Stefan Krüger
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View article: Primary Epithelioid Hemangioendothelioma of the Spine: A First in Africa. A Case Report and Literature Review
Primary Epithelioid Hemangioendothelioma of the Spine: A First in Africa. A Case Report and Literature Review Open
Primary Epithelioid hemangioendothelioma of the spine is an ultra‐rare malignant vascular neoplasm with no pathognomonic clinical features and as such requires a high index of suspicion and a multi‐disciplinary and multimodality treatment …
View article: Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials
Mortality in septic patients treated with short-acting betablockers: a comprehensive meta-analysis of randomized controlled trials Open
View article: Predictors of Early Mortality After Traumatic Spinal Cord Injury in South Africa
Predictors of Early Mortality After Traumatic Spinal Cord Injury in South Africa Open
Study Design Retrospective cohort study. Objectives To identify predictors for early mortality following traumatic spinal cord injury (TSCI), as recognition of factors associated with early mortality is essential for public resource alloca…
View article: Dynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in Dictyostelium amoebae
Dynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in Dictyostelium amoebae Open
The centrosome of the amoebozoan model Dictyostelium discoideum provides the best-established model for an acentriolar centrosome outside the Opisthokonta. Dictyostelium exhibits an unusual centrosome cycle, in which duplication is initiat…
View article: Effect of TTF-1 expression on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer
Effect of TTF-1 expression on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer Open
In a real-life setting, we found that TTF-1 expression is associated with an increased PFS. Patients with chemo-/immunotherapy and immunotherapy seem to have a better therapy response in pulmonary adenocarcinoma with TTF-1 expression.
View article: Murine matrix metalloproteinase 13 and human matrix metalloproteinase 1 are involved in remodelling processes after myocardial infarction
Murine matrix metalloproteinase 13 and human matrix metalloproteinase 1 are involved in remodelling processes after myocardial infarction Open
Funding Acknowledgements Type of funding sources: Foundation. Main funding source(s): German Centre for Cardiovascular Research (DZHK) Background Cardiovascular diseases such as myocardial infarction (MI) remain a leading cause of death in…
View article: Primary epithelioid hemangioendothelioma of the Spine: A first in Africa. A case report and literature review
Primary epithelioid hemangioendothelioma of the Spine: A first in Africa. A case report and literature review Open
View article: The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis
The influence of fixation and cryopreservation of cerebrospinal fluid on antigen expression and cell percentages by flow cytometric analysis Open
View article: Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project
Estimates of protection levels against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season: the IMMUNEBRIDGE project Open
Purpose Despite the need to generate valid and reliable estimates of protection levels against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected popula…
View article: Immune correlates against SARS-CoV-2 infection – results of population and hospital-based studies in the IMMUNEBRIDGE project in Germany, 2022
Immune correlates against SARS-CoV-2 infection – results of population and hospital-based studies in the IMMUNEBRIDGE project in Germany, 2022 Open
Einleitung In spring 2022, Germany lacked systematically collected population-based SARS-CoV-2 data allowing real-time assessment of protection levels against severe course of COVID-19. To fill this gap, the IMMUNEBRIDGE project, a joint c…
View article: SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 2022
SARS-CoV-2 sero-immunity and quality of life in children and adolescents in relation to infections and vaccinations: the IMMUNEBRIDGE KIDS cross-sectional study, 2022 Open
View article: Estimates of protection against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season - the IMMUNEBRIDGE project
Estimates of protection against SARS-CoV-2 infection and severe COVID-19 in Germany before the 2022/2023 winter season - the IMMUNEBRIDGE project Open
Despite the need to generate valid and reliable estimates of protection against SARS-CoV-2 infection and severe course of COVID-19 for the German population in summer 2022, there was a lack of systematically collected population-based data…
View article: Effect of antimicrobial therapy on progression-free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer
Effect of antimicrobial therapy on progression-free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer Open
View article: Long-COVID: Impfung und frühe antivirale Therapie senken das Risiko
Long-COVID: Impfung und frühe antivirale Therapie senken das Risiko Open
Long COVID is a complex condition affecting quality of life, with limited therapeutic options. We investigated the occurrence of long COVID in subjects receiving early therapy with monoclonal antibodies (mAbs) or antivirals to reduce the r…
View article: The Influence of Fixation and Cryopreservation of Cerebrospinal Fluid on Antigen Expression and Cell Percentages by Flow Cytometric Analysis
The Influence of Fixation and Cryopreservation of Cerebrospinal Fluid on Antigen Expression and Cell Percentages by Flow Cytometric Analysis Open
The pauci-cellular nature of cerebrospinal (CSF), particularly ventricular CSF, and the rapid cell death following sampling, incumbers the use of flow cytometric analysis of these samples in the investigation of central nervous system (CNS…
