenroth · 2022

Chronic thromboembolic pulmonary hypertension (CTEPH) remains a rare and underdiagnosed disease. After one or several episodes of acute pulmonary embolism, around 3% of patients develop CTEPH and two-thirds of these patients are potential …

Pulmonary endarterectomy reoperation: frequency, risk factors and outcomes Open

Stefan Guth, Christoph B. Wiedenroth, Eckhard Mayer · 2021

Pulmonary endarterectomy reoperation: frequency, risk factors and outcomes Stefan Guth, Christoph B. Wiedenroth, Eckhard Mayer

Neuroprotective effects of dynamic bubble trap use in patients undergoing pulmonary endarterectomy: a two-arm randomized controlled trial Open

Jasmin El Shazly, Tibo Gerriets, Jürgen Hennig, Marius Butz, Sabrina Kastaun , et al. · 2021

This study is registered in the German Clinical Trials Register, ID: DRKS00021499.

Cardiac biomarkers as indicators of right ventricular dysfunction and recovery in chronic thromboembolic pulmonary hypertension patients after balloon pulmonary angioplasty therapy – a cardiac magnetic resonance imaging cohort study Open

Steffen D. Kriechbaum, Julia Vietheer, Christoph B. Wiedenroth, Felix Rudolph, Marta Barde , et al. · 2021

Background In chronic thromboembolic pulmonary hypertension, right heart failure determines outcome. Balloon pulmonary angioplasty therapy allows right heart recovery, which can be monitored by cardiac magnetic resonance imaging. This stud…

Exercise Hemodynamic Profiling Is Associated With Outcome in Patients Undergoing Percutaneous Mitral Valve Repair Open

Andreas Rieth, Steffen Kriechbaum, Manuel J. Richter, Elena Wenninger, Ulrich Fischer‐Rasokat , et al. · 2021

Background: Percutaneous mitral valve repair (PMVR) in high-risk patients is currently controversial, especially in those with secondary mitral regurgitation (MR). Exercise pulmonary hemodynamics may help to unmask cardiac dysfunction as w…

Current strategies for managing chronic thromboembolic pulmonary hypertension: results of the worldwide prospective CTEPH Registry Open

Stefan Guth, Andrea Maria D’Armini, Marion Delcroix, Kazuhiko Nakayama, Élie Fadel , et al. · 2021

Background Pulmonary endarterectomy (PEA), pulmonary arterial hypertension (PAH) therapy and balloon pulmonary angioplasty (BPA) are currently accepted therapies for chronic thromboembolic pulmonary hypertension (CTEPH). This international…

Role of angiopoietin-2 in venous thrombus resolution and chronic thromboembolic disease Open

Lukas Hobohm, Sebastian Kölmel, Caroline Niemann, Philipp Kümpers, Valentin J. Krieg , et al. · 2021

Background Defective angiogenesis, incomplete thrombus revascularisation and fibrosis are considered critical pathomechanisms of chronic thromboembolic pulmonary hypertension (CTEPH) after pulmonary embolism. Angiopoietin-2 (ANGPT2) has be…

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