Stefan Nierkens
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View article: T-cell responses to SARS-CoV-2 vaccinations in adults with Down syndrome – a prospective cohort study
T-cell responses to SARS-CoV-2 vaccinations in adults with Down syndrome – a prospective cohort study Open
Down syndrome (DS) is associated with immune dysfunction, which led to higher hospitalization and mortality rates during the COVID-19 pandemic. We previously showed that antibody concentrations were lower in adults with DS after primary SA…
View article: Risk Factors for Alloimmune Lung Syndromes after Allogeneic Hematopoietic Cell Transplantation in Children
Risk Factors for Alloimmune Lung Syndromes after Allogeneic Hematopoietic Cell Transplantation in Children Open
The non-infectious pulmonary complications idiopathic pneumonia syndrome (IPS) and bronchiolitis obliterans syndrome (BOS) are important causes of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT). To i…
View article: New biomarkers for the diagnosis of primary Central nervous system lymphoma in CSF: a multicenter retrospective cohort study
New biomarkers for the diagnosis of primary Central nervous system lymphoma in CSF: a multicenter retrospective cohort study Open
Background Primary central nervous system lymphoma (PCNSL) is a rare form of non-Hodgkin lymphoma. Diagnosis usually requires a brain biopsy, which is associated with complications and delay of diagnosis. Cerebrospinal fluid (CSF) analysis…
View article: Harmonized Immune Recovery Monitoring after HCT: Evidence & Practical Guidance from the Westhafen Intercontinental Group
Harmonized Immune Recovery Monitoring after HCT: Evidence & Practical Guidance from the Westhafen Intercontinental Group Open
Allogeneic hematopoietic cell transplantation (allo-HCT) is a curative option for patients with high-risk malignancies and non-malignant disorders. Long-term survival depends on robust immune reconstitution (IR), which governs overall immu…
View article: Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia
Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia Open
View article: Hole in one: CD137-ADC eliminates GVHD
Hole in one: CD137-ADC eliminates GVHD Open
View article: Multilineage involvement in ABL-class fusion–positive pediatric B-cell acute lymphoblastic leukemia: CML-like biology
Multilineage involvement in ABL-class fusion–positive pediatric B-cell acute lymphoblastic leukemia: CML-like biology Open
Not available.
View article: Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation Open
Clinical responses with chimeric antigen receptor (CAR) T cells are encouraging, but primary resistance and relapse after therapy prevent durable remission in many patients with cancer, with apoptosis resistance in cancer cells that limits…
View article: Applications of cryotherapy in premalignant and malignant esophageal disease: Preventing, treating, palliating disease and enhancing immunogenicity?
Applications of cryotherapy in premalignant and malignant esophageal disease: Preventing, treating, palliating disease and enhancing immunogenicity? Open
Cryotherapy is a treatment modality that uses extreme cold to destroy unwanted tissue through both immediate and delayed cellular injury. This therapy is increasingly being adopted across various medical specialties due to its minimally in…
View article: Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia
Bone marrow lymphocyte dynamics during chemotherapy in pediatric acute myeloid leukemia Open
SUMMARY A better understanding of lymphocyte dynamics during current treatment regimens in pediatric AML is urgently needed to understand whether the application of bispecific T-cell-engagers (BiTEs) during periods of low tumor burden coul…
View article: Minimal residual disease assessment following CD19‐targeted therapy in B‐cell precursor acute lymphoblastic leukemia using standardized 12‐color flow cytometry: A EuroFlow study
Minimal residual disease assessment following CD19‐targeted therapy in B‐cell precursor acute lymphoblastic leukemia using standardized 12‐color flow cytometry: A EuroFlow study Open
Detection of minimal/measurable residual disease (MRD) is a critical prognostic marker in B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL). The EuroFlow Consortium previously developed an 8‐color flow cytometric MRD protocol, effect…
View article: Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as promising CAR T cell target for pediatric solid tumors
Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as promising CAR T cell target for pediatric solid tumors Open
Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant rhabdoid tumor…
View article: Thymic peptides in immune reconstitution and clinical outcome after allogeneic hematopoietic cell transplantation
Thymic peptides in immune reconstitution and clinical outcome after allogeneic hematopoietic cell transplantation Open
View article: Data from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Data from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
In pediatric hematopoietic cell transplantation (HCT) recipients, transplanted donor cells may need to function far beyond normal human lifespan. In this study, we investigated the risk of clonal hematopoiesis (CH) in 144 pediatric long-te…
