Stefan Jungwirth
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View article: Cooperative Clamp-Mediated Promoter Recognition by Poxviral RNAP and Its TBP/TFIIB-Like Partner
Cooperative Clamp-Mediated Promoter Recognition by Poxviral RNAP and Its TBP/TFIIB-Like Partner Open
The recruitment of RNA polymerase (RNAP) to gene promoters is a critical step in gene expression. For RNAP II, this process is initiated by the TATA-box binding protein (TBP) and transcription factor IIB (TFIIB), with homologs of these TBP…
View article: Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1<i>H</i>-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities
Chemistry of polyhalogenated nitrobutadienes, 17: Efficient synthesis of persubstituted chloroquinolinyl-1<i>H</i>-pyrazoles and evaluation of their antimalarial, anti-SARS-CoV-2, antibacterial, and cytotoxic activities Open
A series of 26 novel 1-(7-chloroquinolin-4-yl)-4-nitro-1 H -pyrazoles bearing a dichloromethyl and an amino or thio moiety at C3 and C5 has been prepared in yields up to 72% from the reaction of 1,1-bisazolyl-, 1-azolyl-1-amino-, and 1-thi…
View article: Dual Agents: Fungal Macrocidins and Synthetic Analogues with Herbicidal and Antibiofilm Activities
Dual Agents: Fungal Macrocidins and Synthetic Analogues with Herbicidal and Antibiofilm Activities Open
Eight analogues of the bioherbicides macrocidin A (1) and Z (2) with structural variance in the size of the macrocycle, its para- or meta-cyclophane character, and its functional groups were synthesized on two modular routes and tested for…
View article: Similar Is Not the Same – Mate Recognition in a Parasitoid Wasp
Similar Is Not the Same – Mate Recognition in a Parasitoid Wasp Open
Finding and recognizing a suitable mate is a key prerequisite to reproductive success. Insects often recognize prospective mates using chemical cues and signals. Among these, cuticular lipids commonly serve for mate recognition at close ra…