Stefanie Wissmann
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View article: Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay
Neutrophil trapping and nexocytosis, mast cell-mediated processes for inflammatory signal relay Open
Neutrophils are sentinel immune cells with essential roles for antimicrobial defense. Most of our knowledge on neutrophil tissue navigation derived from wounding and infection models, whereas allergic conditions remained largely neglected.…
View article: B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice
B cell–intrinsic requirement for WNK1 kinase in antibody responses in mice Open
Migration and adhesion play critical roles in B cells, regulating recirculation between lymphoid organs, migration within lymphoid tissue, and interaction with CD4+ T cells. However, there is limited knowledge of how B cells integrate chem…
View article: DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration
DOCK2 and phosphoinositide-3 kinase δ mediate two complementary signaling pathways for CXCR5-dependent B cell migration Open
Naive B cells use the chemokine receptor CXCR5 to enter B cell follicles, where they scan CXCL13-expressing ICAM-1 + VCAM-1 + follicular dendritic cells (FDCs) for the presence of antigen. CXCL13-CXCR5-mediated motility is mainly driven by…
View article: Ibrutinib Does Not Impact CCR7-Mediated Homeostatic Migration in T-Cells from Chronic Lymphocytic Leukemia Patients
Ibrutinib Does Not Impact CCR7-Mediated Homeostatic Migration in T-Cells from Chronic Lymphocytic Leukemia Patients Open
Bruton’s tyrosine kinase inhibitor ibrutinib has significantly changed treatment landscape in chronic lymphocytic leukemia (CLL). Growing evidence supports ibrutinib to work beyond the effect on tumor cells by means of, for example, restor…
View article: The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis
The Tec Kinase Itk Integrates Naïve T Cell Migration and In Vivo Homeostasis Open
Naïve T cells (T N ) constitutively recirculate through secondary lymphatic organs (SLOs), where they scan dendritic cells (DCs) for cognate peptide-loaded major histocompatibility complexes (pMHC). Continuous trafficking between SLOs not …
View article: B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses
B cell-intrinsic requirement for WNK1 kinase in T cell-dependent antibody responses Open
Migration and adhesion play critical roles in B cells, regulating recirculation between lymphoid organs, migration within lymphoid tissue and interaction with CD4 + T cells. However, there is limited knowledge of how B cells integrate chem…
View article: Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8+ T Cells
Organ-Specific Surveillance and Long-Term Residency Strategies Adapted by Tissue-Resident Memory CD8+ T Cells Open
Tissue-resident CD8 + T cells (CD8 + T RM ) populate lymphoid and non-lymphoid tissues after infections as first line of defense against re-emerging pathogens. To achieve host protection, CD8 + T RM have developed surveillance strategies t…