Stefan H. Bossmann
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View article: EXTH-116. Potent anti-tumor efficacy of B7-H3 CAR-T cells in H3G34-mutant Diffuse Hemispheric Gliomas
EXTH-116. Potent anti-tumor efficacy of B7-H3 CAR-T cells in H3G34-mutant Diffuse Hemispheric Gliomas Open
Diffuse hemispheric glioma (DHG) harboring H3G34R/V mutations is a devastating pediatric high-grade glioma subtype with no effective treatment and poor prognosis. In response to this critical unmet need, we evaluated B7-H3-targeted chimeri…
View article: SAT-289 Rationally designed cholesterol coated peptide NS as a novel therapeutic strategy in the management of Adrenocortical Carcinoma
SAT-289 Rationally designed cholesterol coated peptide NS as a novel therapeutic strategy in the management of Adrenocortical Carcinoma Open
Disclosure: M. Hassany: None. R. Challapalli: None. O. Covarrubias-Zambrano: None. S. Feely: None. S. Fiachetti: None. M. Luconi: None. M. O'Halloran: None. C. Hantel: None. P. Prakash: None. S. Bossmann: None. M.C. Dennedy: None. Manageme…
View article: Compensatory roles of STT3A and ALG5 in glucose metabolism of aged macaque hippocampus
Compensatory roles of STT3A and ALG5 in glucose metabolism of aged macaque hippocampus Open
The hippocampus (HPC), a central hub for memory and cognition, exhibits unique metabolic resilience during ageing despite widespread brain glucose hypometabolism. Here, we report that aged humans and macaques paradoxically display elevated…
View article: Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells
Targeted nanoencapsulation of tunicamycin reduces toxicity while improving its therapeutic effectiveness in pancreatic cancer cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed b…
View article: Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model
Iron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model Open
ACC cells actively internalise IONPs without significant impairment of viability or steroidogenesis at pharmacologically relevant concentrations. However, non-specific uptake by monocytes and endothelial cells reduces delivery efficiency. …
View article: Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells
Targeted Nanoencapsulation of Tunicamycin Reduces Toxicity While Improving its Therapeutic Effectiveness in Pancreatic Cancer Cells Open
Pancreatic ductal adenocarcinoma (PDAC) remains one of the leading sources of cancer mortality worldwide. An initial response to chemotherapy, such as Gemcitabine (GEM) alone or in combination with other chemotherapies, is often followed b…
View article: Advances in glyconanotechnology based biomedical applications
Advances in glyconanotechnology based biomedical applications Open
There is an emerging awareness in cancer biology that glycobiology plays a significant, if not decisive role in oncogenesis, tumor survival, and proliferation. The human glycome is even more complex than the human genome, because glycans a…
View article: Few-Layer Graphene-Based Optical Nanobiosensors for the Early-Stage Detection of Ovarian Cancer Using Liquid Biopsy and an Active Learning Strategy
Few-Layer Graphene-Based Optical Nanobiosensors for the Early-Stage Detection of Ovarian Cancer Using Liquid Biopsy and an Active Learning Strategy Open
Ovarian cancer survival depends strongly on the time of diagnosis. Detection at stage 1 must be the goal of liquid biopsies for ovarian cancer detection. We report the development and validation of graphene-based optical nanobiosensors (G-…
View article: Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles
Adrenocortical Cancer Cell uptake of Iron Oxide Nanoparticles Open
Adrenocortical carcinoma (ACC) is a rare cancer with poor prognosis, treated primarily through surgery and chemotherapy. Other treatments like radiation or thermal ablation for metastases have limited success, and recurrence is common. Mor…
View article: DDDR-35. THERAPEUTIC STRATEGIES FOR DIFFUSE MIDLINE GLIOMA: INSIGHTS FROM HIGH-THROUGHPUT COMBINATION DRUG AND RADIATION SENSITIZATION SCREENING
DDDR-35. THERAPEUTIC STRATEGIES FOR DIFFUSE MIDLINE GLIOMA: INSIGHTS FROM HIGH-THROUGHPUT COMBINATION DRUG AND RADIATION SENSITIZATION SCREENING Open
Diffuse midline gliomas (DMGs) are the most aggressive pediatric high-grade gliomas. Over 85% DMGs harboring the H3K27M mutation in histone genes H3F3A (H3.3) and H3C2 (H3.1). H3K27M mutation disrupts epigenetic regulation by inhibiting PR…
View article: Tracking Small Extracellular Vesicles Using a Minimally Invasive PicoGreen Labeling Strategy
Tracking Small Extracellular Vesicles Using a Minimally Invasive PicoGreen Labeling Strategy Open
Extracellular vesicles (EVs) are cell-secreted lipid bilayer delimited particles that mediate cellular communication. These tiny sacs of cellular information play an important role in cell communication and alter the physiological process …
View article: 8543 Non-Specific Uptake Of Magnetic Iron Oxide Nanoparticles Into Adrenocortical Carcinoma Cells, Endothelium And Primary Monocytes
