Stefano Freddi
YOU?
Author Swipe
View article: TBC1D22B Regulates ER‐to‐Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer
TBC1D22B Regulates ER‐to‐Golgi Trafficking via RAB1B Inactivation and Promotes Oncogenic Programs in Breast Cancer Open
TBC1D22B is a GTPase‐activating protein (GAP) associated with poor prognosis in breast cancer (BC). Using complementary proximity‐labeling and co‐immunoprecipitation proteomics, the TBC1D22B interactome in BC cells is defined, revealing st…
View article: Endocytic control of cell-autonomous and non-cell-autonomous functions of p53
Endocytic control of cell-autonomous and non-cell-autonomous functions of p53 Open
NUMB is an endocytic protein with tumor suppressor activity, largely mediated by its ability to inhibit p53 degradation. This function depends on the inclusion of a short alternatively spliced exon (Ex3) in NUMB, although the mechanistic l…
View article: The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels
The CRL7 <sup>FBXW8</sup> Complex Controls the Mammary Stem Cell Compartment through Regulation of NUMB Levels Open
NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto‐oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss of function (LOF), mediated by …
View article: A <i>TranSNP</i> in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells
A <i>TranSNP</i> in the DDIT4 mRNA can impact its translation efficiency and modulate p53-dependent responses in cancer cells Open
Relatively few studies have examined the link between SNPs and mRNA translation, despite the established importance of translational regulation in shaping cell phenotypes. We developed a pipeline analyzing the allelic imbalance in total an…
View article: The CRL7<sup>FBXW8</sup>Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels
The CRL7<sup>FBXW8</sup>Complex Controls the Mammary Stem Cell Compartment Through Regulation of NUMB Levels Open
NUMB is a tumor suppressor gene that functions by inhibiting the action of the NOTCH proto-oncogene and enhancing the levels and activity of the tumor suppressor protein p53. In breast cancer (BC), NUMB loss-of-function (LOF), mediated by …
View article: Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis
Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis Open
View article: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling Open
View article: TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype
TBC1 domain-containing proteins are frequently involved in triple-negative breast cancers in connection with the induction of a glycolytic phenotype Open
View article: Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry
Loss of the tumor suppressor NUMB drives aggressive bladder cancer through hyperactivation of a RhoA/ROCK/YAP signaling circuitry Open
Bladder cancer (BCa) is one of the most challenging and costly cancers to treat, yet little progress has been made on the development of predictive biomarkers and targeted therapies. Here, we uncover a critical function of Numb as a tumor …
View article: A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism
A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism Open
View article: A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism
A tripartite organelle platform links growth factor receptor signaling to mitochondrial metabolism Open
One open question in the biology of growth factor receptors is how a quantitative input ( i.e., ligand concentration) is decoded by the cell to produce specific response(s). Here, we show that an EGFR endocytic mechanism, non-clathrin endo…
View article: p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response
p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response Open
The p140Cap adaptor protein is a tumor suppressor in breast cancer associated with a favorable prognosis. Here we highlight a function of p140Cap in orchestrating local and systemic tumor-extrinsic events that eventually result in inhibiti…
View article: Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool
Aberrant phosphorylation inactivates Numb in breast cancer causing expansion of the stem cell pool Open
Asymmetric cell division is a key tumor suppressor mechanism that prevents the uncontrolled expansion of the stem cell (SC) compartment by generating daughter cells with alternative fates: one retains SC identity and enters quiescence and …
View article: CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer
CDK12 promotes tumorigenesis but induces vulnerability to therapies inhibiting folate one-carbon metabolism in breast cancer Open
View article: Comparison of StemPrintER with Oncotype DX Recurrence Score for predicting risk of breast cancer distant recurrence after endocrine therapy
Comparison of StemPrintER with Oncotype DX Recurrence Score for predicting risk of breast cancer distant recurrence after endocrine therapy Open
View article: L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling
L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling Open
View article: miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer
miR-146 connects stem cell identity with metabolism and pharmacological resistance in breast cancer Open
Although ectopic overexpression of miRNAs can influence mammary normal and cancer stem cells (SCs/CSCs), their physiological relevance remains uncertain. Here, we show that miR-146 is relevant for SC/CSC activity. MiR-146a/b expression is …
View article: Additional file 2 of L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling
Additional file 2 of L1CAM promotes ovarian cancer stemness and tumor initiation via FGFR1/SRC/STAT3 signaling Open
Additional file 2.
View article: Unconventional endocytosis and trafficking of transferrin receptor induced by iron
Unconventional endocytosis and trafficking of transferrin receptor induced by iron Open
An unconventional endocytic regulatory process that directs TfR1 to lysosomal degradation in response to iron is reported. This mechanism may represent a novel posttranslational control to prevent iron overload.
View article: A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior
A self-sustaining endocytic-based loop promotes breast cancer plasticity leading to aggressiveness and pro-metastatic behavior Open
The subversion of endocytic routes leads to malignant transformation and has been implicated in human cancers. However, there is scarce evidence for genetic alterations of endocytic proteins as causative in high incidence human cancers. He…
View article: Abstract 3678: Ovarian cancer stemness is driven by a novel L1/Stat3/Src axis
Abstract 3678: Ovarian cancer stemness is driven by a novel L1/Stat3/Src axis Open
IntroductionOvarian cancer (OC) is the most lethal gynaecological malignancy due to the lack of peculiar symptoms in its early phase (Bowtell, 2010). OC often relapses as a chemoresistant disease within 3 years after surgical debulking (Le…
View article: Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling
Molecularly Distinct Clathrin-Coated Pits Differentially Impact EGFR Fate and Signaling Open
View article: A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing Open
The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing factor NOVA2, which b…
View article: Author response: A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing
Author response: A novel L1CAM isoform with angiogenic activity generated by NOVA2-mediated alternative splicing Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract The biological players involv…
View article: PO-287 A novel L1/STAT3 crosstalk drives ovarian cancer stem cell function
PO-287 A novel L1/STAT3 crosstalk drives ovarian cancer stem cell function Open
Introduction Ovarian cancer (OC) is the most lethal gynaecological malignancy due to the lack of peculiar symptoms during its onset. Moreover, OC often relapses as a chemoresistant disease within 1–2 years after surgical debulking. These p…
View article: CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells
CD73 Regulates Stemness and Epithelial-Mesenchymal Transition in Ovarian Cancer-Initiating Cells Open