Stefanie Pektor
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View article: Genetic Code Expansion for Site-Specific Labeling of Antibodies with Radioisotopes
Genetic Code Expansion for Site-Specific Labeling of Antibodies with Radioisotopes Open
Due to their target specificity, antibody-drug conjugates─monoclonal antibodies conjugated to a cytotoxic moiety─are efficient therapeutics that can kill malignant cells overexpressing a target gene. Linking an antibody with radioisotopes …
View article: Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach
Hybrid Chelator-Based PSMA Radiopharmaceuticals: Translational Approach Open
(1) Background: Prostate-specific membrane antigen (PSMA) has been extensively studied in the last decade. It became a promising biological target in the diagnosis and therapy of PSMA-expressing cancer diseases. Although there are several …
View article: Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA
Iodine-124 PET quantification of organ-specific delivery and expression of NIS-encoding RNA Open
View article: Targeting of Immune Cells with Trimannosylated Liposomes
Targeting of Immune Cells with Trimannosylated Liposomes Open
Dendritic cells (DCs) are a compelling target in cancer immunotherapy as they initialize strong antigen‐specific immune responses. Drug delivery systems (DDSs) such as liposomes provide the opportunity to deliver antigens and immunostimula…
View article: PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients with Biochemical Recurrent Prostate Cancer
PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients with Biochemical Recurrent Prostate Cancer Open
68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC) in European clinical practice. The goal of this study is to determine the optimum time for performing thes…
View article: Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy
Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy Open
View article: Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging
Evaluation of the inverse electron demand Diels-Alder reaction in rats using a scandium-44-labelled tetrazine for pretargeted PET imaging Open
View article: <sup>68</sup>Ga[Ga]-, <sup>111</sup>In[In]-oxine: a novel strategy of <i>in situ</i> radiolabeling of HPMA-based micelles.
<sup>68</sup>Ga[Ga]-, <sup>111</sup>In[In]-oxine: a novel strategy of <i>in situ</i> radiolabeling of HPMA-based micelles. Open
Polymeric micelles are of increasing interest as drug delivery vehicles since they can accumulate in tumor tissue through EPR effect and deliver their hydrophobic cargo. The pharmacology can be visualized and quantified noninvasively by mo…
View article: Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer
Evaluation of a novel monoclonal antibody against tumor-associated MUC1 for diagnosis and prognosis of breast cancer Open
There is still a great unmet medical need concerning diagnosis and treatment of breast cancer which could be addressed by utilizing specific molecular targets. Tumor-associated MUC1 is expressed on over 90 % of all breast cancer entities a…
View article: Evaluation of Radiolabeled Girentuximab In Vitro and In Vivo
Evaluation of Radiolabeled Girentuximab In Vitro and In Vivo Open
Girentuximab (cG250) targets carbonic anhydrase IX (CAIX), a protein which is expressed on the surface of most renal cancer cells (RCCs). cG250 labeled with 177Lu has been used in clinical trials for radioimmunotherapy (RIT) of RCCs. In th…
View article: In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET
In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET Open
View article: Comparison Study of Two Differently Clicked 18F-Folates—Lipophilicity Plays a Key Role
Comparison Study of Two Differently Clicked 18F-Folates—Lipophilicity Plays a Key Role Open
Within the last decade, several folate-based radiopharmaceuticals for Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) have been evaluated; however, there is still a lack of suitable 18F-folates for…
View article: Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging
Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging Open
View article: Additional file 1: of Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging
Additional file 1: of Labeling of DOTA-conjugated HPMA-based polymers with trivalent metallic radionuclides for molecular imaging Open
Supporting information. (ZIP 77Â kb)
View article: The nanovaccine DEX(OVA+LPS) induces profound activation of antigen-specific CD8<sup>+</sup> T cells <i>in vivo.</i>
The nanovaccine DEX(OVA+LPS) induces profound activation of antigen-specific CD8<sup>+</sup> T cells <i>in vivo.</i> Open
C57BL/6 mice received CFSE-labeled, OVA-specific OT-I T cells (107) i.v. Two days later, groups of mice (each five animals) were either left untreated or were immunized with OVA (4 µg per mouse), LPS (4 µg), and DEX parti…