Stefan Reuter
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View article: An unexpected focus of infection after kidney transplantation
An unexpected focus of infection after kidney transplantation Open
View article: Evaluating the implementation of the community mental health program GBV: service users’ perspectives
Evaluating the implementation of the community mental health program GBV: service users’ perspectives Open
Introduction A multi-site randomized controlled study demonstrated that the community mental health intervention GBV, when combined with standard care in the German healthcare system, led to greater improvements in empowerment, quality of …
View article: Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis
Exploration of pulse wave analysis under reactive hyperemia and close to an arteriovenous fistula: a comparative analysis Open
View article: Myocardial Perfusion Scintigraphy Provides Incremental Prognostic Value in Patients on the Kidney Transplant Waiting List
Myocardial Perfusion Scintigraphy Provides Incremental Prognostic Value in Patients on the Kidney Transplant Waiting List Open
The approach to cardiovascular risk assessment before renal transplantation is still controversial. Therefore, we evaluated and compared the prognostic value of myocardial perfusion scintigraphy (MPS) and dobutamine stress echocardiography…
View article: A Comprehensive Review of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome
A Comprehensive Review of Tubulointerstitial Nephritis and Uveitis (TINU) Syndrome Open
Background: Tubulointerstitial nephritis and uveitis (TINU) syndrome is a rare autoimmune disorder, characterized by acute tubulointerstitial nephritis and uveitis. It poses diagnostic challenges due to the mostly asynchronous onset of ren…
View article: Tacrolimus—why pharmacokinetics matter in the clinic
Tacrolimus—why pharmacokinetics matter in the clinic Open
The calcineurin inhibitor (CNI) Tacrolimus (Tac) is the most prescribed immunosuppressant drug after solid organ transplantation. After renal transplantation (RTx) approximately 95% of recipients are discharged with a Tac-based immunosuppr…
View article: Urinary dickkopf 3 in a kidney transplant and living donor cohort – independent risk factor or merely GFR-related?
Urinary dickkopf 3 in a kidney transplant and living donor cohort – independent risk factor or merely GFR-related? Open
Urinary Dickkopf 3 (uDKK3) is a marker released by kidney tubular epithelial cells that is associated with the progression of chronic kidney disease (CKD) and may cause interstitial fibrosis and tubular atrophy. Recent evidence suggests th…
View article: Early oral switch in low-risk <i>Staphylococcus aureus</i> bloodstream infection
Early oral switch in low-risk <i>Staphylococcus aureus</i> bloodstream infection Open
Background Staphylococcus aureus bloodstream infection (SAB) is treated with at least 14 days of intravenously administered antimicrobials. We assessed the efficacy and safety of an early oral switch therapy in patients at low risk for SAB…
View article: Corrigendum: Novel Therapeutic Strategies for Dyslipidemia: First Report of Inclisiran Therapy in a Kidney Transplanted Patient
Corrigendum: Novel Therapeutic Strategies for Dyslipidemia: First Report of Inclisiran Therapy in a Kidney Transplanted Patient Open
[This corrects the article DOI: 10.3389/ti.2023.11104.].
View article: Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models
Tolerance Induction in Vascularized Composite Allotransplantation—A Brief Review of Preclinical Models Open
Pre-clinical studies are an obligatory tool to develop and translate novel therapeutic strategies into clinical practice. Acute and chronic rejection mediated by the recipient’s immune system remains an important limiting factor for the (l…
View article: Novel Therapeutic Strategies for Dyslipidemia: First Report of Inclisiran Therapy in a Kidney Transplanted Patient
Novel Therapeutic Strategies for Dyslipidemia: First Report of Inclisiran Therapy in a Kidney Transplanted Patient Open
LETTER TO THE EDITOR Transpl Int, 26 January 2023 https://doi.org/10.3389/ti.2023.11104
View article: First Report on Successful Conversion of Long-Term Treatment of Recurrent Atypical Hemolytic Uremic Syndrome With Eculizumab to Ravulizumab in a Renal Transplant Patient
First Report on Successful Conversion of Long-Term Treatment of Recurrent Atypical Hemolytic Uremic Syndrome With Eculizumab to Ravulizumab in a Renal Transplant Patient Open
LETTER TO THE EDITOR Transpl Int, 03 October 2022 https://doi.org/10.3389/ti.2022.10846
View article: Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation?
