Stefan Röder
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View article: Prenatal Exposure to Emerging Pesticides and Childhood Allergy Risk: A Mixture Assessment in an Urban Birth Cohort
Prenatal Exposure to Emerging Pesticides and Childhood Allergy Risk: A Mixture Assessment in an Urban Birth Cohort Open
View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical deconvoluti…
View article: Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood
Prenatal Smoking Exposures and Epigenome-wide Methylation in Newborn Blood Open
Maternal sustained smoking has the largest impact on newborn DNA methylation, suggesting a strong influence of the intrauterine environment. We observed minimal impacts for less studied exposures including SHS, maternal former smoking and …
View article: Maternal asthma and newborn DNA methylation
Maternal asthma and newborn DNA methylation Open
Background Prenatal exposure to maternal asthma may influence DNA methylation patterns in offspring, potentially affecting their susceptibility to later diseases including asthma. Objective To investigate the relationship between parental …
View article: Cell type-specific methylome-wide association studies of childhood ADHD symptoms
Cell type-specific methylome-wide association studies of childhood ADHD symptoms Open
Objective Studying DNA methylation (DNAm) can provide insights into gene-regulatory mechanisms underlying attention-deficit/hyperactivity disorder (ADHD). While most DNAm studies were performed in bulk tissue, this study used statistical d…
View article: Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Epigenetic timing effects on child developmental outcomes: a longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open
Background DNA methylation (DNAm) is a developmentally dynamic epigenetic process; yet, most epigenome-wide association studies (EWAS) have examined DNAm at only one timepoint or without systematic comparisons between timepoints. Thus, it …
View article: Prenatal Exposure To Mixtures of Phthalates and Bisphenol A And Eczema Risk: Findings in Atopic and Non-Atopic Children from the Lina Birth Cohort
Prenatal Exposure To Mixtures of Phthalates and Bisphenol A And Eczema Risk: Findings in Atopic and Non-Atopic Children from the Lina Birth Cohort Open
View article: Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium
Cesarean delivery and blood DNA methylation at birth and childhood: Meta-analysis in the Pregnancy and Childhood Epigenetics Consortium Open
Children born via cesarean delivery have a higher risk of metabolic, immunological, and neurodevelopmental disorders compared to those born via vaginal delivery, although mechanisms remain unclear. We conducted a meta-analysis of epigenome…
View article: Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns
Pesticide residues and polyphenols in urine – A combined LC-HRMS screening to reveal intake patterns Open
Human exposure to pesticides in the general population occurs mainly through food consumption. However, specific dietary habits or food products that contribute to pesticide exposure are often unknown. In this study, we propose a combined …
View article: Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Open
Background: Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to unde…
View article: Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium
Epigenetic timing effects on child developmental outcomes: A longitudinal meta-regression of findings from the Pregnancy And Childhood Epigenetics Consortium Open
DNA methylation (DNAm) is a developmentally dynamic epigenetic process, yet we still know little about how epigenetic effects on health outcomes vary over time; whether DNAm alterations during certain periods of development are more inform…
View article: A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation
A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation Open
View article: Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence Open
View article: Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Background Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms und…
View article: Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation
Epigenome-wide meta-analysis of prenatal maternal stressful life events and newborn DNA methylation Open
View article: Global hypomethylation in childhood asthma identified by genome‐wide DNA‐methylation sequencing preferentially affects enhancer regions
Global hypomethylation in childhood asthma identified by genome‐wide DNA‐methylation sequencing preferentially affects enhancer regions Open
Background Childhood asthma is a result of a complex interaction of genetic and environmental components causing epigenetic and immune dysregulation, airway inflammation and impaired lung function. Although different microarray based EWAS …
View article: Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 1 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 1. Table S1: “Summary of the studies in the meta-analysis for the association between Season of Birth and DNA methylation at birth and in children (age: 1 to 11 years)”. Baseline summary of participants from each of the ind…
View article: Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 5 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 5. Table S4: “Direction of differential methylation of CpGs in DMRs of the at-birth and childhood analyses (preliminary analysis”).
View article: Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 6 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 6. Table S5: “Genes mapped to DMP/DMR identified in at-birth samples of babies born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associatio…
View article: Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Additional file 8 of Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude Open
Additional file 8. Table S8: “Genes mapped to DMR identified in the childhood samples of children born in the latitude ≥ 50°N and some examples of their associations with biological functions”. Provides examples of known functional associa…
View article: IL17F Expression as an Early Sign of Oxidative Stress-Induced Cytotoxicity/Apoptosis
IL17F Expression as an Early Sign of Oxidative Stress-Induced Cytotoxicity/Apoptosis Open
Interleukin 17F (IL17F) has been found to be involved in various inflammatory pathologies and has recently become a target for therapeutic purposes. In contrast to IL17F secreted by immune cells, the focus of this study is to describe the …
View article: Epigenome-Wide Meta-Analysis of Prenatal Maternal Stressful Life Events and Newborn DNA Methylation
Epigenome-Wide Meta-Analysis of Prenatal Maternal Stressful Life Events and Newborn DNA Methylation Open
Prenatal maternal stressful life events are associated with adverse neurodevelopmental outcomes in offspring. Biologic mechanisms underlying these associations are largely unknown, but DNA methylation likely plays a role. This meta-analysi…
View article: EpiVisR: exploratory data analysis and visualization in epigenome-wide association analyses
EpiVisR: exploratory data analysis and visualization in epigenome-wide association analyses Open
Background With the widespread availability of microarray technology for epigenetic research, methods for calling differentially methylated probes or differentially methylated regions have become effective tools to analyze this type of dat…
View article: Longitudinal associations of DNA methylation and sleep in children: a meta-analysis
Longitudinal associations of DNA methylation and sleep in children: a meta-analysis Open
View article: Maternal stress, child behavior and the promotive role of older siblings
Maternal stress, child behavior and the promotive role of older siblings Open
View article: Pro-inflammatory Diet Pictured in Children With Atopic Dermatitis or Food Allergy: Nutritional Data of the LiNA Cohort
Pro-inflammatory Diet Pictured in Children With Atopic Dermatitis or Food Allergy: Nutritional Data of the LiNA Cohort Open
Graphical Abstract Aim and design of the analysed project within the prospective LiNA cohort.
View article: Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis
Neonatal DNA methylation and childhood low prosocial behavior: An epigenome‐wide association meta‐analysis Open
Low prosocial behavior in childhood has been consistently linked to later psychopathology, with evidence supporting the influence of both genetic and environmental factors on its development. Although neonatal DNA methylation (DNAm) has be…
View article: Prenatal paraben exposure and atopic dermatitis‐related outcomes among children
Prenatal paraben exposure and atopic dermatitis‐related outcomes among children Open
Background Parabens, widely used as preservatives in cosmetics, foods, and other consumer products, are suspected of contributing to allergy susceptibility. The detection of parabens in the placenta or amniotic fluid raised concerns about …
View article: Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study
Wood emissions and asthma development: Results from an experimental mouse model and a prospective cohort study Open
View article: Maternal paraben exposure triggers childhood overweight development
Maternal paraben exposure triggers childhood overweight development Open