Stefania Patti
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View article: Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering
Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering Open
A ( S )-selective amine transaminase from a Streptomyces strain, Sbv333-ATA, is a biocatalyst showing both high thermostability with a melting temperature of 85 °C and broad substrate specificity for the amino acceptor. This enzyme was fur…
View article: Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering
Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering Open
A (S)-selective amine transaminase from a Streptomyces strain, Sbv333-ATA is a biocatalyst showing both high thermostability with a melting temperature of 85oC and broad substrate specificity for the amino acceptor. This enzyme …
View article: From the discovery of novel enzymes to their synthetic application: investigating and harnessing natural biodiversity toward efficient and selective bioprocesses
From the discovery of novel enzymes to their synthetic application: investigating and harnessing natural biodiversity toward efficient and selective bioprocesses Open
View article: Advances and Challenges in the Development of Immobilized Enzymes for Batch and Flow Biocatalyzed Processes
Advances and Challenges in the Development of Immobilized Enzymes for Batch and Flow Biocatalyzed Processes Open
The development of immobilized enzymes both for batch and continuous flow biocatalytic processes has gained significant traction in recent years, driven by the need for cost‐effective and sustainable production methods in the fine chemical…
View article: Two‐Step Biocatalytic Synthesis of (1<i>S</i>)‐Nor(pseudo)ephedrine Catalyzed by Immobilized Enzymes
Two‐Step Biocatalytic Synthesis of (1<i>S</i>)‐Nor(pseudo)ephedrine Catalyzed by Immobilized Enzymes Open
Nor(pseudo)ephedrines [N(P)Es] are naturally occurring compounds showing sympathomimetic activity that have many applications especially in the chemical industry and in the pharmaceutical field. Recently a two‐step biocatalytic cascade for…
View article: Insight into the Stereoselective Synthesis of (1<i>S</i>)‐Nor(pseudo)ephedrine Analogues by a Two‐Steps Biocatalytic Process
Insight into the Stereoselective Synthesis of (1<i>S</i>)‐Nor(pseudo)ephedrine Analogues by a Two‐Steps Biocatalytic Process Open
Nor(pseudo)ephedrines (N(P)Es), vicinal amino alcohols possessing sympathomimetic biological activity, constitute valuable intermediates and chiral building blocks for the organic synthesis of several active pharmaceutical ingredients (API…
View article: Promiscuity and Selectivity of Hydroxysteroid Dehydrogenases in the Biocatalyzed Reduction of 1,2‐Diketones
Promiscuity and Selectivity of Hydroxysteroid Dehydrogenases in the Biocatalyzed Reduction of 1,2‐Diketones Open
Hydroxysteroid dehydrogenases (HSDHs) are NAD(P)H‐dependent alcohol dehydrogenases (ADHs) known for their exceptional stereo‐ and regioselectivity when acting on natural substrates, including neutral steroids, bile acids, and various stero…