Explanipedia

Reversibility in plethysmographic airway and specific airway resistance in children Open

Nicole Beydon, Cécile Du Boisbaudry, Christophe Delclaux, Rola Abou Taam, Iulia Ioan , et al. · 2025

Plethysmographic airway resistance (Raw) and specific airway resistance (sRaw) are widely used to assess baseline lung function and bronchodilator reversibility in children unable to perform spirometry. However, no consensus exists on cut-…

Cardiopulmonary Fitness and Physical Activity Among Children and Adolescents With Inherited Cardiac Disease Open

Luc Souilla, Oscar Werner, Hélèna Huguet, Arthur Gavotto, Marie Vincenti , et al. · 2025

Importance Historical restrictions on children with inherited cardiac arrhythmia or cardiomyopathy have been implemented to mitigate the potential risk of sudden death, but these limitations can be detrimental to overall health and cardiop…

Home noninvasive ventilation in pediatric patients: Does one size fit all? Open

Sonia Khirani, Lucie Griffon, Alessandro Amaddeo, Florent Baudin, P. Biermé , et al. · 2025

A new biofunctionalized and micropatterned PDMS is able to promote stretching induced human myotube maturation Open

Théo Regagnon, Fabrice Raynaud, Gilles Subra, Gilles Carnac, Gérald Hugon , et al. · 2025

We use laser printing on organic–inorganic material and PDMS to study mechanical stress effect on human muscle cells. This model improves cell alignment and provide insights into muscle cell behavior under stress.

Long term noninvasive respiratory support in children with OSA-I and OSA-II: Data of a nation-wide study Open

Chiara Tommesani, Sonia Khirani, Alessandro Amaddeo, Bruno Massenavette, P. Biermé , et al. · 2024

Lung volume recruitment and airway clearance for children at home in France Open

Sonia Khirani, Lucie Griffon, C. Thébault, Guillaume Aubertin, Pierre E. Dupont , et al. · 2024

Early and late effects of volatile sedation with sevoflurane on respiratory mechanics of critically ill COPD patients Open

Boris Jung, Maxime Fosset, Matthieu Amalric, Elias Baedorf-Kassis, Brian O’Gara , et al. · 2024

Long term noninvasive ventilation in children with OSA-I and OSA-II Open

Brigitte Fauroux, Chiara Tommesani, Sonia Khirani, Alessandro Amaddeo, Bruno Massenavette , et al. · 2024

Objective The aim of the study was to describe the characteristics of otherwise healthy children with obstructive sleep apnea (OSA; OSA-I) and children with OSA and obesity (OSA-II) treated with long term continuous positive airway pressur…

Early hybrid cardiac rehabilitation in congenital heart disease: the QUALIREHAB trial Open

Pascal Amédro, Arthur Gavotto, Hélèna Huguet, Luc Souilla, Anne-Cécile Huby , et al. · 2024

Background and Aims Cardiopulmonary fitness in congenital heart disease (CHD) decreases faster than in the general population resulting in impaired health-related quality of life (HRQoL). As the standard of care seems insufficient to encou…

Pediatric long‐term noninvasive respiratory support in children with central nervous system disorders Open

M.C. Carrara, Guillaume Aubertin, Sonia Khirani, Bruno Massenavette, P. Biermé , et al. · 2023

Rationale The use of long‐term noninvasive respiratory support is increasing in children along with an extension of indications, in particular in children with central nervous system (CNS) disorders. Objective The aim of this study was to …

Aberrant mitochondrial dynamics contributes to diaphragmatic weakness induced by mechanical ventilation Open

Haikel Dridi, Marc Yehya, Robert Barsotti, Yang Liu, Steve Reiken , et al. · 2023

In critical care patients, the “”temporary inactivity of the diaphragm caused by mechanical ventilation (MV) triggers a series of events leading to diaphragmatic dysfunction and atrophy, commonly known as ventilator-induced diaphragm dysfu…

Aerobic physical capacity and health-related quality of life in children with sickle cell disease Open

Corentin Laurent-Lacroix, Marie Vincenti, Stéfan Matecki, Perrine Mahé, Lionel Moulis , et al. · 2023

Purpose To evaluate the aerobic capacity by cardiopulmonary exercise test (CPET) in children and adolescents with sickle cell disease in comparison with healthy matched controls and to determine the factors associated with impaired maximum…

Reference Values of Cardiopulmonary Exercise Test Parameters in the Contemporary Paediatric Population Open

Pascal Amédro, Stéfan Matecki, Taissa Pereira dos Santos, Sophie Guillaumont, Jonathan Rhodes , et al. · 2023

Background The evaluation of health status by cardiopulmonary exercise test (CPET) has shown increasing interest in the paediatric population. Our group recently established reference Z-score values for paediatric cycle ergometer VO 2max ,…

Reference values of cardiopulmonary exercise test parameters in the contemporary paediatric population Open

Pascal Amédro, Stéfan Matecki, Taissa Pereira dos Santos, Sophie Guillaumont, Jonathan Rhodes , et al. · 2023

Background: The evaluation of health status by cardiopulmonary exercise test (CPET) has shown increasing interest in the paediatric population. Our group recently established reference Z-score values for paediatric cycloergometer VO_2m…

Use of new paediatric VO2max reference equations to evaluate aerobic fitness in overweight or obese children with congenital heart disease Open

Pascal Amédro, Thibault Mura, Stéfan Matecki, Sophie Guillaumont, Anne Requirand , et al. · 2023

Aims Overweight and obesity in children with congenital heart disease (CHD) represent an alarming cardiovascular risk. Promotion of physical activity and cardiac rehabilitation in this population requires assessing the level of aerobic fit…

