Ștefan Lujinschi
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View article: #847 Impact of SGLT2 inhibitors on kidney function and proteinuria in patients with membranous nephropathy
#847 Impact of SGLT2 inhibitors on kidney function and proteinuria in patients with membranous nephropathy Open
Background and Aims The current management of membranous nephropathy (MN), based on immunosuppressive therapy and renin-angiotensin-aldosterone system blockade, is insufficient in certain cases to control proteinuria and the progression of…
View article: #854 Real world experience with SGLT2 inhibitors in IgA nephropathy: a case-control study
#854 Real world experience with SGLT2 inhibitors in IgA nephropathy: a case-control study Open
Background and Aims Sodium-glucose cotransporter 2 inhibitors (SGLT2i) determined a significant improvement in proteinuria and a reduction of the risk of chronic kidney disease progression in patients with IgA Nephropathy (IgAN). We sought…
View article: #1046 The impact of remission occurrence on long-term renal survival in IgA nephropathy
#1046 The impact of remission occurrence on long-term renal survival in IgA nephropathy Open
Background and Aims We sought to evaluate the impact of remission occurrence on long-term renal survival in IgA Nephropathy (IgAN). Method We conducted a retrospective study that enrolled 230 patients with biopsy-proven IgAN and at least 6…
View article: #569 Safety and efficacy of Tolvaptan in real-world high-risk patients with ADPKD—a single center experience
#569 Safety and efficacy of Tolvaptan in real-world high-risk patients with ADPKD—a single center experience Open
Background and Aims Autosomal dominant polycystic kidney disease (ADPKD) is the most common monogenic kidney disorder. It is characterized by the formation of bilateral kidney cysts leading to the progressive decline in kidney function. To…
View article: Clinical Predictors of Underlying Histologic Activity in Patients with Lupus Nephritis: A Focus on Urinary Soluble CD163
Clinical Predictors of Underlying Histologic Activity in Patients with Lupus Nephritis: A Focus on Urinary Soluble CD163 Open
Background/Objectives: We sought to evaluate the clinical predictors of underlying histologic activity in patients with lupus nephritis (LN), with a focus on urinary soluble protein CD163 (usCD163). Methods: We conducted a retrospective, c…
View article: Candidate Genetic Modifiers in Alport Syndrome: A Case Series
Candidate Genetic Modifiers in Alport Syndrome: A Case Series Open
Background: Alport syndrome (AS) is one of the most common monogenic kidney disorders. Recent studies have highlighted the modifier effect of variants involving podocyte and non-collagenous extracellular matrix (ECM) proteins in AS. Method…
View article: Genotype–Phenotype Correlations in Alport Syndrome—A Single-Center Experience
Genotype–Phenotype Correlations in Alport Syndrome—A Single-Center Experience Open
Background: Alport syndrome (AS) is a common and heterogeneous genetic kidney disease, that often leads to end-stage kidney disease (ESKD). Methods: This is a single-center, retrospective study that included 36 adults with type IV collagen…
View article: #1393 Urinary soluble CD163 correlates with glomerular inflammation in proliferative lupus nephritis
#1393 Urinary soluble CD163 correlates with glomerular inflammation in proliferative lupus nephritis Open
Background and Aims Clinical distinction between histologic activity and chronicity in lupus nephritis remains challenging. We sought to evaluate the utility of urinary soluble protein CD613 (usCD163) as a potential biomarker to reflect hi…
View article: Histological reappraisal of IgA nephropathy: the role of glomerular pattern of injury and mesangial complement deposition
Histological reappraisal of IgA nephropathy: the role of glomerular pattern of injury and mesangial complement deposition Open
Background There is a clear need to refine the histological assessment in IgA Nephropathy (IgAN). We sought to investigate the clinical significance of the light microscopy (LM) pattern of glomerular injury and of the intensity of mesangia…