Stefan Hamann
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View article: Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice
Antisense Oligonucleotide-Mediated Reduction of HDAC6 Does Not Reduce Tau Pathology in P301S Tau Transgenic Mice Open
Acetylation of tau protein is dysregulated in Alzheimer's Disease (AD). It has been proposed that acetylation of specific sites in the KXGS motif of tau can regulate phosphorylation of nearby residues and reduce the propensity of tau to ag…
View article: RNA tape sampling in cutaneous lupus erythematosus discriminates affected from unaffected and healthy volunteer skin
RNA tape sampling in cutaneous lupus erythematosus discriminates affected from unaffected and healthy volunteer skin Open
Objective Punch biopsy, a standard diagnostic procedure for patients with cutaneous lupus erythematosus (CLE) carries an infection risk, is invasive, uncomfortable and potentially scarring, and impedes patient recruitment in clinical trial…
View article: Minimality conditions for convex composite functions and an application in vector optimization
Minimality conditions for convex composite functions and an application in vector optimization Open
We prove both necessary and sufficient conditions for weak sharp minima of convex composite functions, where the latter requires neither the (lower semi-)continuity of the convex function nor the restriction on Banach spaces, and permits a…
View article: P4‐058: A NOVEL TRANSGENIC RAT MODEL THAT PRESENTS PATHOPHYSIOLOGICAL LEVELS OF HUMAN TAU IN CSF, AXONOPATHY, HIPPOCAMPAL NETWORK DISRUPTION, AND COGNITIVE DEFICITS
P4‐058: A NOVEL TRANSGENIC RAT MODEL THAT PRESENTS PATHOPHYSIOLOGICAL LEVELS OF HUMAN TAU IN CSF, AXONOPATHY, HIPPOCAMPAL NETWORK DISRUPTION, AND COGNITIVE DEFICITS Open
Current widely used tau transgenic mouse models rely on the supra-physiological expression of a single isoform of human tau harboring a mutation that is not associated with AD. Furthermore, the phenotype of these models is often related to…
View article: Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus
Monoclonal antibody targeting BDCA2 ameliorates skin lesions in systemic lupus erythematosus Open
Biogen Inc.
View article: Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease
Defining Changes in the Spatial Distribution and Composition of Brain Lipids in the Shiverer and Cuprizone Mouse Models of Myelin Disease Open
Myelin is composed primarily of lipids and diseases affecting myelin are associated with alterations in its lipid composition. However, correlation of the spatial (in situ) distribution of lipids with the disease-associated compositional a…
View article: PDGF-BB Promotes Type I IFN-Dependent Vascular Alterations and Monocyte Recruitment in a Model of Dermal Fibrosis
PDGF-BB Promotes Type I IFN-Dependent Vascular Alterations and Monocyte Recruitment in a Model of Dermal Fibrosis Open
Systemic sclerosis (SSc) is a chronic autoimmune disorder that can result in extensive tissue damage in the skin and, in advanced cases, internal organs. Vasculopathy, aberrant immune activation, and tissue fibrosis are three hallmarks of …
View article: Small molecule mediated inhibition of <scp>ROR</scp><i>γ</i>‐dependent gene expression and autoimmune disease pathology <i>in vivo</i>
Small molecule mediated inhibition of <span>ROR</span><i>γ</i>‐dependent gene expression and autoimmune disease pathology <i>in vivo</i> Open
Summary Retinoic acid receptor‐related orphan nuclear receptor γ ( ROR γ ) orchestrates a pro‐inflammatory gene expression programme in multiple lymphocyte lineages including T helper type 17 (Th17) cells, γδ T cells, innate lymphoid cells…