Stefanie Schreiber
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View article: Vascular and Neural Transcriptomics Reveal Stage‐Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension
Vascular and Neural Transcriptomics Reveal Stage‐Dependent Pathways to Inflammation and Cognitive Dysfunction in a Rat Model of Hypertension Open
Background Chronic arterial hypertension causes cerebral microvascular dysfunction and increases dementia risk in aging. However, cognitive health preservation by therapeutic blood pressure lowering alone is limited and depends on disease …
View article: Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention
Acute exercise alters immune responses in older adults, with extracellular vesicle changes observed in a high-intensity intervention Open
Introduction Aging is accompanied by immunoscenescence and chronic low-grade inflammation (inflammaging), contributing to age-related diseases. Physical exercise is a potent modulator of immune function and systemic inflammation, yet the e…
View article: DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation
DRIPS: Domain Randomisation for Image-based Perivascular spaces Segmentation Open
Perivascular spaces (PVS) are emerging as sensitive imaging markers of brain health. Yet, accurate out-of-sample PVS segmentation remains challenging since existing methods are modality-specific, require dataset-specific tuning, or rely on…
View article: Corticosteroid Treatment and Hemorrhage Risk in Cerebral Amyloid Angiopathy with Cortical Superficial Siderosis: A Matched Cohort Analysis
Corticosteroid Treatment and Hemorrhage Risk in Cerebral Amyloid Angiopathy with Cortical Superficial Siderosis: A Matched Cohort Analysis Open
Cortical superficial siderosis (cSS) is the strongest marker of future intracranial hemorrhage (ICH) in cerebral amyloid angiopathy (CAA), a condition without disease-modifying therapy. Emerging evidence suggests that cSS may reflect menin…
View article: Meningovascular inflammation in cerebral amyloid angiopathy-related cortical superficial siderosis
Meningovascular inflammation in cerebral amyloid angiopathy-related cortical superficial siderosis Open
The role of inflammation in cortical superficial siderosis (cSS), a marker of cerebral amyloid angiopathy (CAA) linked to high hemorrhage risk, is unclear. We examined 14 patients with cSS using 3T post-contrast vessel wall MRI (VWI) and C…
View article: Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis
Association between the Edinburgh CT and genetic diagnostic criteria for cerebral amyloid angiopathy-associated lobar intracerebral haemorrhage and recurrent intracerebral haemorrhage: an individual patient data meta-analysis Open
UK Medical Research Council, The Stroke Association, The Wellcome Trust, and The British Heart Foundation.
View article: Arterial stiffness and vascular aging: mechanisms, prevention, and therapy
Arterial stiffness and vascular aging: mechanisms, prevention, and therapy Open
View article: Putamen vascularization on high-resolution 7T MRI is associated with perfusion and cognitive performance in cerebral small vessel disease
Putamen vascularization on high-resolution 7T MRI is associated with perfusion and cognitive performance in cerebral small vessel disease Open
This study demonstrates the impact of an impaired arterial network in the putamen on blood supply and cognitive function across the continuum of CSVD.
View article: Assessing Arterial Patterns in the Motor Cortex With 7 Tesla Magnetic Resonance Imaging and Vessel Distance Mapping
Assessing Arterial Patterns in the Motor Cortex With 7 Tesla Magnetic Resonance Imaging and Vessel Distance Mapping Open
Leveraging high‐resolution 7 T magnetic resonance imaging (MRI) and vessel distance mapping (VDM), the arterial supply patterns and dominances of the motor cortex, which could previously only be studied postmortem, were assessed in vivo an…
View article: Diagnosis and management of cerebral amyloid angiopathy: a scientific statement from the International CAA Association and the World Stroke Organization
Diagnosis and management of cerebral amyloid angiopathy: a scientific statement from the International CAA Association and the World Stroke Organization Open
Cerebral amyloid angiopathy (CAA) is a well-recognized and challenging disease for neurologists and other clinicians caring for the rapidly aging worldwide population. CAA is a major cause of spontaneous lobar intracerebral hemorrhage (ICH…
View article: Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage
Cerebrospinal Fluid Aβ Biomarkers Predict Recurrent Hemorrhage and Identify Cerebral Amyloid Angiopathy in Patients With Lobar Hemorrhage Open
Background Recurrent hemorrhage represents a significant risk for patients with lobar hemorrhage and underlying cerebral amyloid angiopathy. However, it remains unknown, whether cerebrospinal fluid biomarkers of β‐amyloid (Aβ) retention, p…
View article: CD19xCD3 T cell engager blinatumomab effective in refractory generalized myasthenic syndromes
CD19xCD3 T cell engager blinatumomab effective in refractory generalized myasthenic syndromes Open
In this case series, we report the first off-label use of the CD19xCD3 T cell engager blinatumomab in two patients with generalized myasthenia gravis (MG). Refractory MG remains a major therapeutic challenge, with patients experiencing sev…
View article: Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance
Linking latent trajectories of ageing-related atrophy, white matter hyperintensities, and cognitive ageing over four years: Insights into brain maintenance Open
Introduction We studied brain maintenance, examining the co-evolution of ageing-related atrophy, white matter hyperintensities (WMH), and cognition, alongside domain-specific and domain-general contributions of lifestyle and personality. M…
View article: The impact of a 6-month structured dance training program on resting blood pressure and resting heart rate in MCI patients
The impact of a 6-month structured dance training program on resting blood pressure and resting heart rate in MCI patients Open
Background Arterial hypertension is a major risk factor for neurodegenerative diseases. Mild cognitive impairment (MCI) is associated with a high conversion rate to clinically manifest dementia, characterized by impaired daily functioning.…
View article: Risk factors and clinical significance of neurodegenerative co-pathologies in symptomatic cerebral small vessel disease
Risk factors and clinical significance of neurodegenerative co-pathologies in symptomatic cerebral small vessel disease Open
