Stefanie Giera
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View article: GPR17 modulates oligodendrocyte precursor cell maturation during development but has limited impact on myelin regeneration following demyelinating insults
GPR17 modulates oligodendrocyte precursor cell maturation during development but has limited impact on myelin regeneration following demyelinating insults Open
Pharmacological enhancement of myelin regeneration is broadly recognized as the next frontier in therapeutic approaches for demyelinating diseases of the CNS such as multiple sclerosis. However, although several molecular targets for remye…
View article: Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development
Spatiotemporal profiling of adhesion G protein-coupled receptors in developing mouse and human pancreas reveals a role for GPR56 in islet development Open
Introduction G protein-coupled receptors (GPCRs) are cell-surface proteins that are targeted therapeutically for a range of disorders, including diabetes. Adhesion GPCRs (aGPCRs) are the second largest class of the GPCR superfamily and som…
View article: Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds
Artificial axons as a biomimetic 3D myelination platform for the discovery and validation of promyelinating compounds Open
View article: Artificial axons - a biomimetic 3D myelination platform for the discovery and validation of pro-myelinating compounds
Artificial axons - a biomimetic 3D myelination platform for the discovery and validation of pro-myelinating compounds Open
Multiple sclerosis (MS), a chronic neurodegenerative disease driven by damage to the protective myelin sheath, is currently incurable. Today, all clinically available treatments modulate the immune-mediated symptoms of the disease but they…
View article: High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells
High-throughput screening for myelination promoting compounds using human stem cell-derived oligodendrocyte progenitor cells Open
Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for CNS demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelination-promoting compo…
View article: High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets
High-Throughput Screening for Myelination Promoting Compounds Using Human Stem Cell-derived Oligodendrocyte Progenitor Cells Identifies Novel Targets Open
Promoting myelination capacity of endogenous oligodendrocyte precursor cells (OPCs) is a promising therapeutic approach for central nervous system demyelinating disorders such as Multiple Sclerosis (MS). To aid in the discovery of myelinat…
View article: Individual Polychlorinated Biphenyl (PCB) Congeners Interact to Disrupt Thyroid Hormone Action During Development
Individual Polychlorinated Biphenyl (PCB) Congeners Interact to Disrupt Thyroid Hormone Action During Development Open
Nearly 20% of U.S. children are reported to have neurobehavioral deficits in part linked to environmental exposure to industrial chemicals like polychlorinated biphenyls (PCBs). PCB exposure is associated with neurotoxicity including both …
View article: A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding Open
View article: A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding
A splicing isoform of GPR56 mediates microglial synaptic refinement via phosphatidylserine binding Open
Developmental synaptic remodeling is important for the formation of precise neural circuitry and its disruption has been linked to neurodevelopmental disorders such as autism and schizophrenia. Microglia prune synapses, but integration of …
View article: GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist
GAIN domain–mediated cleavage is required for activation of G protein–coupled receptor 56 (GPR56) by its natural ligands and a small-molecule agonist Open
Adhesion G protein-coupled receptors (aGPCRs) represent a distinct family of GPCRs that regulate several developmental and physiological processes. Most aGPCRs undergo GPCR autoproteolysis-inducing domain-mediated protein cleavage, which p…
View article: Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG
Re-programing Chromatin with a Bifunctional LSD1/HDAC Inhibitor Induces Therapeutic Differentiation in DIPG Open
View article: Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes Open
View article: Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain
Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain Open
Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. In this study, we analyzed the RNA expression p…
View article: The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function
The adhesion receptor GPR56 is activated by extracellular matrix collagen III to improve β-cell function Open
We have demonstrated that collagen III improves islet function by increasing insulin secretion and protecting against apoptosis. Our data suggest that collagen III may be effective in optimising islet function to improve islet transplantat…
View article: Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells
Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells Open
In the central nervous system (CNS), myelin formation and repair are regulated by oligodendrocyte (OL) lineage cells, which sense and integrate signals from their environment, including from other glial cells and the extracellular matrix (…
View article: Author response: Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells
Author response: Microglial transglutaminase-2 drives myelination and myelin repair via GPR56/ADGRG1 in oligodendrocyte precursor cells Open
Article Figures and data Abstract Introduction Results Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract In the central nervous system (CNS), myelin formation…
View article: Dual deletion of <i>Itga3</i> and <i>Gpr56</i> results in cortical lamination defect.
Dual deletion of <i>Itga3</i> and <i>Gpr56</i> results in cortical lamination defect. Open
(A–D) Nissl staining on coronal sections of P0 Itga3+/−/Gpr56+/− (A), Itga3−/−/Gpr56+/− (B), Itga3+/−/Gpr56−/− (C), and Itga3−/−/Gpr56
View article: The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211
The Adhesion GPCR GPR126 Has Distinct, Domain-Dependent Functions in Schwann Cell Development Mediated by Interaction with Laminin-211 Open
View article: The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development
The adhesion G protein-coupled receptor GPR56 is a cell-autonomous regulator of oligodendrocyte development Open