Stefanie Lawrinowitz
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View article: Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms
Machine Learning Uncovers Natural Product Modulators of the 5-Lipoxygenase Pathway and Facilitates the Elucidation of Their Biological Mechanisms Open
Machine learning (ML) models have made inroads into chemical sciences, with optimization of chemical reactions and prediction of biologically active molecules being prime examples thereof. These models excel where physical experiments are …
View article: Bifurcate evolution of quinone synthetases in basidiomycetes
Bifurcate evolution of quinone synthetases in basidiomycetes Open
Background The terphenylquinones represent an ecologically remarkable class of basidiomycete natural products as they serve as central precursors of pigments and compounds that impact on microbial consortia by modulating bacterial biofilms…
View article: Blue Light-Dependent Pre-mRNA Splicing Controls Pigment Biosynthesis in the Mushroom <i>Terana caerulea</i>
Blue Light-Dependent Pre-mRNA Splicing Controls Pigment Biosynthesis in the Mushroom <i>Terana caerulea</i> Open
The regulation of natural product biosyntheses in mushrooms in response to environmental cues is poorly understood. We addressed this knowledge gap and chose the cobalt crust mushroom Terana caerulea as our model.
View article: Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination
Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination Open
Electronic energies, entropies, enthalpies, Gibbs free energies, and lowest frequencies of the calculated structures (Energies.xlsx). Fitting of kinetic data (Figure_5ci.opju). Gaussian 16 output files for all calculated structures (Gaussi…
View article: Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination
Controlled masking and targeted release of redox-cycling ortho-quinones via a C–C bond-cleaving 1,6-elimination Open
Electronic energies, entropies, enthalpies, Gibbs free energies, and lowest frequencies of the calculated structures (Energies.xlsx). Fitting of kinetic data (Figure_5ci.opju). Gaussian 16 output files for all calculated structures (Gaussi…