Explanipedia

Optimized production, purification, and radiolabeling of the 203Pb/212Pb theranostic pair for nuclear medicine Open

Brooke L. McNeil, Simona A. Mastroianni, Scott McNeil, Stefan Zeisler, Joel Kumlin , et al. · 2023

Determination of Distribution Coefficients of Mercury and Gold on Selected Extraction Chromatographic Resins – Towards an Improved Separation Method of Mercury-197 from Proton-Irradiated Gold Targets Open

Shaohuang Chen, Marine Bas, Steffen Happel, Parmissa Randhawa, Scott McNeil , et al. · 2022

Synthesis of DOTA-pyridine chelates for 64Cu coordination and radiolabeling of αMSH peptide Open

Hua Yang, Feng Gao, Brooke L. McNeil, Chengcheng Zhang, Zheliang Yuan , et al. · 2021

Multi-curie production of gallium-68 on a biomedical cyclotron and automated radiolabelling of PSMA-11 and DOTATATE Open

Helge Thisgaard, Joel Kumlin, Niels Langkjær, Jansen Chua, B. Hook , et al. · 2021

Synthesis of DOTA-Pyridine Chelates for 64Cu Coordination and Radiolabeling of αMSH Peptide Open

Hua Yang, Feng Gao, Brooke L. McNeil, Chengcheng Zhang, Stefan Zeisler , et al. · 2020

Background : ⁶⁴Cu is one of the few radioisotopes that can be used for both imaging and therapy, enabling theranostics with identical chemical composition. Development of stable chelators is essential to harness the potential of…

Ce- and B-Doped Silica Fibers for Monitoring Low-Energy Proton Beams on a Medical Cyclotron Open

Cornelia Hoehr, Matthew Hanna, Stefan Zeisler, Crystal Penner, Matthew Hughes Stokely , et al. · 2020

Many medical isotopes can be produced on a small cyclotron. The alignment and profiles of low-energy proton beams from cyclotrons used for medical radioisotope production, such as the TR13 cyclotron at TRIUMF, Canada, cannot be directly qu…

Ac-225 Production using TRIUMF’s 500 MeV Cyclotron Open

Andrew K. H. Robertson, Cornelia Hoehr, Andrew Lobbezoo, Louis Moskven, Valery Radchenko , et al. · 2019

A Compact Quick-Release Solid Target System for the TRIUMF TR13 Cyclotron Open

Stefan Zeisler, Benjamin Clarke, Joel Kumlin, B. Hook, Samuel Varah , et al. · 2019

A new solid target system for the TRIUMF TR13 cyclotron that can accommodate target discs with a 1-2-mm thickness and a 28-mm diameter has been developed. The target system design is based on a modified clamping mechanism of a KF-40 vacuum…

Fused Zinc Target for the Production of Gallium Radioisotopes Open

Stefan Zeisler, Alan Limoges, Joel Kumlin, Jonathan Siikanen, Cornelia Hoehr · 2019

Gallium-68 is a popular radioisotope for positron emission tomography. To make gallium-68 more accessible, we developed a new solid target for medical cyclotrons. Fused zinc targets promise a new, efficient, and reliable technique without …

Medical Isotope Production at TRIUMF – from Imaging to Treatment Open

Cornelia Hoehr, François Bénard, K. Buckley, Jason R. Crawford, A. Gottberg , et al. · 2017

TRIUMF has a long history of medical isotope production. For more than 40 years, the Life Sciences Division at TRIUMF has produced isotopes for Positron Emission Tomography (PET) for the local hospitals. Recently, the division has taken on…

CCDC 1459051: Experimental Crystal Structure Determination Open

Caterina F. Ramogida, Eszter Boros, Brian O. Patrick, Stefan Zeisler, Joel Kumlin , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1458998: Experimental Crystal Structure Determination Open

Caterina F. Ramogida, Eszter Boros, Brian O. Patrick, Stefan Zeisler, Joel Kumlin , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

High power targets for cyclotron production of 99mTc Open

Stefan Zeisler, V. Hanemaayer, K. Buckley, B. Hook, S. MeDiarmid , et al. · 2015

Introduction\nTechnetium-99m, supplied in the form of 99Mo/99mTc generators, is the most widely used radioisotope for nuclear medical imaging. The parent isotope 99Mo is currently produced in nuclear reactors. Recent disruptions in the 99M…

Production of radiometals in a liquid target Open

Cornelia Hoehr, E. Oehlke, Xianglin Hou, Stefan Zeisler, Mickaël Adam , et al. · 2015

Introduction \nAccess to radiometals suitable for labeling novel molecular imaging agents requires that they be routinely available and inexpensive to obtain. Proximity to a cyclotron center outfitted with solid target hardware, or to an i…

Direct Production of 99mTc via 100Mo(p,2n) on Small Medical Cyclotrons Open

Paul Schaffer, François Bénard, Aaron Bernstein, K. Buckley, A. Ćeller , et al. · 2015

From the efforts of a number of Canadian institutions and private industry collaborations, direct production of 99mTc using medical cyclotrons has recently been advanced from a 1970's academic exercise to a commercial, economically viable …

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