Stefan Lyer
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View article: Dual-Modality Ultrasound Imaging of SPIONs Distribution via Combined Magnetomotive and Passive Cavitation Imaging
Dual-Modality Ultrasound Imaging of SPIONs Distribution via Combined Magnetomotive and Passive Cavitation Imaging Open
Superparamagnetic iron oxide nanoparticles (SPIONs) have shown promise across a wide range of biomedical applications, including targeted drug delivery, magnetic hyperthermia, magnetic resonance imaging, and regenerative medicine. In the c…
View article: Combined Magnetomotive and Passive Cavitation Imaging Within Complex Ultrasound Flow Phantom
Combined Magnetomotive and Passive Cavitation Imaging Within Complex Ultrasound Flow Phantom Open
Superparamagnetic iron oxide nanoparticles (SPIONs) have shown promise across a wide range of biomedical applications, including targeted drug delivery, magnetic hyperthermia, magnetic resonance imaging, and regenerative medicine. In the c…
View article: Exploring the Interplay Between Hyperthermia and Cytotoxic Drugs in Ocular Melanoma Cell Lines: Implications and Variability in Treatment Efficiency
Exploring the Interplay Between Hyperthermia and Cytotoxic Drugs in Ocular Melanoma Cell Lines: Implications and Variability in Treatment Efficiency Open
This study serves as preliminary work for the inclusion of superparamagnetic iron oxide nanoparticles functionalized with cytotoxic drugs, which may present a promising therapeutic strategy for treating ocular melanomas. Although further r…
View article: Passive Acoustic Mapping of Cavitation in Heterogeneous Speed of Sound Distributions using the Fast Marching Method
Passive Acoustic Mapping of Cavitation in Heterogeneous Speed of Sound Distributions using the Fast Marching Method Open
Passive Acoustic Mapping (PAM) is a technique used to localize cavitation events in biomedical applications such as targeted drug delivery, histotripsy, and lithotripsy. Accurate cavitation mapping is essential for optimizing therapeutic e…
View article: 3D Magnetomotive Displacement Estimation of Magnetic Nanoparticles using a Matrix Transducer
3D Magnetomotive Displacement Estimation of Magnetic Nanoparticles using a Matrix Transducer Open
Magnetic Drug Targeting (MDT) is a promising technique for local chemotherapy, employing magnetic nanoparticles (MNPs) and an external electromagnet to concentrate chemotherapeutic agents at tumor sites. Achieving complete tumor perfusion …
View article: Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms
Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms Open
Magnetic nanoparticles (MNPs) can be used in various biomedical applications, such as magnetic drug targeting (MDT) or magnetic hyperthermia for cancer treatment. MNPs are injected into the body and accumulated with an external magnetic fi…
View article: Ultrasound-based Eigenfrequency Analysis to Determine Material Parameters of Tissue Mimicking Phantoms
Ultrasound-based Eigenfrequency Analysis to Determine Material Parameters of Tissue Mimicking Phantoms Open
A modern area of research in cancer treatment is magnetic drug targeting (MDT) with superparamagnetic iron oxide nanoparticles (SPIONs). In order to understand the processes involved in MDT in more detail and to be able to perform this the…
View article: Ultrasound-Induced Stable and Inertial Cavitation of Magnetic Nanoparticles for Drug Delivery Applications
Ultrasound-Induced Stable and Inertial Cavitation of Magnetic Nanoparticles for Drug Delivery Applications Open
Drug-loaded magnetic nanoparticles (MNPs) accumulated by an external magnetic field already showed their efficacy in localized tumor treatment in animal studies. Furthermore, specific MNPs are sonosensitive, enabling them to generate inert…
View article: A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications
A Review on Ultrasound-based Methods to Image the Distribution of Magnetic Nanoparticles in Biomedical Applications Open
Magnetic nanoparticles (MNPs) have gained significant attention in biomedical engineering and imaging applications due to their unique magnetic and mechanical properties. With their high magnetization and small size, MNPs serve as excitati…
View article: Mapping wrist motion: <scp>3D CT</scp> analysis after scapholunate ligament transection
Mapping wrist motion: <span>3D CT</span> analysis after scapholunate ligament transection Open
The injury of the scapholunate (SL) ligament is common in wrist traumas leading to pain and reduced wrist function. The wrist's unique joint design and possible underlying theories as the carpal row theory were subject to earlier investiga…
View article: Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features
Accumulation of Iron Oxide-Based Contrast Agents in Rabbit Atherosclerotic Plaques in Relation to Plaque Age and Vulnerability Features Open