View article: Supplementary Table S2 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Supplementary Table S2 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Sequencing data
View article: Supplementary Table S4 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Supplementary Table S4 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Clonal hematopoiesis gene panel
View article: Figure S1 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Figure S1 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Overview of screening and inclusion
View article: Supplementary Table S1 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Supplementary Table S1 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Cohort information
View article: Figure S4 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Figure S4 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Additional visualizations of CRP measurements
View article: Supplementary Table S3 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Supplementary Table S3 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Characteristics of total and matched cohorts
View article: Figure S2 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Figure S2 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Additional details on CH mutations in HCT recipients and controls
View article: Figure S3 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Figure S3 from Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
Effect of HCT and different related timespans on CH prevalence
View article: Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors
Cell surface proteomics of patient-derived malignant rhabdoid tumor organoids identifies ROBO1 as potential CAR T cell target for pediatric solid tumors Open
Malignant rhabdoid tumors are highly aggressive pediatric malignancies with limited treatment options and poor outcomes. To expand therapeutic options, we employed mass spectrometry-based cell surface proteomics on malignant rhabdoid tumor…
View article: Improved survival with model-based dosing of antithymocyte globulin in pediatric hematopoietic cell transplantation
Improved survival with model-based dosing of antithymocyte globulin in pediatric hematopoietic cell transplantation Open
Antithymocyte globulin (ATG) is used in pediatric allogeneic hematopoietic cell transplantation (HCT) to prevent graft-versus-host disease (GVHD) and graft failure (GF). Poor T-cell recovery, associated with increased mortality, is the mai…
View article: Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopenia
Ex vivo T-lymphopoiesis assays assisting corrective treatment choice for genetically undefined T-lymphocytopenia Open
Persistent selective T-lymphocytopenia is found both in SCID and congenital athymia. Without molecular diagnosis, it is challenging to determine whether HCT or thymus transplantation ought to be performed. Ex vivo T-lymphopoiesis assays ha…
View article: Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria
Multicenter validation of secondary hemophagocytic lymphohistiocytosis diagnostic criteria Open
Background: Five fulfilled hemophagocytic lymphohistiocytosis (HLH)‐2004 criteria, and the HScore are widely used and recommended by international expert consensus to diagnose secondary HLH. Both diagnostic scores have never been validated…
View article: Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation
Increased Clonal Hematopoiesis in Long-term Survivors of Pediatric Hematopoietic Cell Transplantation Open
In pediatric hematopoietic cell transplantation (HCT) recipients, transplanted donor cells may need to function far beyond normal human lifespan. In this study, we investigated the risk of clonal hematopoiesis (CH) in 144 pediatric long-te…
View article: The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies
The BAMBOO method for correcting batch effects in high throughput proximity extension assays for proteomic studies Open
The proximity extension assay (PEA) enables large-scale proteomic investigations across numerous proteins and samples. However, discrepancies between measurements, known as batch-effects, potentially skew downstream statistical analyses an…
View article: Profiling the immune tumor microenvironment of pediatric brain tumors with cavitron ultrasonic surgical aspirator (CUSA)-derived tissue fragments
Profiling the immune tumor microenvironment of pediatric brain tumors with cavitron ultrasonic surgical aspirator (CUSA)-derived tissue fragments Open
Background Current treatment options for pediatric high-grade brain tumors are limited, with poor 5-year overall survival rates. While immunotherapy is promising for these patients, the composition of their tumor immune microenvironment (T…
View article: Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events
Blood and tissue correlates of steroid non-response in checkpoint inhibition-induced immune-related adverse events Open
High-dose steroids constitute the cornerstone of first-line treatment for immune-related adverse events (irAEs) associated with immune checkpoint inhibitors, but compromise antitumor immunity. A deeper understanding of irAEs and their resp…