Stefania Serra
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View article: In vitro evaluation of the carcinogenic potential of perfluorinated chemicals
In vitro evaluation of the carcinogenic potential of perfluorinated chemicals Open
Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are the major components of long-chain per- and polyfluorinated alkyl substances (PFAS), known for their chemical stability and environmental persistence. Even if PFOA and …
View article: The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens
The Cell Transformation Assay: A Historical Assessment of Current Knowledge of Applications in an Integrated Approach to Testing and Assessment for Non-Genotoxic Carcinogens Open
The history of the development of the cell transformation assays (CTAs) is described, providing an overview of in vitro cell transformation from its origin to the new transcriptomic-based CTAs. Application of this knowledge is utilized to …
View article: Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation
Mechanistic Interrogation of Cell Transformation In Vitro: The Transformics Assay as an Exemplar of Oncotransformation Open
The Transformics Assay is an in vitro test which combines the BALB/c 3T3 Cell Transformation Assay (CTA) with microarray transcriptomics. It has been shown to improve upon the mechanistic understanding of the CTA, helping to identify mecha…
View article: Comprehensive Evaluation Report
Comprehensive Evaluation Report Open
Deliverable D4.5 provides a description and evaluation of the findings on the impact of citizen science in the case study sites. The MICS impact assessment approach was applied to the five MICS case study sites across Europe, each of which…
View article: Mechanistic Interrogation of Cell Transformation in Vitro: The Transformics Assay as an Exemplar of Oncotransformation
Mechanistic Interrogation of Cell Transformation in Vitro: The Transformics Assay as an Exemplar of Oncotransformation Open
The rodent-based life-time cancer bioassay is still the basic experimental paradigm to assess the carcinogenic potential of chemicals, with relatively little progress regarding the acceptance of in vitro tests. The Transformics Assay is an…
View article: Report on pilot testing in the Southern Europe region (IT)
Report on pilot testing in the Southern Europe region (IT) Open
This deliverable provides a description of the site and set up of citizen science activities in the Italian case study where the MICS impact assessment will be applied. The Italian case study focuses on the Marzenego River and its tributar…
View article: The Secretive Liaison of Particulate Matter and SARS-CoV-2. A Hypothesis and Theory Investigation
The Secretive Liaison of Particulate Matter and SARS-CoV-2. A Hypothesis and Theory Investigation Open
As the novel coronavirus disease sweeps across the world, there is growing speculation on the role that atmospheric factors may have played on the different distribution of SARS-CoV-2, and on the epidemiological characteristics of COVID-19…
View article: Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model
Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model Open
The use of in vitro alternative methods is a promising approach to characterize the hazardous properties of environmental chemical mixtures, including urban airborne particulate matter (PM). The aim of this study was to examine seasonal di…
View article: Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model_suppl
Hazard assessment of air pollutants: The transforming ability of complex pollutant mixtures in the Bhas 42 cell model_suppl Open
The use of in vitro alternative methods is a promising approach to characterize the hazardous properties of environmental chemical mixtures, including urban airborne particulate matter (PM). The aim of this study was to examine seasonal di…
View article: Air Pollution and Human Health Risk: Evaluation of Carcinogenic Potential of Urban Airborne Particulate Matter
Air Pollution and Human Health Risk: Evaluation of Carcinogenic Potential of Urban Airborne Particulate Matter Open
Urban airborne particulate matter (PM) is known to increase morbidity and mortality due to cardiopulmonary diseases related to inflammatory processes and genotoxic effects.
\nThe aim of this thesis is to highlight the toxic and carcinogen…