Older atherosclerotic plaques with vulnerable features in rabbits are a useful tool for investigating iron oxide-based contrast agents for MRI. Based on the experimental data, SPIONDex particles constitute a promising candidate for further…
View article: An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow
An in silico model of the capturing of magnetic nanoparticles in tumour spheroids in the presence of flow Open
One of the main challenges in improving the efficacy of conventional chemotherapeutic drugs is that they do not reach the cancer cells at sufficiently high doses while at the same time affecting healthy tissue and causing significant side …
View article: Wall-less Flow Phantoms with 3D printed Soluble Filament for Ultrasonic Experiments
Wall-less Flow Phantoms with 3D printed Soluble Filament for Ultrasonic Experiments Open
Tissue-mimicking materials (TMMs) typically used for ultrasound phantoms include gelatin, agarose and polyvinyl alcohol (PVA). These materials have shown sufficient similarity in ultrasound parameters compared to human tissue. Despite thei…
View article: Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system
Simulation and experimental validation of magnetic nanoparticle accumulation in a bloodstream mimicking flow system Open
In this paper, a mathematical model for the dynamics of superparamagnetic iron oxide nanoparticles (SPIONs) in a laminar flow through a pipe under the influence of an external magnetic field of a single electromagnet is derived. The model …
View article: Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs
Magnetic Removal of Candida albicans Using Salivary Peptide-Functionalized SPIONs Open
SPION-APTES-Pep can magnetically remove more than 80% of the microorganism and with a high selective host-pathogen distinction Candida albicans from water-based media and about 55% in blood after 8 minutes processing without compromising e…
View article: Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids
Mitoxantrone and Mitoxantrone-Loaded Iron Oxide Nanoparticles Induce Cell Death in Human Pancreatic Ductal Adenocarcinoma Cell Spheroids Open
Pancreatic ductal adenocarcinoma is a hard-to-treat, deadly malignancy. Traditional treatments, such as surgery, radiation and chemotherapy, unfortunately are still not able to significantly improve long-term survival. Three-dimensional (3…
View article: Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety
Comparative in vitro and in vivo Evaluation of Different Iron Oxide-Based Contrast Agents to Promote Clinical Translation in Compliance with Patient Safety Open
The results indicate that SPIONDex possess an exceptional safety compared to the other two formulations, making them a promising candidate for further clinical translation.
View article: Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy
Determining the resolution of a tracer for magnetic particle imaging by means of magnetic particle spectroscopy Open
We evaluated 9 tracers by magnetic particle spectroscopy to estimate their magnetic particle imaging capability and investigated the correlation of 3 MPS parameters and the hydrodynamic size distribution with the achievable MPI resolution …
View article: Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes
Biocompatibility of Dextran-Coated 30 nm and 80 nm Sized SPIONs towards Monocytes, Dendritic Cells and Lymphocytes Open
Dextran-coated superparamagnetic iron oxide nanoparticles (SPIONDex) of various sizes can be used as contrast agents in magnetic resonance imaging (MRI) of different tissues, e.g., liver or atherosclerotic plaques, after intravenous inject…
View article: In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions
In Vitro Setup for Determination of Nanoparticle-Mediated Magnetic Cell and Drug Accumulation in Tumor Spheroids under Flow Conditions Open
Superparamagnetic iron oxide nanoparticles (SPIONs) are used in nanomedicine as transporter systems for therapeutic cargos, or to magnetize cells to make them magnetically guidable. In cancer treatment, the site-directed delivery of chemot…
View article: Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics
Critical Offset Magnetic PArticle SpectroScopy for rapid and highly sensitive medical point-of-care diagnostics Open
Magnetic nanoparticles (MNPs) have been adapted for many applications, e.g., bioassays for the detection of biomarkers such as antibodies, by controlled engineering of specific surface properties. Specific measurement of such binding state…
View article: Biomimetic Magnetic Particles for the Removal of Gram-Positive Bacteria and Lipoteichoic Acid
Biomimetic Magnetic Particles for the Removal of Gram-Positive Bacteria and Lipoteichoic Acid Open
Gram+ bacteria are very common in clinical medicine and responsible for a large number of infectious diseases. For example, Gram+ bacteria play a major role in causing bloodstream infections and sepsis. Therefore, the detection of Gram+ ba…