Background Cerebral small vessel disease (CSVD) often coexists with neurodegenerative pathologies, yet their role remains underexplored. This study aims to determine their prevalence, risk factors, and cognitive effects in patients with de…
View article: Association of body mass index and clinical response in patients receiving ofatumumab for treatment of multiple sclerosis
Association of body mass index and clinical response in patients receiving ofatumumab for treatment of multiple sclerosis Open
Background The impact of body weight on disability progression rates among patients receiving ofatumumab was not evaluated yet. Methods Among patients from a multicentre prospective cohort, baseline demographics were compared among body ma…
View article: Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events
Heteroresistance in Enterobacter cloacae complex caused by variation in transient gene amplification events Open
View article: Perivascular spaces in neuropsychiatric post-COVID syndrome
Perivascular spaces in neuropsychiatric post-COVID syndrome Open
Neuropsychiatric symptoms, such as executive dysfunction, fatigue, and depression, are common and disabling in post-COVID syndrome, often hindering daily activities and work. While the exact mechanisms remain unclear, recent studies sugges…
View article: Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms
Associations of inferior frontal sulcal hyperintensities on brain MRI with cerebral small vessel disease, cognitive function, and depression symptoms Open
View article: LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro
LFA-1: A potential key player in microglia-mediated neuroprotection against oxygen-glucose deprivation in vitro Open
For the last 38 years, all neuroprotective agents for patients with ischemic stroke have failed in clinical trials. The innate immune system, particularly microglia, is a much-discussed target for neuroprotective agents. Promising results …
View article: <i>MedShapeNet</i> – a large-scale dataset of 3D medical shapes for computer vision
<i>MedShapeNet</i> – a large-scale dataset of 3D medical shapes for computer vision Open
Objectives The shape is commonly used to describe the objects. State-of-the-art algorithms in medical imaging are predominantly diverging from computer vision, where voxel grids, meshes, point clouds, and implicit surface models are used. …
View article: Pericytes and Extracellular Vesicle Interactions in Neurovascular Adaptation to Chronic Arterial Hypertension
Pericytes and Extracellular Vesicle Interactions in Neurovascular Adaptation to Chronic Arterial Hypertension Open
Background Chronic arterial hypertension restructures the vascular architecture of the brain, leading to a series of pathological responses that culminate in cerebral small‐vessel disease. Pericytes respond dynamically to vascular challeng…
View article: The impact of a smartphone‐assisted real‐world wayfinding training on spatial memory performance as measured in VR in older adults
The impact of a smartphone‐assisted real‐world wayfinding training on spatial memory performance as measured in VR in older adults Open
Background Non‐pharmacological interventions that improve cognitive functioning in patients with Alzheimer’s disease will play a crucial role in the coming years to support their independence in daily living. Here, we investigated the pote…
View article: Contrast‐agnostic deep‐learning‐based detection of perivascular spaces in magnetic resonance imaging
Contrast‐agnostic deep‐learning‐based detection of perivascular spaces in magnetic resonance imaging Open
Background To date, all computerised perivascular spaces (PVS) quantification methods require case‐wise, imaging modality, or study‐specific parameter adjustments, and suffer from generalisability problems in clinical settings, and misdete…
View article: Cortical neurodegeneration influences annual posterior white matter hyperintensity progression
Cortical neurodegeneration influences annual posterior white matter hyperintensity progression Open
Background For over three decades, the concomitance of cortical neurodegeneration and white matter hyperintensities (WMH) has sparked discussion about their coupled temporal dynamics (Garnier‐Crussard et al. 2023). Longitudinal evidence su…
View article: Perivascular space enlargement and cerebrovascular and Alzheimer’s diseases
Perivascular space enlargement and cerebrovascular and Alzheimer’s diseases Open
Background Perivascular spaces (PVS) can become large enough to be visible in magnetic resonance imaging (MRI). The exact aetiology of PVS enlargement in humans remains, however, elusive and under continuous debate [1‐5]. Here, we tracked …
View article: Physical Activity and Neurodegenerative Diseases: Potential Role in Prevention and Therapy
Physical Activity and Neurodegenerative Diseases: Potential Role in Prevention and Therapy Open
Physical activity and exercise are low-cost interventions in primary and secondary prevention of several noncommunicable disease (e.g. cardiovascular diseases, chronic kidney disease, neurodegenerative and neurovascular disease). In the co…
View article: SMILE-UHURA Challenge -- Small Vessel Segmentation at Mesoscopic Scale from Ultra-High Resolution 7T Magnetic Resonance Angiograms
SMILE-UHURA Challenge -- Small Vessel Segmentation at Mesoscopic Scale from Ultra-High Resolution 7T Magnetic Resonance Angiograms Open
The human brain receives nutrients and oxygen through an intricate network of blood vessels. Pathology affecting small vessels, at the mesoscopic scale, represents a critical vulnerability within the cerebral blood supply and can lead to s…
View article: Immune system activation and cognitive impairment in arterial hypertension
Immune system activation and cognitive impairment in arterial hypertension Open
Chronic arterial hypertension disrupts the integrity of the cerebral microvasculature, doubling the risk of age-related dementia. Despite sufficient antihypertensive therapy in still a significant proportion of individuals blood pressure l…
View article: Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study
Perivascular space enlargement accelerates in ageing and Alzheimer’s disease pathology: evidence from a three-year longitudinal multicentre study Open
Background Perivascular space (PVS) enlargement in ageing and Alzheimer’s disease (AD) and the drivers of such a structural change in humans require longitudinal investigation. Elucidating the effects of demographic factors, hypertension, …