Correlation between three-dimensional echocardiography and cardiopulmonary fitness in patients with univentricular heart: A cross-sectional multicentre prospective study Open

Valentin Femenia, Victor Pommier, Hélèna Huguet, Xavier Iriart, Marie‐Christine Picot , et al. · 2023

Reference values of aerobic fitness in the contemporary paediatric population Open

Arthur Gavotto, Thibault Mura, Jonathan Rhodes, Suellen Yin, Alfred Hager , et al. · 2023

Aims There has been a growing interest in the use of markers of aerobic physical fitness (VO2max assessed by cardiopulmonary exercise test (CPET)) in the follow-up of paediatric chronic diseases. The dissemination of CPET in paediatrics re…

Impaired aerobic capacity in adolescents and young adults after treatment for cancer or non-malignant haematological disease Open

Arthur Gavotto, Vincent Dubard, Martina Avesani, Hélèna Huguet, Marie‐Christine Picot , et al. · 2023

Cardiorespiratory fitness, muscle fitness, and physical activity in children with long QT syndrome: A prospective controlled study Open

Luc Souilla, Martina Avesani, Aymeric Boisson, Anne Requirand, Stéfan Matecki , et al. · 2023

Background In children with congenital long QT syndrome (LQTS), the risk of arrhythmic events during exercise commonly makes it difficult to balance exercise restrictions versus promotion of physical activity. Nevertheless, in children wit…

Cardiopulmonary fitness in children with asthma versus healthy children Open

Johan Moreau, Floriane Socchi, M Renoux, Anne Requirand, Hamouda Abassi , et al. · 2022

Objectives To evaluate, with a cardiopulmonary exercise test (CPET), the cardiopulmonary fitness of children with asthma, in comparison to healthy controls, and to identify the clinical and CPET parameters associated with the maximum oxyge…

Aerobic fitness change with time in children with congenital heart disease: A retrospective controlled cohort study Open

Arthur Gavotto, Manon Ladeveze, Martina Avesani, Hélèna Huguet, Sophie Guillaumont , et al. · 2022

Double gas transfer factors (DLCO-DLNO) at rest in patients with congenital heart diseases correlates with their ventilatory response during maximal exercise Open

Grégoire De La Villeon, Arthur Gavotto, Nam Le-Dong, Charlène Bredy, Sophie Guillaumont , et al. · 2022

CHD patients with impaired pulmonary circulation have a reduced Dm and Vcap mainly due to decreased pulmonary volume but maintain a normal capacity to adapt these parameters through a simple recruitment manoeuver. Vcap adaptation evaluated…

Skeletal Ryanodine Receptors Are Involved in Impaired Myogenic Differentiation in Duchenne Muscular Dystrophy Patients Open

Pierre Meyer, Cécile Notarnicola, Albano C. Méli, Stéfan Matecki, Gérald Hugon , et al. · 2021

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting following repeated muscle damage and inadequate regeneration. Impaired myogenesis and differentiation play a major role in DMD as well as intracellular calciu…

Physical activity and aerobic fitness in children with inherited cardiac diseases Open

Aymeric Boisson, Grégoire De La Villeon, Hélèna Huguet, Hamouda Abassi, Jean-Luc Pasquié , et al. · 2021

Health-related quality of life and physical activity in children with inherited cardiac arrhythmia or inherited cardiomyopathy: the prospective multicentre controlled QUALIMYORYTHM study rationale, design and methods Open

Pascal Amédro, Oscar Werner, Hamouda Abassi, Aymeric Boisson, Luc Souilla , et al. · 2021

Shear Wave Elastography, a New Tool for Diaphragmatic Qualitative Assessment: A Translational Study Open

Yassir Aarab, Aurelien Flatres, Fanny Garnier, Mathieu Capdevila, Fabrice Raynaud , et al. · 2021

Rationale: Prolonged mechanical ventilation is often associated with either a decrease (known atrophy) or an increase (supposed injury) in diaphragmatic thickness. Shear wave elastography is a noninvasive technique that measures she…

Health-Related Quality of Life and Physical Activity in Children with Inherited Cardiac Arrhythmia or Inherited Cardiomyopathies: The Prospective Multicentre Controlled QUALIMYORYTHM Study Rationale, Design and Methods. Open

Pascal Amédro, Oscar Werner, Hamouda Abassi, Aymeric Boisson, Luc Souilla , et al. · 2021

Background : Advances in paediatric cardiology has improved the prognosis of children with inherited cardiac disorders. However, health-related quality of life (QoL) and physical activity have been scarcely analysed in children with inheri…

Paediatric long term continuous positive airway pressure and noninvasive ventilation in France: A cross-sectional study Open

Brigitte Fauroux, Sonia Khirani, Alessandro Amaddeo, Bruno Massenavette, P. Biermé , et al. · 2021

Late Ventilator-Induced Diaphragmatic Dysfunction After Extubation Open

Haikel Dridi, Boris Jung, Mohamad Yehya, Aurélien Daurat, Steven Reiken , et al. · 2020

Objectives: Mechanical ventilation is associated with primary diaphragmatic dysfunction, also termed ventilator-induced diaphragmatic dysfunction. Studies evaluating diaphragmatic function recovery after extubation are lacking. We evaluate…

The Ve/Vco2 slope: a useful tool to evaluate the physiological status of children with congenital heart disease Open

Arthur Gavotto, Hélèna Huguet, Marie‐Christine Picot, Sophie Guillaumont, Stéfan Matecki , et al. · 2020

Using V̇e/V̇co 2 slope is useful for children with congenital heart disease. V̇e/V̇co 2 slope is sensitive to pulmonary blood flow maldistribution during exercise, this concerns congenital heart disease with pulmonary regurgitation, tricuspid …

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