8543 Non-Specific Uptake Of Magnetic Iron Oxide Nanoparticles Into Adrenocortical Carcinoma Cells, Endothelium And Primary Monocytes Open
Disclosure: R. Challapalli: None. A. Sorushanova: None. C. Hong: None. N.J. Mullen: None. S. Feely: None. O. Covarrubias-Zambrano: None. J. Covarrubias: None. S. Varghese: None. C. Hantel: None. P. Owens: None. M. O’Halloran: None. P. Prak…
View article: Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer
Selective targeting of IRAK1 attenuates low molecular weight hyaluronic acid-induced stemness and non-canonical STAT3 activation in epithelial ovarian cancer Open
Advanced epithelial ovarian cancer (EOC) survival rates are dishearteningly low, with ~25% surviving beyond 5 years. Evidence suggests that cancer stem cells contribute to acquired chemoresistance and tumor recurrence. Here, we show that I…
View article: Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies
Characterization of a Biochemical Mouse Model of Primary Aldosteronism for Thermal Therapies Open
Introduction Aldosterone-producing adenoma (APA) is the most common cause of endocrine-related hypertension but surgery is not always feasible. Current medical interventions are associated with significant side effects and poor patient com…
View article: Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings
Region-Specific Brain Volume Changes Emerge in Adolescence in the Valproic Acid Model of Autism and Parallel Human Findings Open
Introduction: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication deficits, cognitive dysfunction, and stereotyped repetitive behaviors. Regional volume changes are commonly observed in…
View article: Description of an activity-based enzyme biosensor for lung cancer detection
Description of an activity-based enzyme biosensor for lung cancer detection Open
Background Lung cancer is associated with the greatest cancer mortality as it typically presents with incurable distributed disease. Biomarkers relevant to risk assessment for the detection of lung cancer continue to be a challenge because…
View article: Protease activity-based nanobiosensors for early detection of pancreatic cancer
Protease activity-based nanobiosensors for early detection of pancreatic cancer Open
Five-year survival rate for pancreatic cancer patients has increased to 12.8% after the initial diagnosis, still making it one of the deadliest cancer types. This disease is known as the “silent killer” because early detection is challengi…
View article: Anti-apoptotic Proteolysis Targeted Chimeras (PROTACs) in Cancer Therapy
Anti-apoptotic Proteolysis Targeted Chimeras (PROTACs) in Cancer Therapy Open
Targeted protein degradation is an emerging approach for novel drug discovery and basic research. Several degrader molecules have been developed including PROteolysis-TArgeting Chimeras (PROTACs), specific and nongenetic Inhibitor of APopt…
View article: Graphene nanosheets from the controlled explosion of aromatic hydrocarbons
Graphene nanosheets from the controlled explosion of aromatic hydrocarbons Open
Explosions of benzene, toluene and xylenes were carried out in a 16.7 L chamber in the presence of O2 at different fuel-rich molar ratios such that an aerosol of elemental carbon was produced. The product was a powder at higher precursor o…
View article: Repurposing sunscreen as an antibiotic: zinc-activated avobenzone inhibits methicillin-resistant <i>Staphylococcus aureus</i>
Repurposing sunscreen as an antibiotic: zinc-activated avobenzone inhibits methicillin-resistant <i>Staphylococcus aureus</i> Open
Methicillin-resistant Staphylococcus aureus (MRSA) is a major healthcare concern with associated healthcare costs reaching over ${\$}$1 billion in a single year in the USA. Antibiotic resistance in S. aureus is now observed against last li…
View article: Super-resolution reconstruction in ultrahigh-field MRI
Super-resolution reconstruction in ultrahigh-field MRI Open
Magnetic resonance imaging (MRI) is a highly significant imaging platform for a variety of medical and research applications. However, the low spatiotemporal resolution of conventional MRI limits its applicability toward rapid acquisition …
View article: Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer
Anticancer Activity of Novel Difluorinated Curcumin Analog and Its Inclusion Complex with 2-Hydroxypropyl-β-Cyclodextrin against Pancreatic Cancer Open
Pancreatic ductal adenocarcinoma (PDAC) is the primary reason for cancer-related deaths in the US. Genetic mutations, drug resistance, the involvement of multiple signaling pathways, cancer stem cells (CSCs), and desmoplastic stroma, which…
View article: In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells
In Vitro Measurement and Mathematical Modeling of Thermally-Induced Injury in Pancreatic Cancer Cells Open
Thermal therapies are under investigation as part of multi-modality strategies for the treatment of pancreatic cancer. In the present study, we determined the kinetics of thermal injury to pancreatic cancer cells in vitro and evaluated pre…