Dynamic Parameters of Hypothermic Machine Perfusion—An Image of Initial Graft Function in Adult Kidney Transplantation? Open
Kidney allografts are subjected to ischemia reperfusion injury during the process of transplantation. Hypothermic machine perfusion (HMP) of deceased donor kidneys from organ procurement until transplantation is associated with a superior …
View article: Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury
Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury Open
Ischemia-reperfusion injury is a major cause of acute kidney injury. Many cytokines are involved in the pathogenesis of renal ischemia-reperfusion injury. IL24 is a member of the IL10 family and has gained importance because of its apoptos…
View article: Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation
Hyperspectral Imaging for Assessment of Initial Graft Function in Human Kidney Transplantation Open
The aim of our study was to evaluate hyperspectral imaging (HSI) as a rapid, non-ionizing technique for the assessment of organ quality and the prediction of delayed graft function (DGF) in kidney transplantation after static cold storage …
View article: Belatacept as a Treatment Option in Patients with Severe BK Polyomavirus Infection and High Immunological Risk—Walking a Tightrope between Viral Control and Prevention of Rejection
Belatacept as a Treatment Option in Patients with Severe BK Polyomavirus Infection and High Immunological Risk—Walking a Tightrope between Viral Control and Prevention of Rejection Open
Balancing the immune system with immunosuppressive treatment is essential in kidney transplant recipients to avoid allograft rejection on the one hand and infectious complications on the other. BK polyomavirus nephropathy (BKPyVAN) is a vi…
View article: Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation
Bryostatin-1 Attenuates Ischemia-Elicited Neutrophil Transmigration and Ameliorates Graft Injury after Kidney Transplantation Open
Ischemia reperfusion injury (IRI) is a form of sterile inflammation whose severity determines short- and long-term graft fates in kidney transplantation. Neutrophils are now recognized as a key cell type mediating early graft injury, which…
View article: Improved Kidney Allograft Function after Early Conversion of Fast IR-Tac Metabolizers to LCP-Tac
Improved Kidney Allograft Function after Early Conversion of Fast IR-Tac Metabolizers to LCP-Tac Open
Fast tacrolimus (Tac) metabolism is associated with a more rapid decline of renal function after renal transplantation (RTx). Because the pharmacokinetics of LCP-Tac (LCPT) and immediate-release Tac (IR-Tac) differ, we hypothesized that sw…
View article: iPTH is not a significant factor influencing the tacrolimus C/D ratio
iPTH is not a significant factor influencing the tacrolimus C/D ratio Open
We appreciate our colleagues’ findings on the interesting association between CYP3A5 polymorphism, serum intact-PTH (iPTH) levels, and tacrolimus (TAC) trough.1 CYP3A4 and CYPA5 are important determinants of TAC metabolism, which can be de…
View article: The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial
The Influence of Parathyroidectomy on Osteoporotic Fractures in Kidney Transplant Recipients: Results from a Retrospective Single-Center Trial Open
Kidney transplant (KTx) recipients are a high-risk population for osteoporotic fractures. We herein aim to identify the role of pre-transplant parathyroidectomy (PTX) and other modifiable factors associated with osteoporotic fractures in K…
View article: Determination of unacceptable <scp>HLA</scp> antigen mismatches in kidney transplant recipients
Determination of unacceptable <span>HLA</span> antigen mismatches in kidney transplant recipients Open
With the introduction of the virtual allocation crossmatch in the Eurotransplant (ET) region in 2023, the determination of unacceptable antigen mismatches (UAM) in kidney transplant recipients is of utmost importance for histocompatibility…
View article: C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance
C4d Deposition after Allogeneic Renal Transplantation in Rats Is Involved in Initial Apoptotic Cell Clearance Open
In the context of transplantation, complement activation is associated with poor prognosis and outcome. While complement activation in antibody-mediated rejection is well-known, less is known about complement activation in acute T cell-med…
View article: Increased renal function decline in fast metabolizers using extended-release tacrolimus after kidney transplantation
Increased renal function decline in fast metabolizers using extended-release tacrolimus after kidney transplantation Open
View article: The Tacrolimus Metabolism Rate and Dyslipidemia after Kidney Transplantation
The Tacrolimus Metabolism Rate and Dyslipidemia after Kidney Transplantation Open
Fast tacrolimus (Tac) metabolism is associated with reduced survival rates after renal transplantation (RTx), mainly due to cardiovascular events. Because dyslipidemia is a leading cause of cardiovascular death, we hypothesized that most R…
View article: Parathyroidectomy Protects Against Pathologic Fractures After Kidney Transplantation: Results From a Retrospective Single-center Trial
Parathyroidectomy Protects Against Pathologic Fractures After Kidney Transplantation: Results From a Retrospective Single-center Trial Open
Kidney transplant (KTx) recipients are a high-risk population for pathologic fractures. We herein aim to identify modifiable factors associated with pathological fractures and bone disease in KTx recipients. We conducted a retrospective st…
View article: Tumor Recurrence and Graft Survival in Renal Transplant Recipients with a History of Pretransplant Malignancy: A Matched Pair Analysis
Tumor Recurrence and Graft Survival in Renal Transplant Recipients with a History of Pretransplant Malignancy: A Matched Pair Analysis Open
Organ scarcity demands critical decision-making regarding eligible transplant candidates and graft allocation to ensure best benefit from renal transplantation (RTx). Among the controversial relative contraindications is a history of pretr…
View article: Case Report: Management of a Multidrug-Resistant CMV-Strain in a Renal Transplant Recipient by High-Dose CMV-Specific Immunoglobulins, Modulation in Immunosuppression, and Induction of CMV-Specific Cellular Immunity
Case Report: Management of a Multidrug-Resistant CMV-Strain in a Renal Transplant Recipient by High-Dose CMV-Specific Immunoglobulins, Modulation in Immunosuppression, and Induction of CMV-Specific Cellular Immunity Open
The management of multidrug-resistant strains of cytomegalovirus after solid organ transplantation is challenging. This case report demonstrates the successful treatment of a multidrug-resistant strain of cytomegalovirus that may represent…
View article: Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation
Clinical features of BK-polyomavirus and cytomegalovirus co-infection after kidney transplantation Open
View article: Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) is a Risk Indicator for eGFR Loss in Kidney Transplant Recipients
Soluble Urokinase-Type Plasminogen Activator Receptor (suPAR) is a Risk Indicator for eGFR Loss in Kidney Transplant Recipients Open
Background suPAR is a signaling protein of the Ly6/alpha-neurotoxin family. In the kidney, suPAR contributes to podocyte foot process effacement and glomerular barrier function disruption via activating αvβ3 integrin on the podocyte membra…
View article: Antihypertensive Treatment in Kidney Transplant Recipients—A Current Single Center Experience
Antihypertensive Treatment in Kidney Transplant Recipients—A Current Single Center Experience Open
Arterial hypertension affects the survival of the kidney graft and the cardiovascular morbidity and mortality of the recipient after kidney transplantation (KTx). Thus, antihypertensive treatment is necessary for a vast majority of these p…