View article: Effect of antimicrobial therapy on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer
Effect of antimicrobial therapy on progression free survival of immunotherapy and chemo-/immunotherapy in patients with non-small cell lung cancer Open
Background: The choice between immunotherapy with a checkpoint inhibitor (CPI) and chemo-/immunotherapy (CIT) in patients with NSCLC stage IV is often discussed. There is some data that the effect of CPI-therapy is impaired by antimicrobia…
View article: 2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten
2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten Open
Diese zweite Interimsanalyse stellt eine Datenzusammenführung von Daten verschiedener Studien (GUIDE, NAKO Gesundheitsstudie, MuSPAD, STAAB, paedSAXCOVID, Wü-KITa-CoV, Corkid, IMMUNEBRIDGE_ED) dar, die im Sommer 2022 von Juni bis Anfang Se…
View article: 2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten
2. Interimsanalyse des IMMUNEBRIDGE-Projektes zur Kommunikation von vorläufigen Ergebnissen an das Modellierungsnetz für schwere Infektionskrankheiten Open
Diese zweite Interimsanalyse stellt eine Datenzusammenführung von Daten verschiedener Studien (GUIDE, NAKO Gesundheitsstudie, MuSPAD, STAAB, paedSAXCOVID, Wü-KITa-CoV, Corkid, IMMUNEBRIDGE_ED) dar, die im Sommer 2022 von Juni bis Anfang Se…
View article: Nintedanib plus docetaxel after progression on first-line immunochemotherapy in patients with lung adenocarcinoma: Cohort C of the non-interventional study, VARGADO
Nintedanib plus docetaxel after progression on first-line immunochemotherapy in patients with lung adenocarcinoma: Cohort C of the non-interventional study, VARGADO Open
This analysis indicates that nintedanib plus docetaxel represents an effective second-line treatment option in patients with advanced adenocarcinoma NSCLC following progression on first-line immunochemotherapy. The safety profile was manag…
View article: Real-World Efficacy of Nintedanib Plus Docetaxel After Progression on Immune Checkpoint Inhibitors: Results From the Ongoing, Non-interventional VARGADO Study
Real-World Efficacy of Nintedanib Plus Docetaxel After Progression on Immune Checkpoint Inhibitors: Results From the Ongoing, Non-interventional VARGADO Study Open
Nintedanib plus docetaxel demonstrated a high response rate and disease stabilisation in the third-line setting after failure of prior chemotherapy and ICI treatment, with a manageable safety profile. These results suggest that nintedanib …
View article: Moderate bis schwere SARS-CoV-2-Infektion: Patienten können von niedrig dosierten Kortikosteroiden profitieren
Moderate bis schwere SARS-CoV-2-Infektion: Patienten können von niedrig dosierten Kortikosteroiden profitieren Open
Background: We performed a multicenter, randomized open-label trial in patients with moderate to severe Covid-19 treated with a range of possible treatment regimens. Methods: Patients were randomly assigned to one of three regimen g…
View article: Effect of antimicrobial therapy on progression-free survival of patients with non-small cell lung cancer receiving checkpoint inhibitor- and chemotherapy
Effect of antimicrobial therapy on progression-free survival of patients with non-small cell lung cancer receiving checkpoint inhibitor- and chemotherapy Open
View article: Effect of antimicrobial therapy on progression free survival of patients with non-small-cell lung cancer receiving checkpoint-inhibitor- and chemotherapy
Effect of antimicrobial therapy on progression free survival of patients with non-small-cell lung cancer receiving checkpoint-inhibitor- and chemotherapy Open
BackgroundCheckpoint-inhibitor therapy (CPI) has significantly changed therapy in non-small cell lung cancer (NSCLC) in recent years. There is some data that the effect of CPI-therapy is influenced by the microbiome. Little is known about …
View article: Afatinib as first-line treatment in patients with <i>EGFR</i>-mutated non-small cell lung cancer in routine clinical practice
Afatinib as first-line treatment in patients with <i>EGFR</i>-mutated non-small cell lung cancer in routine clinical practice Open
Background: Lung cancer is a leading cause of cancer-related death in Germany and worldwide. Non-small cell lung cancer (NSCLC) comprises ~80% of lung cancer diagnoses; in White patients, around 10% of NSCLC cases are epidermal growth fact…
View article: What is the Impact of the European Resuscitation Council Covid-19 Guidelines on Resuscitation Quality – A Manakin Study
What is the Impact of the European Resuscitation Council Covid-19 Guidelines on Resuscitation Quality – A Manakin Study Open
Background To evaluate the effects of European Resuscitation Council (ERC) Covid-19-guidelines on resuscitation quality. Methods In an observational manikin study paramedics and emergency physicians performed Advanced-Cardiac-Life-Support …
View article: 1372P Efficacy and safety of nintedanib + docetaxel in lung adenocarcinoma patients (pts) after failure of previous immune checkpoint inhibitor therapy (ICIs): Updated results from the ongoing non-interventional study (NIS) VARGADO (NCT02392455)
1372P Efficacy and safety of nintedanib + docetaxel in lung adenocarcinoma patients (pts) after failure of previous immune checkpoint inhibitor therapy (ICIs): Updated results from the ongoing non-interventional study (NIS) VARGADO (NCT02392455) Open
View article: Infektiöse Lungenerkrankungen erkennen und einschätzen: Herausforderungen zwischen Tuberkulose und Pneumonie
Infektiöse Lungenerkrankungen erkennen und einschätzen: Herausforderungen zwischen Tuberkulose und Pneumonie Open
View article: Publisher's Note
Publisher's Note Open
View article: Veranstaltungskalender
Veranstaltungskalender Open
View article: Veranstaltungskalender
Veranstaltungskalender Open